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Database: UniProt/TrEMBL
Entry: A0A0H3EER2_ECO8N
LinkDB: A0A0H3EER2_ECO8N
Original site: A0A0H3EER2_ECO8N 
ID   A0A0H3EER2_ECO8N        Unreviewed;       346 AA.
AC   A0A0H3EER2;
DT   16-SEP-2015, integrated into UniProtKB/TrEMBL.
DT   16-SEP-2015, sequence version 1.
DT   28-FEB-2018, entry version 13.
DE   RecName: Full=Aldose 1-epimerase {ECO:0000256|PIRNR:PIRNR005096};
DE            EC=5.1.3.3 {ECO:0000256|PIRNR:PIRNR005096};
DE   AltName: Full=Galactose mutarotase {ECO:0000256|PIRNR:PIRNR005096};
GN   Name=galM {ECO:0000313|EMBL:ADR26100.1};
GN   OrderedLocusNames=NRG857_03345 {ECO:0000313|EMBL:ADR26100.1};
OS   Escherichia coli O83:H1 (strain NRG 857C / AIEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=685038 {ECO:0000313|EMBL:ADR26100.1, ECO:0000313|Proteomes:UP000008614};
RN   [1] {ECO:0000313|EMBL:ADR26100.1, ECO:0000313|Proteomes:UP000008614}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRG 857C / AIEC {ECO:0000313|Proteomes:UP000008614};
RX   PubMed=21108814; DOI=10.1186/1471-2164-11-667;
RA   Nash J.H., Villegas A., Kropinski A.M., Aguilar-Valenzuela R.,
RA   Konczy P., Mascarenhas M., Ziebell K., Torres A.G., Karmali M.A.,
RA   Coombes B.K.;
RT   "Genome sequence of adherent-invasive Escherichia coli and comparative
RT   genomic analysis with other E. coli pathotypes.";
RL   BMC Genomics 11:667-667(2010).
CC   -!- FUNCTION: Converts alpha-aldose to the beta-anomer.
CC       {ECO:0000256|PIRNR:PIRNR005096}.
CC   -!- CATALYTIC ACTIVITY: Alpha-D-glucose = beta-D-glucose.
CC       {ECO:0000256|PIRNR:PIRNR005096}.
CC   -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC       {ECO:0000256|PIRNR:PIRNR005096}.
CC   -!- SIMILARITY: Belongs to the aldose epimerase family.
CC       {ECO:0000256|PIRNR:PIRNR005096}.
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DR   EMBL; CP001855; ADR26100.1; -; Genomic_DNA.
DR   RefSeq; WP_000931396.1; NC_017634.1.
DR   RefSeq; YP_006119034.1; NC_017634.1.
DR   ProteinModelPortal; A0A0H3EER2; -.
DR   EnsemblBacteria; ADR26100; ADR26100; NRG857_03345.
DR   GeneID; 12877084; -.
DR   KEGG; eln:NRG857_03345; -.
DR   PATRIC; fig|685038.3.peg.678; -.
DR   KO; K01785; -.
DR   OMA; ATWLSCK; -.
DR   BioCyc; ECOL685038:G1GQC-689-MONOMER; -.
DR   UniPathway; UPA00242; -.
DR   Proteomes; UP000008614; Chromosome.
DR   GO; GO:0004034; F:aldose 1-epimerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:InterPro.
DR   Gene3D; 2.70.98.10; -; 1.
DR   InterPro; IPR018052; Ald1_epimerase_CS.
DR   InterPro; IPR013458; Ald_epimerase_bac.
DR   InterPro; IPR015443; Aldose_1-epimerase.
DR   InterPro; IPR008183; Aldose_1/G6P_1-epimerase.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR014718; GH-type_carb-bd.
DR   Pfam; PF01263; Aldose_epim; 1.
DR   PIRSF; PIRSF005096; GALM; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
DR   TIGRFAMs; TIGR02636; galM_Leloir; 1.
DR   PROSITE; PS00545; ALDOSE_1_EPIMERASE; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|PIRNR:PIRNR005096};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008614};
KW   Isomerase {ECO:0000256|PIRNR:PIRNR005096,
KW   ECO:0000313|EMBL:ADR26100.1}.
FT   ACT_SITE    175    175       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR005096-1}.
FT   ACT_SITE    309    309       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR005096-1}.
FT   BINDING     245    245       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR005096-2}.
SQ   SEQUENCE   346 AA;  38231 MW;  EF527FDAA3B9F57D CRC64;
     MLNETPALAP DGQPYRLLTL RNNAGMVVTL MDWGATLLSA RIPLSDGSVR EALLGCASPE
     CYQDQAAFLG ASIGRYANRI ANSRYTFDGE TVTLSPSQGV NQLHGGPEGF DKRRWQIVNQ
     NDRQVLFALS SDDGDQGFPG NLGATVQYRL TDDNRISITY RATVDKPCPV NMTNHVYFNL
     DGEQSDVRNH KLQILAEEYL PVDEGGIPHD GLKSVAGTSF DFRNAKIIAS EFLADDDQRK
     VKGYDHAFLL QAKGDGKKVA AHVWSADEKL QLKVYTTAPA LQFYSGNFLG GTPSRGTEPY
     ADWQGLALES EFLPDSPNHP EWPQPDCFLR PGEEYSSLTE YQFIAQ
//
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