KEGG   Schizosaccharomyces pombe (fission yeast): SPBC2G2.08
Entry
SPBC2G2.08        CDS       T00076                                 
Symbol
ade9
Name
(RefSeq) trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase
  KO
K00288  methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Organism
spo  Schizosaccharomyces pombe (fission yeast)
Pathway
spo00670  One carbon pool by folate
spo01100  Metabolic pathways
spo01240  Biosynthesis of cofactors
Module
spo_M00141  C1-unit interconversion, eukaryotes
Brite
KEGG Orthology (KO) [BR:spo00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    SPBC2G2.08 (ade9)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:spo04147]
    SPBC2G2.08 (ade9)
Enzymes [BR:spo01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     SPBC2G2.08 (ade9)
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     SPBC2G2.08 (ade9)
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     SPBC2G2.08 (ade9)
Exosome [BR:spo04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   SPBC2G2.08 (ade9)
SSDB
Motif
Pfam: FTHFS THF_DHG_CYH_C THF_DHG_CYH AlaDh_PNT_C
Other DBs
NCBI-GeneID: 2540300
NCBI-ProteinID: NP_596437
PomBase: SPBC2G2.08
Ensembl: SPBC2G2.08
UniProt: O43007
Position
II:3448865..3452766
AA seq 972 aa
MNVMVSFNQLRNYFLESNSLRPSKWLFQSYGTSSSANILNGKLLARKLQRSVAEEVQALK
AKDRNFKPALAIVQVGKREDSNVYVRMKEKAARLVGIDFKYCPFPETIQMPALLHELKKL
NDDHTVHGVLVQLPLPKHLNERTVTESITPPKDVDGFGAFNIGLLAKNDATPIHYPCTPK
GIMELLKDNKISVAGLNAVVLGRSDIVGNPISYLLRKDNATVTVCHSKTKDLIQHISNAD
LVIAALGKPEFVRGEWLKPGSVVVDVGINAVQRNGKRVLVGDVHFESASKVASSITPVPG
GVGPMTVAMLMENIVNAAKIARTENIYRKIDLNPLELKKPVPSDIEIANSQEPKLISNLA
KEMGIYDTELENYGNYKAKVNLAVYERLKHRKDGNYVVVSGITPTPFGEGKSTVVAGLVQ
AMGHLGKLGIACVRQPSQGPTFGVKGGAAGGGYAQFIPMDDFNLHMTGDIHAVTAANNLL
VAALETRMFHENTQSDAALIKRLIPVKNGRRVIPRGLIGRWNRICASHNMDPEDVNNASP
ELLKEFVRLNVDPDTIECNRVLDVNDRFLRSIEVGKASTEKGHVRKTSFDISVASECMSI
LALSCDLNDMHSRLSRMVIANDKYGNAITAGDLGVSGALTVLLKDAIKPNLMQTLEGTPA
FVHAGPFANISIGASSIIADKIALKLAGTESFDRPEDAGYVVTEAGFASDMGMEKFFNIK
CRYSKLVPNTVVLVTTVKALKLHGGGPKLKPGAPIPEEYLVENLDLVKNGCSNMVKHIQN
CHKFNIPVVVAINSYKTDSSKEHEIIREAALQAGAVDAVPSDHWAQGGKGAIELAKSVMT
ACDQSSNSKFRLLYDSETSIEDKVNVIAKEMYGANGVEFSSLAKERINTFIKQGFGNLPI
CMAKTQYSLSHNPEFRNVPKNFTVPIRDMRLNAGAGFIYPLAAEIQTIPGLPTAPAYLNI
DICENGEIVGLS
NT seq 2919 nt   +upstreamnt  +downstreamnt
atgaacgtaatggtttcgtttaatcaattacgaaactattttctagaaagcaacagctta
cggccatcgaaatggctttttcagtcgtatggtacttcaagttctgcgaatatcctaaat
ggaaaattattggcaagaaaattacaacgttctgttgctgaagaagtgcaggccttgaaa
gctaaggatcgaaactttaagccggcgcttgccattgtacaggttggaaaacgtgaggat
tctaacgtgtacgttcgaatgaaagaaaaggcggcacgattagttggtattgattttaaa
tactgcccgtttcctgaaacaatccaaatgcctgccttgcttcatgaattaaaaaaattg
aatgacgatcatacggttcacggtgtccttgtccaacttcctcttcccaagcatctcaat
gagcgtacagttactgaatctatcactccgccgaaagacgttgatggatttggtgcattt
aacattggtttattggcaaagaatgatgctacccccattcattatccctgtaccccgaaa
ggtattatggagttattaaaagataacaagatttcagtcgctggattgaacgctgtagtt
