KEGG   Trichechus manatus latirostris (Florida manatee): 101346612
Entry
101346612         CDS       T05135                                 
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 5 isoform X1
  KO
K04426  mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
Organism
tmu  Trichechus manatus latirostris (Florida manatee)
Pathway
tmu01524  Platinum drug resistance
tmu04010  MAPK signaling pathway
tmu04071  Sphingolipid signaling pathway
tmu04141  Protein processing in endoplasmic reticulum
tmu04210  Apoptosis
tmu04530  Tight junction
tmu04668  TNF signaling pathway
tmu04714  Thermogenesis
tmu04722  Neurotrophin signaling pathway
tmu04932  Non-alcoholic fatty liver disease
tmu04936  Alcoholic liver disease
tmu05010  Alzheimer disease
tmu05012  Parkinson disease
tmu05014  Amyotrophic lateral sclerosis
tmu05016  Huntington disease
tmu05017  Spinocerebellar ataxia
tmu05022  Pathways of neurodegeneration - multiple diseases
tmu05208  Chemical carcinogenesis - reactive oxygen species
tmu05417  Lipid and atherosclerosis
tmu05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tmu00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    101346612
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101346612
   04668 TNF signaling pathway
    101346612
   04071 Sphingolipid signaling pathway
    101346612
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    101346612
  09144 Cellular community - eukaryotes
   04530 Tight junction
    101346612
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101346612
  09159 Environmental adaptation
   04714 Thermogenesis
    101346612
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    101346612
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101346612
   05012 Parkinson disease
    101346612
   05014 Amyotrophic lateral sclerosis
    101346612
   05016 Huntington disease
    101346612
   05017 Spinocerebellar ataxia
    101346612
   05022 Pathways of neurodegeneration - multiple diseases
    101346612
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101346612
   05418 Fluid shear stress and atherosclerosis
    101346612
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101346612
   04932 Non-alcoholic fatty liver disease
    101346612
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    101346612
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tmu01001]
    101346612
Enzymes [BR:tmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     101346612
Protein kinases [BR:tmu01001]
 Serine/threonine kinases: STE group
  STE11 family
   101346612
SSDB
Motif
Pfam: MAP3K_TRAF_bd Pkinase HisK-N-like PK_Tyr_Ser-Thr ASK_PH TPR-S DRHyd-ASK FPP Kinase-like Pkinase_fungal
Other DBs
NCBI-GeneID: 101346612
NCBI-ProteinID: XP_004368947
UniProt: A0A2Y9D6X7
Position
Unknown
AA seq 1374 aa
MGTEAGEGITFSVPRFGSLGLCTFAEGGSCRRGGAAATVEGEENQQPPPPPGSFWNVESA
AGPGTGCPAASSGGSATRSRGNSGGGGGRQTTVAYVINEASQGQLVVAESEALQSLREAC
EAVGAALETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN
IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP
NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR
QRIDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN
RRNLPGDRAKALDIMIPLVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDLGASWFK
KAFESEPTLQSGINYAVLLLATGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF
FLGASVLANDHLRVIQASEKLFKLKTPAWYLKSIVETILIYKHFAKLTTEQPVVKQELVD
FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH
EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS
AEEGDCESDSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
GFYTKQILEGLRYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
PEIPESMSAEAKAFILKCFEPDPDKRACANDLLMNEFLKVSSKKKKTQPKLSALSAGSNE
YLRSISLPVPVLVEDTSSSSEYGSVSPDNELKVDPFSFKTRPKSCGEKDVKGIRTLFLGI
PDENFEDHSAPPSPEEKDSGFFLLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEP
KLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNK
VLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEE
QPSNQTVRRPHAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELV
RKEKELQALLHQAIEEKDQEIKHLKLKSQPIDIPGLPVCHLNSPGINTEDPELTDWLREN
GADEDTISRFLAEDYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIADFRDKQP
NT seq 4125 nt   +upstreamnt  +downstreamnt
atgggcacggaggcgggcgagggcatcactttctccgtgccacgtttcggctctttgggc
ttatgcaccttcgccgagggcggcagctgccggaggggaggagcggcggcgacggtggag
ggcgaggagaaccagcagccaccgccgccacccggtagtttctggaacgtggagagcgcc
