KEGG   Streptococcus pneumoniae R6 (avirulent serotype 2): spr0178
Entry
spr0178           CDS       T00060                                 
Symbol
folC
Name
(GenBank) Dihydrofolate:folylpolyglutamate synthetase
  KO
K11754  dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
Organism
spr  Streptococcus pneumoniae R6 (avirulent serotype 2)
Pathway
spr00790  Folate biosynthesis
spr01100  Metabolic pathways
spr01240  Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:spr00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    spr0178 (folC)
Enzymes [BR:spr01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.12  dihydrofolate synthase
     spr0178 (folC)
    6.3.2.17  tetrahydrofolate synthase
     spr0178 (folC)
SSDB
Motif
Pfam: Mur_ligase_M Mur_ligase_C
Other DBs
NCBI-ProteinID: AAK98982
UniProt: Q8DRE0
Position
185813..187069
AA seq 418 aa
MCMFEVKEWLHSRIGLNFRSGLGRMQQAVDLLGNPEQSYPIIHVTGTNGKGSTIAFMREL
FMGHGKKVATFTSPHIVSINDRICINGQPIADADFIRLADQVKEMEKTLLQTPDQLSFFE
LLTLVAFLYFRGQEVDLVLLEVGIGGLLDTTNVVTGELAVITSIGLDHQETLGDSLEAIA
EQKAGIFKAGKKAVIAKLPPEARLVCQKKAESLAVNLYQAGQDFSVLNGDFSSSLLNLSQ
LNIGLEGVYQQENAALALQTFLLFMGEGKEAVDEQAVRKALEQTHWAGRLERIRPQIYLD
GAHNLPALTRLVEFIKEKEQEGYRPQILFGSLKRKDYQGMLGYLTENLPQVELKMTGFDY
QGSLDETDVTGYHVIPSYREFISSFEERADAQDLLFVTGSLYFISEVRGYLLDREQIN
NT seq 1257 nt   +upstreamnt  +downstreamnt
atgtgtatgtttgaagtaaaagaatggctccatagtcggattggtttgaattttcgatca
ggtttgggccgaatgcagcaagcggtggatttgttaggaaatcctgagcagtcttaccct
attatccacgtaacagggactaatgggaaaggatctaccattgcttttatgagggaatta
tttatggggcatggcaaaaaagttgcgacctttacctcccctcatatcgtctctatcaat
gaccgaatctgcattaatgggcaacctatagcagacgcagactttatccgtttggctgat
caggtcaaggagatggagaaaacgcttctgcaaactcctgaccagttgtccttttttgaa
ttgctgaccttagttgcttttctttattttagggggcaagaggtggatttggttttatta
gaagtgggaattggtggcttacttgacacgaccaatgtggtaactggagagcttgctgtc
atcacctccattgggcttgaccatcaagaaaccttgggtgatagtctagaagcaattgca
gagcagaaagctggtattttcaaggctggtaagaaggcagtgattgcgaaattgcctcca
gaagctaggcttgtctgtcagaaaaaagccgaatctttagctgttaacctttatcaggca
ggtcaagatttttcagtgctgaatggtgatttttcaagctctttactaaatctttcacag
ctgaacataggcttagaaggagtctatcagcaggagaatgcagccttggcgttgcaaact
tttcttctttttatgggagaaggaaaggaagctgttgatgaacaggctgtaagaaaggcc
ttggaacagacccattgggctggtcgcttggagcgtattcgcccacagatttacttggat
ggtgctcataacctccctgccttgactcgcttggttgagtttatcaaagaaaaagagcag
gaaggctatcgacctcaaatcctctttggatccttgaaacgtaaggattatcaagggatg
ttgggttatctgactgaaaatttacctcaagtggaactcaaaatgaccggctttgactat
caagggtctttggacgagacagatgtaacaggttaccatgtaattccctcttaccgagaa
tttatcagcagtttcgaagaaagggcagacgctcaagacttgctgttcgttacagggtct
ctctattttatctcagaagtacggggctacctgctggaccgtgagcagataaattga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (5)   
   KEGG PATHWAY (3)   
   KEGG MODULE (2)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (5)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (2)   
   Pfam (2)   
All databases (28)   

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