GenomeNet

Database: UniProt/SWISS-PROT
Entry: WDR62_PIG
LinkDB: WDR62_PIG
Original site: WDR62_PIG 
ID   WDR62_PIG               Reviewed;        1541 AA.
AC   Q8HXL3;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   26-FEB-2020, entry version 103.
DE   RecName: Full=WD repeat-containing protein 62;
GN   Name=WDR62;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11856879; DOI=10.1159/000048814;
RA   Droegemueller C., Kuiper H., Voss-Nemitz R., Brenig B., Distl O., Leeb T.;
RT   "Molecular characterization and chromosome assignment of the porcine gene
RT   COX7A1 coding for the muscle specific cytochrome c oxidase subunit VIIa-
RT   M.";
RL   Cytogenet. Cell Genet. 94:190-193(2001).
CC   -!- FUNCTION: Required for cerebral cortical development. Plays a role in
CC       neuronal proliferation and migration (By similarity). Plays a role in
CC       mother-centriole-dependent centriole duplication; the function seems
CC       also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled
CC       complex at the centrosome that recruits CDK2 required for centriole
CC       duplication (By similarity). {ECO:0000250|UniProtKB:O43379}.
CC   -!- SUBUNIT: Can form homodimers (via C-terminus). Interacts (via C-
CC       terminus) with MAPKBP1 (via C-terminus). Interacts with CDK5RAP2,
CC       CEP152, CEP63 and KIAA0753. CEP63, CDK5RAP2, CEP152, WDR62 are proposed
CC       to form a stepwise assembled complex at the centrosome forming a ring
CC       near parental centrioles. {ECO:0000250|UniProtKB:O43379}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43379}.
CC       Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:O43379}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000250|UniProtKB:O43379}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:O43379}. Note=Shows cell cycle-dependent
CC       localization. Accumulates to the spindle pole during mitosis (By
CC       similarity). Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete
CC       ring around the proximal end of the parental centriole. At this site, a
CC       cohesive structure is predicted to engage parental centrioles and
CC       procentrioles (By similarity). {ECO:0000250|UniProtKB:O43379}.
DR   EMBL; AJ410870; CAD56046.1; -; Genomic_DNA.
DR   RefSeq; NP_001121933.1; NM_001128461.1.
DR   STRING; 9823.ENSSSCP00000003147; -.
DR   PaxDb; Q8HXL3; -.
DR   PeptideAtlas; Q8HXL3; -.
DR   PRIDE; Q8HXL3; -.
DR   Ensembl; ENSSSCT00015041621; ENSSSCP00015016445; ENSSSCG00015031458.
DR   Ensembl; ENSSSCT00015041803; ENSSSCP00015016497; ENSSSCG00015031458.
DR   Ensembl; ENSSSCT00025082695; ENSSSCP00025035922; ENSSSCG00025060081.
DR   Ensembl; ENSSSCT00035043166; ENSSSCP00035017267; ENSSSCG00035032586.
DR   Ensembl; ENSSSCT00040102629; ENSSSCP00040046405; ENSSSCG00040074223.
DR   Ensembl; ENSSSCT00045041551; ENSSSCP00045028833; ENSSSCG00045024235.
DR   Ensembl; ENSSSCT00045041863; ENSSSCP00045029063; ENSSSCG00045024235.
DR   Ensembl; ENSSSCT00060093174; ENSSSCP00060040297; ENSSSCG00060068255.
DR   GeneID; 100144885; -.
DR   KEGG; ssc:100144885; -.
DR   CTD; 284403; -.
DR   eggNOG; KOG1408; Eukaryota.
DR   eggNOG; ENOG410Y87A; LUCA.
DR   InParanoid; Q8HXL3; -.
DR   KO; K21762; -.
DR   OrthoDB; 1017450at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   GO; GO:0005814; C:centriole; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR   GO; GO:0021987; P:cerebral cortex development; ISS:UniProtKB.
DR   GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR   GO; GO:0022008; P:neurogenesis; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 4.