gccggccctggcaccggctgtcccgctgccagctccgggggcagcgccactcggagccgg
ggcaactctggtggcggaggcggccgacagaccactgtggcatatgtgattaacgaagcg
agccaggggcagctggtggtggccgagagtgaggccctgcagagcctgcgggaggcgtgc
gaggctgtgggcgccgcgctggagaccctgcattttggtaaactggactttggggaaacc
acggtgctggaccgcttttacaatgcagatatcgctgtggtggagatgagtgatgccttc
cggcagccatccttgttttaccaccttggggtgagagaaagtttcagcatggccaacaac
atcatcctctactgtgatactaactcagactctctgcagtcactgaaggaaatcatttgc
cagaagaataccatgtgcactgggaactacacgtttgttccttacatgataactccacat
aacaaggtctactgctgtgacagcagcttcatgaaggggttgacagagctaatgcaaccg
aacttcgagctgcttcttggacccatctgcttacctcttgtggatcgttttattcagctt
ttgaaggtggcacaagcaagttctagccagtatttccgggaatctatactcaatgatatt
aggaaagctcgtaacttgtacactggtaaagaattggcagctgaattggcaagaatccgg
cagcgaatagacaatatcgaagtcttgacagcagatattgtgataaatctcttactttct
tacagagacattcaggattatgactctattgtgaagctggtagagacattagaaaaactg
ccaacctttgatttggcctcccatcaccatgtgaagtttcattatgcgtttgcactgaat
aggagaaatctccctggagatagagcaaaagctcttgatattatgattcccctggtgcaa
agtgaaggacaagttgcttcagatatgtattgcctagtgggtcgaatctacaaagatatg
tttttggactctaatttcacagacactgaaagtagagaccttggagcctcttggttcaaa
aaggcatttgaatctgagccaacactacagtcaggaattaattatgcggtccttctcctg
gcaactgggcaccagtttgaatcttcctttgagctccggaaagttggcgtgaagctaagt
agccttcttggtaaaaagggaaacttggaaaaactccagagctactgggaagttggattt
tttctgggggccagtgtcctggccaatgaccacttgagagtcattcaagcatctgaaaag
ctttttaaactgaagacaccagcatggtacctcaagtctattgtagagacaattttgata
tataagcattttgcaaaactgaccacagaacagcctgtggtgaagcaggaacttgtggac
ttctggatggatttcctggtcgaggccacaaagacagatgttactgtagttaggtttcct
gtattaatattagaaccaaccaagatctaccaaccttcttatttgtctatcaacaatgaa
gtcgaggaaaagacaatatctatttggcatgtgcttcctgatgacaagaaaggtatacat
gagtggaatttcagtgcctcttctgtcaggggagtgagtatttctaaatttgaagaacga
tgctgttttctttatgtgcttcataattctgatgatttccaaatctacttctgtacagaa
cttcactgtaaaaagttttttgaaatggtgaataccattactgaagagaaggggagaagc
gccgaggaaggggattgtgaaagtgactccctggagtatgactatgaatatgatgaaaac
ggtgacagagtcgttttaggaaaaggcacttacggcatagtctatgcaggtcgagacttg
agcaaccaagtcagaattgctattaaggaaatcccagagagagatagcagatactcgcag
cccctacatgaagaaatagcattgcataagcatctgaaacacaaaaatattgtccagtat
ctgggctcttttagtgagaatggcttcattaaaatcttcatggagcaggtcccaggagga
agtctttctgctctccttcgttccaaatggggcccattaaaagacaatgagcaaacaatt
ggcttttatacaaagcaaatacttgaaggattaagatacctccacgacaatcagatagtt
caccgggatataaagggtgacaatgtgttgattaatacctatagtggtgttctcaagatc
tccgacttcgggacatcaaagaggttggctggcataaatccatgtactgaaactttcact
ggtacccttcagtacatggcaccagaaataatagataaagggcccagaggctacggaaaa
gcagcagacatctggtctttgggctgcaccatcattgaaatggccacaggaaaaccaccc
ttttatgaactaggagaaccacaagcagctatgttcaaggtgggaatgtttaaagtccac
ccggagattcctgagtccatgtcagcagaggccaaggcattcatattgaaatgttttgaa
ccagatccagacaagagagcatgtgctaatgacttgctgatgaatgagttcttaaaagtg
tcaagcaaaaagaaaaagacacaacctaagctttcagccctttcagctggatcaaatgaa
tatcttaggagtatatccctaccggtccctgtcctggtcgaagatacgagcagcagtagt
gaatatggctcagtttcacctgacaatgagttaaaagtggaccccttctctttcaaaaca
agacccaaatcctgtggagaaaaagatgtaaaaggaatacggacactctttttgggcatt
ccagatgaaaattttgaagatcacagtgctccaccttcccctgaagaaaaagattccggt
ttctttctgttgaggaaggacagtgaaagaagagctactcttcacaggatcctaacagaa
gaccaagacaaaatcgtgagaaatttaatggagtctttggctcagggggctgaagaacct
aaactaaagtgggaacacatcacaaccctcatcgcaagcctcagagaatttgtgagatcc
actgaccgaaaaatcatagccaccactctgtcaaagctgaagctagagctagacttcgac
agccacggcatcagtcaagttcaagtggttctctttggttttcaagatgctgtcaataag
gttcttcggaatcataacatcaagccacactggatgtttgccttggacagtatcatccgg
aaggcggtgcagacagccattaccatcctggttccagaactgaggccacattttagcctt
gcatctgagagtgataccgctgatcaagaagacttggatgtagaagatgaccatgaggaa
cagccttcaaatcaaactgttcgaagacctcatgccgtcattgaagatgctgtggctacc
tcgggggtgagcacgctcagttctactgtgtcccacgattcccagagtgctcaccggtca
ctgaatgtacagcttggaaggatgaaaatagaaactaatagattactggaagaattggtt
cggaaagagaaagaattacaagcactccttcatcaagctattgaagagaaagaccaagaa
attaaacacctgaagttgaagtcccaaccaatagatattcctggattacctgtgtgtcac
ctaaattctcctggcataaatactgaagatcctgaacttactgactggctgagagaaaat
ggagctgacgaagacactataagccggtttctggctgaggattatacactagtggatgtt
ctctactatgttacacgtgatgatttaaaatgcctgagactaagaggcgggatgctatgc
acactgtggaaggccatcgctgactttcgagacaaacagccttga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (13)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (8)   
   UniProt (1)   
   RefSeq(pep) (7)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (10)   
   Pfam (10)   
All databases (67)   

Download RDF
DBGET integrated database retrieval system