ID SIKE1_MOUSE Reviewed; 207 AA.
AC Q9CPR7; Q8CBP5;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 24-JAN-2024, entry version 129.
DE RecName: Full=Suppressor of IKBKE 1;
DE AltName: Full=Suppressor of IKK-epsilon;
GN Name=Sike1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Colon, Head, and Urinary bladder;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays
CC an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-
CC mediated activation of interferon-stimulated response elements (ISRE)
CC and the IFN-beta promoter. May act by disrupting the interactions of
CC IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-
CC kappa-B activation pathways (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with IKBKE and TBK1 via its coiled coil region.
CC Interaction with TBK1 is disrupted upon viral infection or TLR3
CC stimulation. Interacts with CDC42BPB. {ECO:0000250|UniProtKB:Q9BRV8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SIKE family. {ECO:0000305}.
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DR EMBL; AK014113; BAB29165.1; -; mRNA.
DR EMBL; AK014247; BAB29223.1; -; mRNA.
DR EMBL; AK017694; BAB30879.1; -; mRNA.
DR EMBL; AK019264; BAB31636.1; -; mRNA.
DR EMBL; AK033553; BAC28353.1; -; mRNA.
DR EMBL; AK035590; BAC29116.1; -; mRNA.
DR EMBL; BC004090; AAH04090.1; -; mRNA.
DR CCDS; CCDS17690.1; -.
DR RefSeq; NP_079955.1; NM_025679.3.
DR AlphaFoldDB; Q9CPR7; -.
DR SMR; Q9CPR7; -.
DR BioGRID; 211615; 1.
DR IntAct; Q9CPR7; 1.
DR STRING; 10090.ENSMUSP00000029447; -.
DR iPTMnet; Q9CPR7; -.
DR PhosphoSitePlus; Q9CPR7; -.
DR EPD; Q9CPR7; -.
DR MaxQB; Q9CPR7; -.
DR PaxDb; 10090-ENSMUSP00000029447; -.
DR PeptideAtlas; Q9CPR7; -.
DR ProteomicsDB; 261042; -.
DR Pumba; Q9CPR7; -.
DR Antibodypedia; 20165; 130 antibodies from 23 providers.
DR Ensembl; ENSMUST00000029447.12; ENSMUSP00000029447.6; ENSMUSG00000027854.13.
DR GeneID; 66641; -.
DR KEGG; mmu:66641; -.
DR UCSC; uc008qsf.1; mouse.
DR AGR; MGI:1913891; -.
DR CTD; 80143; -.
DR MGI; MGI:1913891; Sike1.
DR VEuPathDB; HostDB:ENSMUSG00000027854; -.
DR eggNOG; ENOG502QTKS; Eukaryota.
DR GeneTree; ENSGT00390000018003; -.
DR HOGENOM; CLU_073167_1_0_1; -.
DR InParanoid; Q9CPR7; -.
DR OMA; MSKFKPH; -.
DR OrthoDB; 5396923at2759; -.
DR PhylomeDB; Q9CPR7; -.
DR TreeFam; TF324337; -.
DR BioGRID-ORCS; 66641; 2 hits in 77 CRISPR screens.
DR ChiTaRS; Sike1; mouse.
DR PRO; PR:Q9CPR7; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9CPR7; Protein.
DR Bgee; ENSMUSG00000027854; Expressed in atrioventricular valve and 261 other cell types or tissues.
DR ExpressionAtlas; Q9CPR7; baseline and differential.
DR Genevisible; Q9CPR7; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; ISO:MGI.
DR GO; GO:0031267; F:small GTPase binding; ISO:MGI.
DR InterPro; IPR008555; SIKE.
DR PANTHER; PTHR12186; SIKE FAMILY MEMBER; 1.
DR PANTHER; PTHR12186:SF4; SUPPRESSOR OF IKBKE 1; 1.
DR Pfam; PF05769; SIKE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Cytoplasm; Reference proteome.
FT CHAIN 1..207
FT /note="Suppressor of IKBKE 1"
FT /id="PRO_0000299051"
FT COILED 70..102
FT /evidence="ECO:0000255"
FT COILED 164..192
FT /evidence="ECO:0000255"
FT CONFLICT 64
FT /note="M -> V (in Ref. 1; BAC29116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 207 AA; 23522 MW; FF12E0F36B948437 CRC64;
MSCTIEKILT DAKTLLERLR EHDAAAESLV DQSAALHRRV AAMREAGAVL PEQYQEDASD
VKDMSKYKPH ILLSQENTQI RDLQQENREL WVSLEEHQDA LELIMSKYRK QMLQLMVAKK
AVDAEPVLKA HQSHSAEIES QIDRICEMGA VMRRAVQVDD NQFCKVQERL AQLELENKEL
RELLSISSES LQVGKESSVA PASQTIK
//
