KEGG   Sus scrofa (pig): 100192436
Entry
100192436         CDS       T01009                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2
  KO
K04364  growth factor receptor-binding protein 2
Organism
ssc  Sus scrofa (pig)
Pathway
ssc01521  EGFR tyrosine kinase inhibitor resistance
ssc01522  Endocrine resistance
ssc04010  MAPK signaling pathway
ssc04012  ErbB signaling pathway
ssc04014  Ras signaling pathway
ssc04062  Chemokine signaling pathway
ssc04068  FoxO signaling pathway
ssc04072  Phospholipase D signaling pathway
ssc04150  mTOR signaling pathway
ssc04151  PI3K-Akt signaling pathway
ssc04380  Osteoclast differentiation
ssc04510  Focal adhesion
ssc04540  Gap junction
ssc04550  Signaling pathways regulating pluripotency of stem cells
ssc04630  JAK-STAT signaling pathway
ssc04650  Natural killer cell mediated cytotoxicity
ssc04660  T cell receptor signaling pathway
ssc04662  B cell receptor signaling pathway
ssc04664  Fc epsilon RI signaling pathway
ssc04714  Thermogenesis
ssc04722  Neurotrophin signaling pathway
ssc04910  Insulin signaling pathway
ssc04912  GnRH signaling pathway
ssc04915  Estrogen signaling pathway
ssc04917  Prolactin signaling pathway
ssc04926  Relaxin signaling pathway
ssc04935  Growth hormone synthesis, secretion and action
ssc05034  Alcoholism
ssc05160  Hepatitis C
ssc05161  Hepatitis B
ssc05163  Human cytomegalovirus infection
ssc05165  Human papillomavirus infection
ssc05200  Pathways in cancer
ssc05203  Viral carcinogenesis
ssc05205  Proteoglycans in cancer
ssc05206  MicroRNAs in cancer
ssc05210  Colorectal cancer
ssc05211  Renal cell carcinoma
ssc05213  Endometrial cancer
ssc05214  Glioma
ssc05215  Prostate cancer
ssc05220  Chronic myeloid leukemia
ssc05221  Acute myeloid leukemia
ssc05223  Non-small cell lung cancer
ssc05224  Breast cancer
ssc05225  Hepatocellular carcinoma
ssc05226  Gastric cancer
ssc05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ssc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    100192436 (GRB2)
   04012 ErbB signaling pathway
    100192436 (GRB2)
   04014 Ras signaling pathway
    100192436 (GRB2)
   04630 JAK-STAT signaling pathway
    100192436 (GRB2)
   04068 FoxO signaling pathway
    100192436 (GRB2)
   04072 Phospholipase D signaling pathway
    100192436 (GRB2)
   04151 PI3K-Akt signaling pathway
    100192436 (GRB2)
   04150 mTOR signaling pathway
    100192436 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    100192436 (GRB2)
   04540 Gap junction
    100192436 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    100192436 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    100192436 (GRB2)
   04660 T cell receptor signaling pathway
    100192436 (GRB2)
   04662 B cell receptor signaling pathway
    100192436 (GRB2)
   04664 Fc epsilon RI signaling pathway
    100192436 (GRB2)
   04062 Chemokine signaling pathway
    100192436 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    100192436 (GRB2)
   04912 GnRH signaling pathway
    100192436 (GRB2)
   04915 Estrogen signaling pathway
    100192436 (GRB2)
   04917 Prolactin signaling pathway
    100192436 (GRB2)
   04926 Relaxin signaling pathway
    100192436 (GRB2)
   04935 Growth hormone synthesis, secretion and action
    100192436 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    100192436 (GRB2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    100192436 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    100192436 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    100192436 (GRB2)
   05206 MicroRNAs in cancer
    100192436 (GRB2)
   05205 Proteoglycans in cancer
    100192436 (GRB2)
   05203 Viral carcinogenesis
    100192436 (GRB2)
   05231 Choline metabolism in cancer
    100192436 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    100192436 (GRB2)
   05225 Hepatocellular carcinoma
    100192436 (GRB2)
   05226 Gastric cancer
    100192436 (GRB2)
   05214 Glioma
    100192436 (GRB2)
   05221 Acute myeloid leukemia
    100192436 (GRB2)
   05220 Chronic myeloid leukemia
    100192436 (GRB2)
   05211 Renal cell carcinoma
    100192436 (GRB2)
   05215 Prostate cancer
    100192436 (GRB2)
   05213 Endometrial cancer
    100192436 (GRB2)
   05224 Breast cancer
    100192436 (GRB2)
   05223 Non-small cell lung cancer
    100192436 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    100192436 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    100192436 (GRB2)
   05160 Hepatitis C
    100192436 (GRB2)
   05163 Human cytomegalovirus infection
    100192436 (GRB2)
   05165 Human papillomavirus infection
    100192436 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    100192436 (GRB2)
   01522 Endocrine resistance
    100192436 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:ssc04131]
    100192436 (GRB2)
Membrane trafficking [BR:ssc04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    100192436 (GRB2)
SSDB
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 SH3_3 DUF5093 hSH3 SH3_4
Other DBs
NCBI-GeneID: 100192436
NCBI-ProteinID: NP_001131100
Ensembl: ENSSSCG00000017206
Vega: OTTSUSG00000000932
UniProt: B6E241 A0A4X1UZ70
Position
12
AA seq 217 aa
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt   +upstreamnt  +downstreamnt
atggaagccatcgccaagtatgacttcaaagccaccgcagacgacgagctgagcttcaaa
aggggggacatcctcaaggttttgaatgaagaatgtgatcagaactggtacaaagcagag
ctcaatgggaaagatggcttcatccccaagaactacatagaaatgaaaccacacccgtgg
ttttttggcaaaatccccagagccaaggcagaagaaatgcttagcaaacagcggcacgat
ggggcctttctcatccgtgagagcgagagcgctcctggggatttctccctctctgtcaag
tttggcaatgatgtgcagcacttcaaggtgctccgggacggcgctggcaagtacttcctc
tgggtggtgaagttcaattctttgaatgagctggtagattatcacagatctacatccgtc
tccagaaaccagcagatattcctccgggacatagaacaggtgccacagcaaccgacatac
gtccaggccctctttgactttgacccccaggaggatggtgagctgggcttccgtcgggga
gactttatccacgtcatggataactcggaccccaactggtggaagggggcttgccacggg
cagaccggcatgtttccgcgcaattacgtcacccctgtgaaccggaacgtctaa

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