ctgggaagaagtgacattgtcggaaatccaattagctacttgttgagaaaggacaatgct
acagtaactgtctgtcattctaaaactaaagatttaattcagcacatttctaatgctgat
ttggttatagcagcattaggcaaacccgaatttgttcgtggtgaatggttgaaaccagga
tctgttgtggtagatgttggcataaacgctgttcaaagaaatggaaaacgcgttttggtt
ggcgatgtgcatttcgaatctgcatccaaagttgctagcagcattactcctgtccctgga
ggcgtcggaccgatgactgttgctatgctaatggaaaatattgtaaacgctgccaagata
gctagaacagaaaacatttatcgaaaaattgacttaaatcctttagagttaaagaagcct
gttccttctgatatcgaaattgctaattcccaagaacctaaattaattagcaatcttgct
aaggagatgggtatctatgacacagagttagaaaattatgggaactataaggcaaaagta
aatcttgctgtttatgaacgtttaaagcaccgaaaagatgggaactatgttgttgtaagt
ggtattactcctacaccttttggcgaaggtaaaagtacagttgttgctggtttggttcaa
gctatgggccatttgggtaagcttggaattgcttgtgtccgtcagccgtcccaagggccg
acatttggtgttaaaggaggcgccgctggtggaggctacgcacaatttattcctatggat
gactttaaccttcatatgactggagatatacacgctgttaccgcagcaaataatctttta
gtcgcggctcttgaaactaggatgtttcatgaaaacacacaatctgatgctgcccttata
aaacgtttgatccctgttaaaaacgggcgaagagtcattccacgaggattgatcggtagg
tggaatcgtatttgcgcatctcataacatggatccagaagatgttaataacgcatcaccg
gaattactgaaagagtttgtgcggctaaacgtagatcctgacaccatcgaatgcaacaga
gtattggacgtcaatgatcgattcctccgttctattgaggttggaaaagcatcaactgaa
aagggacatgtccgtaaaacttctttcgatatctctgtggccagtgaatgcatgtcaatt
ctggctctttcatgtgatttaaacgacatgcattctcgtttatcccgtatggttatagcc
aacgacaaatacggaaatgctattactgctggcgaccttggagtttctggagcattgacc
gttttgcttaaagacgctatcaaacctaacttgatgcaaactttggaaggaacaccagcg
tttgttcacgcaggaccttttgcaaacattagcattggcgcgtcttctattatcgctgat
aaaattgctttaaaattggctggtacagaaagctttgacagacccgaagatgccggctat
gtcgttaccgaagcaggatttgcgtctgacatgggaatggaaaaattctttaacatcaaa
tgtagatactcaaaacttgtacctaacaccgttgttttggttaccactgttaaagcgctt
aagttacatggaggcggtcccaagttaaaacctggtgccccaattcctgaggaatatctt
gttgaaaatctagaccttgtaaagaatggatgttccaacatggtaaaacacattcaaaat
tgtcataaattcaatattcctgttgttgtcgccatcaacagttataagactgatagttct
aaggagcatgaaataatacgcgaggcagcgctacaagctggagctgtggatgctgtacct
tcggatcattgggcccaaggcggcaaaggagctattgaattggccaagtccgtaatgacg
gcttgtgatcagtcatccaattcgaagtttaggcttttgtatgatagcgagacttcaatt
gaagataaagtaaatgtgattgcaaaagaaatgtatggagcaaacggtgttgaatttagt
tctctagctaaggaacgaataaatacgtttatcaaacaagggttcggtaacttaccaatt
tgcatggcgaaaacccaatattctctttcgcataatcccgaatttcgcaatgttccaaaa
aattttacagttcctattagagatatgcgtttgaatgctggcgctggcttcatttatccg
ctagctgctgaaatccaaacaattcctggtttaccgactgcgcctgcctatttaaacatt
gatatatgtgaaaatggagaaattgttgggctgtcataa

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (3)   
   KEGG MODULE (1)   
Chemical substance (12)   
   KEGG COMPOUND (12)   
Chemical reaction (6)   
   KEGG ENZYME (3)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (32)   
   KEGG ORTHOLOGY (1)   
   RefGene (23)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (3)   
   OC (1)   
   POMBASE (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (4)   
   Pfam (4)   
All databases (66)   

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