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Database: UniProt/TrEMBL
Entry: A0A0N6ZHQ2_9ACTN
LinkDB: A0A0N6ZHQ2_9ACTN
Original site: A0A0N6ZHQ2_9ACTN 
ID   A0A0N6ZHQ2_9ACTN        Unreviewed;      1271 AA.
AC   A0A0N6ZHQ2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   28-MAR-2018, entry version 12.
DE   SubName: Full=Alpha-ketoglutarate decarboxylase {ECO:0000313|EMBL:AIV34252.1};
DE            EC=4.1.1.71 {ECO:0000313|EMBL:AIV34252.1};
GN   Name=kgd {ECO:0000313|EMBL:AIV34252.1};
GN   ORFNames=NI25_12770 {ECO:0000313|EMBL:AIV34252.1};
OS   Streptomyces sp. CCM_MD2014.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1561022 {ECO:0000313|EMBL:AIV34252.1};
RN   [1] {ECO:0000313|Proteomes:UP000069932}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCM_MD2014 {ECO:0000313|Proteomes:UP000069932};
RA   Mariita R.M., Bhatgnagar S., Hanselmann K., Hossain M.J., Dawson S.C.,
RA   Korlach J., Boitano M., Liles M.R., Moss A.G., Leadbetter J.R.,
RA   Newman D.K.;
RT   "Isolation and characterization of species affiliated with family
RT   Actinomycetaceae.";
RL   Submitted (OCT-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP009754; AIV34252.1; -; Genomic_DNA.
DR   RefSeq; WP_061442577.1; NZ_CP009754.1.
DR   EnsemblBacteria; AIV34252; AIV34252; NI25_12770.
DR   KEGG; strd:NI25_12770; -.
DR   PATRIC; fig|1561022.5.peg.2706; -.
DR   KO; K00164; -.
DR   Proteomes; UP000069932; Chromosome.
DR   GO; GO:0008683; F:2-oxoglutarate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0016746; F:transferase activity, transferring acyl groups; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   Gene3D; 3.30.559.10; -; 1.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   PANTHER; PTHR23152; PTHR23152; 1.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; SSF52518; 2.
DR   TIGRFAMs; TIGR00239; 2oxo_dh_E1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000069932};
KW   Lyase {ECO:0000313|EMBL:AIV34252.1}.
FT   DOMAIN      923   1116       Transket_pyr. {ECO:0000259|SMART:
FT                                SM00861}.
FT   COILED      834    854       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1271 AA;  139123 MW;  1D8A48CEC847917C CRC64;
     MSPQSPSNSS ISTDTDQAGT AGKNPAAAFG ANEWLVDEIY QQYLQDPNSV DRAWWDFFAD
     YKPGAAAQPA SGAVTTDSGS TPQAAPAPQA QASAPAQPKA AAPAPAKPAA QPAAAPAAPA
     AKPAAAPAKP AAKPQAKAAA PAKDADAAAE GPELVTLRGP AAAVAKNMNA SLELPTATSV
     RAVPVKLLFD NRIVINNHLK RARGGKISFT HLIGYAMVQA IKAMPSMNHS FGEKDGKPTL
     VKPAHINLGL AIDLVKPNGD RQLVVAAIKK AETLNFFEFW QAYEDIVRRA RDNKLTMDDF
     TGVTVSLTNP GGLGTVHSVP RLMPGQSVIL GVGSMDYPAE FQGTSQDTLN KLGISKVMTL
     TSTYDHRVIQ GAASGEFLRQ VANLLLGENG FYDDIFKALR IPYEPVRWLK DIDASHDDDV
     TKAARVFELI HSYRVRGHVM ADTDPLEYQQ RKHPDLDITE HGLTLWDLER EFAVGGFAGK
     SLMKLRDILG VLRDSYCRTT GVEFMHIQDP KQRKWIQDRI ERSHTKPERE EQLRILRRLN
     AAEAFETFLQ TKYVGQKRFS LEGGESVIPL LDAVIDSAAE SRLDEVVIGM AHRGRLNVLA
     NVVGKSYAQI FREFEGNLDP KSMHGSGDVK YHLGAEGTFT GLDGEQIKVS LVANPSHLEA
     VDPVLEGVAR AKQDIINKGG TDFTVLPVAI HGDAAFAGQG VVAETLNMSQ LRGYRTGGTV
     HVVINNQVGF TAAPESSRSS MYATDVARMI EAPIFHVNGD DPEAVVRVAR LAFEFRQAFN
     KDVVIDLICY RRRGHNESDN PAFTQPLMYD LIDKKRSVRK LYTESLIGRG DITLEEAEQA
     LQDYQGQLEK VFTEVREAVS QPSAAEPSDP QAEFPVAVNT AVSAETVKRI AESQVNIPDH
     VTIHPRLLPQ LQRRAAMVED GTIDWGMGET LAVGSLLLEG VPVRLSGQDS QRGTFGQRHA
     VVIDRETGDE FTPLLYLSED QARYNVYNSL LSEYAVMGFE YGYSLARPDA LVMWEAQFGD
     FVNGAQTVVD EFISSAEQKW NQTSGVTLLL PHGYEGQGPD HSSARIERFL QLCAQNNMTV
     AMPTLPSNYF HLLRWQVHNP HHKPLVVFTP KSMLRLKAAS SKAEEFTTGQ FRPVIGDDSV
     DPAAVKKVVF TAGKVYYDLD AERKKRGVTD TAIIRIERLY PLPGAELQAE IAKYPNAEKY
     LWAQEEPANQ GAWPFIALNL IDHLDLAVGA DVPHGERLRR ISRPHGSSPA VGSAKRHQAE
     QEQLVREVFE A
//
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