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Database: UniProt/SWISS-PROT
Entry: SODM_CUPMC
LinkDB: SODM_CUPMC
Original site: SODM_CUPMC 
ID   SODM_CUPMC              Reviewed;         197 AA.
AC   P17550; Q5NUZ9; Q93JN0;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 3.
DT   28-MAR-2018, entry version 116.
DE   RecName: Full=Superoxide dismutase [Fe];
DE            EC=1.15.1.1;
GN   Name=chrC; OrderedLocusNames=Rmet_6201; ORFNames=RMe0091;
OS   Cupriavidus metallidurans (strain ATCC 43123 / DSM 2839 / NBRC 102507
OS   / CH34) (Ralstonia metallidurans).
OG   Plasmid pMOL28.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=266264;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUPEROXIDE DISMUTASE ACTIVITY,
RP   SUGGESTION OF METAL-BINDING, SUBUNIT, AND INDUCTION.
RX   PubMed=12471500; DOI=10.1007/s00203-002-0492-5;
RA   Juhnke S., Peitzsch N., Huebener N., Grosse C., Nies D.H.;
RT   "New genes involved in chromate resistance in Ralstonia metallidurans
RT   strain CH34.";
RL   Arch. Microbiol. 179:15-25(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-69.
RX   PubMed=2180932;
RA   Nies A., Nies D.H., Silver S.;
RT   "Nucleotide sequence and expression of a plasmid-encoded chromate
RT   resistance determinant from Alcaligenes eutrophus.";
RL   J. Biol. Chem. 265:5648-5653(1990).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   van der Lelie D., Monchy S., Taghavi S., McCorkle S., Dunn J.,
RA   Benotmane M., Vallaeys T., Lapidus A., Mergeay M.;
RT   "Sequence and features of the Ralstonia metallidurans CH34 heavy metal
RT   plasmids pMOL28 and pMOL30.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43123 / DSM 2839 / NBRC 102507 / CH34;
RX   PubMed=20463976; DOI=10.1371/journal.pone.0010433;
RA   Janssen P.J., Van Houdt R., Moors H., Monsieurs P., Morin N.,
RA   Michaux A., Benotmane M.A., Leys N., Vallaeys T., Lapidus A.,
RA   Monchy S., Medigue C., Taghavi S., McCorkle S., Dunn J.,
RA   van der Lelie D., Mergeay M.;
RT   "The complete genome sequence of Cupriavidus metallidurans strain
RT   CH34, a master survivalist in harsh and anthropogenic environments.";
RL   PLoS ONE 5:E10433-E10433(2010).
CC   -!- FUNCTION: Destroys superoxide anion radicals which are normally
CC       produced within the cells and which are toxic to biological
CC       systems. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC       Note=Binds 1 Fe cation per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000305|PubMed:12471500}.
CC   -!- INDUCTION: By chromate; induction increases when cells are grown
CC       in the presence of high sulfate concentrations (3 mM NaSO4(2-)).
CC       {ECO:0000269|PubMed:12471500}.
CC   -!- MISCELLANEOUS: This protein is not essential for chromate
CC       resistance, however it may contribute to resistance under certain
CC       environmental conditions.
CC   -!- SIMILARITY: Belongs to the iron/manganese superoxide dismutase
CC       family. {ECO:0000305}.
DR   EMBL; X90708; CAI30235.1; -; Genomic_DNA.
DR   EMBL; CP000355; ABF13060.1; -; Genomic_DNA.
DR   EMBL; AJ313327; CAC42412.1; -; Genomic_DNA.
DR   PIR; C35177; C35177.
DR   RefSeq; WP_011239974.1; NC_007972.2.
DR   RefSeq; YP_161713.1; NC_006525.1.
DR   ProteinModelPortal; P17550; -.
DR   SMR; P17550; -.
DR   EnsemblBacteria; ABF13060; ABF13060; Rmet_6201.
DR   GeneID; 24148904; -.
DR   GeneID; 3187387; -.
DR   KEGG; rme:Rmet_6201; -.
DR   HOGENOM; HOG000013583; -.
DR   KO; K04564; -.
DR   OMA; YEHAYFI; -.
DR   OrthoDB; POG091H03Q7; -.
DR   Proteomes; UP000002429; Plasmid pMOL28.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IDA:CACAO.
DR   GO; GO:0046687; P:response to chromate; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.500.20; -; 1.
DR   InterPro; IPR001189; Mn/Fe_SOD.
DR   InterPro; IPR019832; Mn/Fe_SOD_C.
DR   InterPro; IPR036324; Mn/Fe_SOD_N_sf.
DR   InterPro; IPR036314; SOD_C_sf.
DR   Pfam; PF02777; Sod_Fe_C; 1.
DR   PIRSF; PIRSF000349; SODismutase; 1.
DR   SUPFAM; SSF46609; SSF46609; 1.
DR   SUPFAM; SSF54719; SSF54719; 1.
PE   1: Evidence at protein level;
KW   Chromate resistance; Complete proteome; Iron; Metal-binding;
KW   Oxidoreductase; Plasmid; Reference proteome.
FT   CHAIN         1    197       Superoxide dismutase [Fe].
FT                                /FTId=PRO_0000160011.
FT   METAL        26     26       Iron. {ECO:0000250}.
FT   METAL        75     75       Iron. {ECO:0000250}.
FT   METAL       157    157       Iron. {ECO:0000250}.
FT   METAL       161    161       Iron. {ECO:0000250}.
SQ   SEQUENCE   197 AA;  21565 MW;  D0F101A425DA38BD CRC64;
     MLYEMKPLGC EPAKLTGLSE KLIFSHYENN YGGAVKRLNA ITATLAELDM ATAPVFTLNG
     LKREELIATN SMILHEVYFD SLGDGGSLDG ALKTAIERDF GSVERWQAEF TAMGKALGGG
     SGWVLLTYSP RDGRLVNQWA SDHAHTLAGG TPVLALDMYE HSYHMDYGAK AAAYVDAFMQ
     NIHWQRAATR FAAAVRD
//
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