DR   InterPro; IPR024977; Apc4_WD40_dom.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF12894; ANAPC4_WD40; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 12.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   3: Inferred from homology;
KW   Acetylation; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; WD repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   CHAIN           2..1541
FT                   /note="WD repeat-containing protein 62"
FT                   /id="PRO_0000281881"
FT   REPEAT          109..150
FT                   /note="WD 1"
FT   REPEAT          153..194
FT                   /note="WD 2"
FT   REPEAT          196..234
FT                   /note="WD 3"
FT   REPEAT          291..330
FT                   /note="WD 4"
FT   REPEAT          357..396
FT                   /note="WD 5"
FT   REPEAT          402..450
FT                   /note="WD 6"
FT   REPEAT          490..529
FT                   /note="WD 7"
FT   REPEAT          532..574
FT                   /note="WD 8"
FT   REPEAT          578..618
FT                   /note="WD 9"
FT   REPEAT          626..665
FT                   /note="WD 10"
FT   REPEAT          671..713
FT                   /note="WD 11"
FT   REPEAT          714..752
FT                   /note="WD 12"
FT   REPEAT          803..846
FT                   /note="WD 13"
FT   REPEAT          1138..1180
FT                   /note="WD 14"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         33
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         46
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         501
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         943
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3U3T8"
FT   MOD_RES         1050
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         1095
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         1125
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         1151
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         1235
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         1255
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         1256
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
FT   MOD_RES         1275
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:O43379"
SQ   SEQUENCE   1541 AA;  168899 MW;  81B8882854AF4F1E CRC64;
     MAALGTGGYV RNDAVEKLPT IMAGVPARRA QSSPPPAPPL CLRRRTRLTA APEDAVQNRV
     SLEKVLGITA QNSSGLTCDP GTGHVAYLAG CVVVILNPKE NKQQHILNTA RKSLSALAFS
     PDGKYIVTGE NGHRPAVRIW DVEEKNQVAE MLGHKYGVAC VAFSPNMKHI VSMGYQHDMV
     LNVWDWKKDI VVASNKVSCR VIALSFSEDS SYFVTVGNRH VRFWFLEVST EAKVTGTVPL
     VGRSGILGEL HDNVFCGVAC GRGQMAGSTF CVSYSGLLCQ FNEKRVLEKW INLKVSLSSC
     LCVSQELIFC GCTDGIVRIF QAHSLHYLAN LPKPHYLGVD VAQGLEPSFL FHRKAEAVYP
     DTVALTFDPN HQWLSCVYKD HSIYIWDVKD INKVGKMWSE LFHSSYVWNV EVYPEFEDQR
     ACLPSGSFLT CSSDNTIRFW NLDSNPDSHW QKNIFSDTLL KVVYVESDIQ HLQDMSHFPD
     RGSENGMAVD MKAGVRVMQV SPDGQHLASG DRSGNLRIHE LHFMDELVRV EAHDAEVLCL
     EYSKPETGLT LLASASRDRL IHVLNVEKNY SLEQTLDDHS SSITAVKFTG SRDIQMISCG
     ADKSIYFRSA QQASDGLHFV RTHHVAEKTT LYDMDIDITQ KYVAVACQDR NVRVYNTVNG
     KQKKCYKGSQ GDEGSLLKVH VDPSGTFLAT SCSDKSISVI DFYSGECVAK MFGHSEIITG
     MKFTYDCRHL ITVSGDSCVF IWHLGPEITN CMKQHLLEID QREQPQQNTK DGKWSRDPRQ
     ETCTSMPSEI SLSPGEQTED ELEEECEPEE LLKTPSKESL DSDPRCLLTN GKLPLWAKRL
     LGDDDVADGS AFHAKRSYQP HGRWAERADQ EPLKTILDAR DLDCYFTPMK PESLEDSILD
     TVESQRLAGL LSQSESPQED GCRHPSLTPP QRESSEVSEL LCSLESEVTI TGTDSKPCAE
     EGEGAPGDQQ DDFYLRVPSI TSKDLNPPED SGESEADLEC SFTAVHSPPR PDPDPPFDVA
     VPPAPGCPGA TEELARPEVP GLSNGSLPQT PEQEKFLRHH FETLTDAPAE ELFHGSLRDL
     KASEAKDDFF NPRLSISAQF LSRFQKPSRF THTFPTRLPR HPMQSPEVKL TDLAGSQPRA
     EPLRAGTGYT SPGRTNVLSA GKAEEPLEAW SPLTSCLTGL APCVSSSSVP PTDKTPPTPT
     ALPTPGLAQG VHTPATSSYV EATAGSRAKM SRSISLEDSK GPVLAELARP PCRPSSLGEL
     SSLGQELRAI TTTVTPSSDS EGQEPALPSR GNHEARASLK LTLSSICDRL LLPPPQLEPS
     AMCVWSQEPV AIQPNVMVTT ASFSAPSPVN VSASRLHNST FLPRFLAPEP LNTSAHPNSP
     PLPEARPGVP GNITSLLESA PDALSPVHRC PGHCGQPRVP ARVPPPGPLE LSNVGSIVHR
     LQTAFQEALD LYHMMVSRDE VSAEQQQAQT ELASTFLWIH SQLEANDWLV GTDGAPAQAL
     PSPGPPSPPT LCPLASPDLH ALLEHYSELL VQAVRRKAQR D
//
DBGET integrated database retrieval system