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Database: UniProt/SWISS-PROT
Entry: SET2_DEBHA
LinkDB: SET2_DEBHA
Original site: SET2_DEBHA 
ID   SET2_DEBHA              Reviewed;         731 AA.
AC   Q6BM04;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   23-MAY-2018, entry version 101.
DE   RecName: Full=Histone-lysine N-methyltransferase, H3 lysine-36 specific;
DE            EC=2.1.1.43;
DE   AltName: Full=SET domain-containing protein 2;
GN   Name=SET2; OrderedLocusNames=DEHA2F09350g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC
OS   0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
RA   Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
RA   Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
RA   Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
RA   Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
RA   Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
RA   Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
RA   Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
RA   Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
RA   Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
RA   Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
RA   Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
RA   Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
RA   Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Histone methyltransferase that methylates histone H3 to
CC       form H3K36me. Involved in transcription elongation as well as in
CC       transcription repression (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000255|PROSITE-ProRule:PRU00901}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome
CC       {ECO:0000250}.
CC   -!- DOMAIN: The AWS and SET domains are necessary for transcription
CC       repression. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. SET2 subfamily. {ECO:0000255|PROSITE-ProRule:PRU00901}.
DR   EMBL; CR382138; CAG89108.2; -; Genomic_DNA.
DR   RefSeq; XP_460767.2; XM_460767.1.
DR   SMR; Q6BM04; -.
DR   PRIDE; Q6BM04; -.
DR   EnsemblFungi; CAG89108; CAG89108; DEHA2F09350g.
DR   GeneID; 2903609; -.
DR   KEGG; dha:DEHA2F09350g; -.
DR   HOGENOM; HOG000248214; -.
DR   InParanoid; Q6BM04; -.
DR   KO; K11423; -.
DR   OMA; CYVDKWV; -.
DR   OrthoDB; EOG092C3T9B; -.
DR   Proteomes; UP000000599; Chromosome F.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IEA:EnsemblFungi.
DR   GO; GO:0030437; P:ascospore formation; IEA:EnsemblFungi.
DR   GO; GO:0006354; P:DNA-templated transcription, elongation; IEA:EnsemblFungi.
DR   GO; GO:0006353; P:DNA-templated transcription, termination; IEA:EnsemblFungi.
DR   GO; GO:0016575; P:histone deacetylation; IEA:EnsemblFungi.
DR   GO; GO:0060195; P:negative regulation of antisense RNA transcription; IEA:EnsemblFungi.
DR   GO; GO:0071441; P:negative regulation of histone H3-K14 acetylation; IEA:EnsemblFungi.
DR   GO; GO:2000616; P:negative regulation of histone H3-K9 acetylation; IEA:EnsemblFungi.
DR   GO; GO:0045128; P:negative regulation of reciprocal meiotic recombination; IEA:EnsemblFungi.
DR   GO; GO:0035066; P:positive regulation of histone acetylation; IEA:EnsemblFungi.
DR   GO; GO:0030174; P:regulation of DNA-dependent DNA replication initiation; IEA:EnsemblFungi.
DR   GO; GO:1900049; P:regulation of histone exchange; IEA:EnsemblFungi.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 1.10.1740.100; -; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR025788; Hist-Lys_N-MeTrfase_SET2_fun.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR038190; SRI_sf.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF47676; SSF47676; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS51568; SAM_MT43_SET2_1; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   3: Inferred from homology;
KW   Chromosome; Coiled coil; Complete proteome; Methyltransferase;
KW   Nucleus; Reference proteome; Repressor; S-adenosyl-L-methionine;
KW   Transcription; Transcription regulation; Transferase.
FT   CHAIN         1    731       Histone-lysine N-methyltransferase, H3
FT                                lysine-36 specific.
FT                                /FTId=PRO_0000269787.
FT   DOMAIN       52    108       AWS. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00562}.
FT   DOMAIN      110    227       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   DOMAIN      234    250       Post-SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00155}.
FT   DOMAIN      477    511       WW. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00224}.
FT   COILED      539    618       {ECO:0000255}.
SQ   SEQUENCE   731 AA;  84410 MW;  05C22BD4D8ACD30C CRC64;
     MSDMEELDVK AKQYTPQLFL ESEDKTDEAR STFNELQECT YSSKSTGSSG QHEHMTCDCY
     EDWDSDKQQN MACGEDSDCI NRVTSVECSN KFCTCGNDCQ NQRFQKKQYA NVTVIQTELK
     GYGLRANEDI SESSFIYEYI GEVIDEESFR KRMIDYDTKK LIHFYFMMLK KDSFIDATMK
     GSLARFCNHS CNPNAYVDKW VVGEKLRMGI FSKRNIQKGE EITFDYNVDR YGAQSQPCYC
     GEPNCIKWMG GKTQTDAALL LPDGISEALG VTHKQERQWL KENKHLRSKQ QSDESIINEA
     FVKSIEVSAL TESDVSKVMG ALMRVQDLNI TQKLIERIYL TSDDSINSSI IRVHGYKTLS
     QTIKAFKDED KELISKILII LAKWPKVTRN KISSSQIEDV VKDINTNSND DNLKKLSSDL
     LAEWGKLQMA YRIPKNIGND KESNSPALYG RNARSRSRSR SPDRGKSAEP QHVETDEALP
     DGWQTAFDPN TQTNYYYHAE LGISKWERPI KEVPKGPKGP KALPVSEPIQ RPNSNSNGRS
     YNEEELTRRE EERLKREKEE QFKEIQQKER LLQELILQSQ KELEEKKSFE EKMKLEKLEK
     EKERQALKRK KLKKSKSSIP PAPPVPIDGQ WTKTFAKHVP NFLKKYEAEI GRDNIKGCAK
     ELVKTLVAKE MKKNPDTKPP KELDNAKLKK IKEYSKMFMD KFLIKYRSKH DKKRSHNEEN
     GGTKRVKPDV E
//
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