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Database: UniProt/TrEMBL
Entry: A0A0H2YR00_CLOP1
LinkDB: A0A0H2YR00_CLOP1
Original site: A0A0H2YR00_CLOP1 
ID   A0A0H2YR00_CLOP1        Unreviewed;       464 AA.
AC   A0A0H2YR00;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   25-APR-2018, entry version 20.
DE   RecName: Full=Glutamate decarboxylase {ECO:0000256|RuleBase:RU361171};
DE            EC=4.1.1.15 {ECO:0000256|RuleBase:RU361171};
GN   OrderedLocusNames=CPF_2315 {ECO:0000313|EMBL:ABG82826.1};
OS   Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 /
OS   NCIMB 6125 / NCTC 8237 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195103 {ECO:0000313|EMBL:ABG82826.1, ECO:0000313|Proteomes:UP000001823};
RN   [1] {ECO:0000313|EMBL:ABG82826.1, ECO:0000313|Proteomes:UP000001823}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / S
RC   107 / Type A {ECO:0000313|Proteomes:UP000001823};
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S., Rasko D.A., Cheung J.K., Ravel J., Seshadri R.,
RA   Deboy R.T., Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C.,
RA   Haft D.H., Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J.,
RA   Sullivan S.A., Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S.,
RA   Benton J., Radune D., Fisher D.J., Atkins H.S., Hiscox T., Jost B.H.,
RA   Billington S.J., Songer J.G., McClane B.A., Titball R.W., Rood J.I.,
RA   Melville S.B., Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial
RT   pathogen, Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
CC   -!- CATALYTIC ACTIVITY: L-glutamate = 4-aminobutanoate + CO(2).
CC       {ECO:0000256|RuleBase:RU361171}.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|PIRSR:PIRSR602129-50,
CC         ECO:0000256|RuleBase:RU000382};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU000382}.
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DR   EMBL; CP000246; ABG82826.1; -; Genomic_DNA.
DR   RefSeq; WP_003455061.1; NC_008261.1.
DR   ProteinModelPortal; A0A0H2YR00; -.
DR   STRING; 195103.CPF_2315; -.
DR   EnsemblBacteria; ABG82826; ABG82826; CPF_2315.
DR   GeneID; 29570578; -.
DR   KEGG; cpf:CPF_2315; -.
DR   KO; K01580; -.
DR   OMA; RPNLVMG; -.
DR   Proteomes; UP000001823; Chromosome.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR43321; PTHR43321; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR01788; Glu-decarb-GAD; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001823};
KW   Decarboxylase {ECO:0000256|RuleBase:RU361171};
KW   Lyase {ECO:0000256|RuleBase:RU000382, ECO:0000313|EMBL:ABG82826.1};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU000382}.
FT   MOD_RES     276    276       N6-(pyridoxal phosphate)lysine.
FT                                {ECO:0000256|PIRSR:PIRSR602129-50}.
SQ   SEQUENCE   464 AA;  52940 MW;  1B242027E4787DAE CRC64;
     MLFGKNELGS QFETPIFGTV ESNESIPKYE LAKKSIAPQV AYRLIKDDLL DEGNARQNLC
     TFCQTYMDDE AVKLMAETLE KNAIDKSEYP QTTDLENRCV NILADLWHAP KDESFMGTST
     VGSSEACMLG GMAMKFRWRN RAKALGMDVT SRKPNLVISS GYQVCWEKFC VYWDIEMRLV
     PMDEEHMSIN VDKVLDYVDD YTIGVVGILG ITYTGKYDDI KALDKKLEEY NKTAKLTVPM
     HIDAASGGMF APFIEPELEW DFRLKNVVSI STSGHKYGLV YPGIGWVLWR DKEYLPQELV
     FDVSYLGGKI PTMAINFSRS ASQIIGQYYN FLRYGFEGYR QIHQRTKDVA MFLASELEKT
     GLFQIYNNGE NLPIVCYKLR DDVNVDWTLY DLADRLLMKG WQVPAYPLPA DLQDTIIQRI
     VCRADLSHNL AELYLRDLKA AIEDLNNARV LNQKSKTGVQ GFTH
//
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