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Database: UniProt/TrEMBL
Entry: A0A077DB40_LARCR
LinkDB: A0A077DB40_LARCR
Original site: A0A077DB40_LARCR 
ID   A0A077DB40_LARCR        Unreviewed;       154 AA.
AC   A0A077DB40;
DT   29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 1.
DT   28-FEB-2018, entry version 16.
DE   RecName: Full=Superoxide dismutase [Cu-Zn] {ECO:0000256|RuleBase:RU000393};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000393};
GN   Name=SOD1 {ECO:0000313|EMBL:AIL29307.1};
GN   ORFNames=EH28_08432 {ECO:0000313|EMBL:KKF19728.1};
OS   Larimichthys crocea (Large yellow croaker) (Pseudosciaena crocea).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Sciaenidae; Larimichthys.
OX   NCBI_TaxID=215358 {ECO:0000313|EMBL:AIL29307.1};
RN   [1] {ECO:0000313|EMBL:AIL29307.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=EC01 {ECO:0000313|EMBL:AIL29307.1};
RC   TISSUE=Liver {ECO:0000313|EMBL:AIL29307.1};
RX   PubMed=25652289; DOI=10.1016/j.fsi.2015.01.032;
RA   Liu H., He J., Chi C., Gu Y.;
RT   "Identification and analysis of icCu/Zn-SOD, Mn-SOD and ecCu/Zn-SOD in
RT   superoxide dismutase multigene family of Pseudosciaena crocea.";
RL   Fish Shellfish Immunol. 43:491-501(2015).
RN   [2] {ECO:0000313|EMBL:KKF19728.1, ECO:0000313|Proteomes:UP000054355}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSNF {ECO:0000313|EMBL:KKF19728.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:KKF19728.1};
RX   PubMed=25835551;
RA   Ao J., Mu Y., Xiang L.X., Fan D., Feng M., Zhang S., Shi Q., Zhu L.Y.,
RA   Li T., Ding Y., Nie L., Li Q., Dong W.R., Jiang L., Sun B., Zhang X.,
RA   Li M., Zhang H.Q., Xie S., Zhu Y., Jiang X., Wang X., Mu P., Chen W.,
RA   Yue Z., Wang Z., Wang J., Shao J.Z., Chen X.;
RT   "Genome Sequencing of the Perciform Fish Larimichthys crocea Provides
RT   Insights into Molecular and Genetic Mechanisms of Stress Adaptation.";
RL   PLoS Genet. 11:E1005118-E1005118(2015).
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000393}.
CC   -!- CATALYTIC ACTIVITY: 2 superoxide + 2 H(+) = O(2) + H(2)O(2).
CC       {ECO:0000256|RuleBase:RU000393}.
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 copper ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.
CC       {ECO:0000256|RuleBase:RU000393}.
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DR   EMBL; KJ908287; AIL29307.1; -; mRNA.
DR   EMBL; KQ042000; KKF19728.1; -; Genomic_DNA.
DR   RefSeq; NP_001290289.1; NM_001303360.1.
DR   GeneID; 104923808; -.
DR   KEGG; lco:104923808; -.
DR   CTD; 6647; -.
DR   KO; K04565; -.
DR   Proteomes; UP000054355; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   CDD; cd00305; Cu-Zn_Superoxide_Dismutase; 1.
DR   Gene3D; 2.60.40.200; -; 1.
DR   InterPro; IPR036423; SOD-like_Cu/Zn_dom_sf.
DR   InterPro; IPR024134; SOD_Cu/Zn_/chaperone.
DR   InterPro; IPR018152; SOD_Cu/Zn_BS.
DR   InterPro; IPR001424; SOD_Cu_Zn_dom.
DR   PANTHER; PTHR10003; PTHR10003; 1.
DR   Pfam; PF00080; Sod_Cu; 1.
DR   PRINTS; PR00068; CUZNDISMTASE.
DR   SUPFAM; SSF49329; SSF49329; 1.
DR   PROSITE; PS00087; SOD_CU_ZN_1; 1.
DR   PROSITE; PS00332; SOD_CU_ZN_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000054355};
KW   Copper {ECO:0000256|RuleBase:RU000393};
KW   Metal-binding {ECO:0000256|RuleBase:RU000393};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000393};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054355};
KW   Zinc {ECO:0000256|RuleBase:RU000393}.
FT   DOMAIN       12    150       Sod_Cu. {ECO:0000259|Pfam:PF00080}.
SQ   SEQUENCE   154 AA;  15794 MW;  EFC0A8A4EA5667ED CRC64;
     MVLKAVCVLK GDGEVGGTVF FEQENDSAPV TVTGEIKGLQ PGDHGFHVHA FGDNTNGCIS
     AGPHFNPHNK NHAGPTDAER HVGDLGNVTA GADNVAKISI TDSMITLTGP ISIIGRTMVI
     HEKADDLGKG GNEESLKTGN AGSRLACGVI GIAQ
//
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