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Database: UniProt/TrEMBL
Entry: A0A0Q3KWA2_BRADI
LinkDB: A0A0Q3KWA2_BRADI
Original site: A0A0Q3KWA2_BRADI 
ID   A0A0Q3KWA2_BRADI        Unreviewed;      1239 AA.
AC   A0A0Q3KWA2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   28-MAR-2018, entry version 15.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=BRADI_5g20927v3 {ECO:0000313|EMBL:KQJ84445.1};
OS   Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Brachypodieae; Brachypodium.
OX   NCBI_TaxID=15368 {ECO:0000313|EMBL:KQJ84445.1};
RN   [1] {ECO:0000313|EMBL:KQJ84445.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bd21 {ECO:0000313|EMBL:KQJ84445.1};
RX   PubMed=20148030; DOI=10.1038/nature08747;
RG   International Brachypodium Initiative;
RT   "Genome sequencing and analysis of the model grass Brachypodium
RT   distachyon.";
RL   Nature 463:763-768(2010).
RN   [2] {ECO:0000313|EMBL:KQJ84445.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bd21 {ECO:0000313|EMBL:KQJ84445.1};
RG   The International Brachypodium Initiative;
RA   Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA   Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA   Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT   "WGS assembly of Brachypodium distachyon.";
RL   Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; CM000884; KQJ84445.1; -; Genomic_DNA.
DR   RefSeq; XP_010240377.1; XM_010242075.2.
DR   GeneID; 100844955; -.
DR   KEGG; bdi:100844955; -.
DR   KO; K10777; -.
DR   ExpressionAtlas; A0A0Q3KWA2; baseline.
DR   GO; GO:0048046; C:apoplast; IEA:EnsemblPlants.
DR   GO; GO:0009506; C:plasmodesma; IEA:EnsemblPlants.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:EnsemblPlants.
DR   GO; GO:0010165; P:response to X-ray; IEA:EnsemblPlants.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR021536; DNA_ligase_IV_dom.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   Pfam; PF11411; DNA_ligase_IV; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617}.
FT   DOMAIN      332    481       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      653    741       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      800    910       BRCT. {ECO:0000259|PROSITE:PS50172}.
SQ   SEQUENCE   1239 AA;  139675 MW;  D8ADF762ABE4D74A CRC64;
     MAATVRFGLL VAMFQAMSRD RTSAKKRGRL RAFLDRAYGA PGRDDYFSAL RLVLPSLDRE
     RGSYGLKEAA LAAALVDALG IAKDSPDAVR LTNWRRGGGG SGRNAGNFSL VAAEVLQRRQ
     GMTSGGLTIK EVNDALDHLS ATENRSEKAL VLSSLIKKTN ALEMKWLLMI ILKDLKLGIS
     EKSIFHEFHP DAEDLFNVTC DLKLVCEKLN DRSQRHKRQD IEVGKAVRPQ LAMRVSNASS
     AWKKLHGKPV VAECKFDGDR IQIHKNGEEI HFFSRTFLDH SEYEPGMSRY IKENILVDRC
     ILDGEMLVWD TALNRFAEFG SNQEIAKAAR DGLETDRQLC YVAFDILYAG DTSVIHQSLT
     ERHEILRKVV KPLKGHLEIL VPTGGLNVHR PSDEPCWSIF AHNIEDAEKF FKETVDNREE
     GIVLKDLDSK WEPGDRSGKW LKLKPDYIHA GTDLDVIIVG GYYGSGRRGG EVAQFLVGLA
     VPSNDNSYPK RFLSFCRVGT GLSDEELDAL VTKLKPHFRK NEYPKKPPRF YEVTNNSKER
     PDVWIESPDK SVIISVTSDI RTIKSEVFAA PYCLRFPRIQ QVRYDKPWHE CLDVQSFVEI
     VHSSNGTMQK AEDDKSLKND NVKHTRTNKR GEKKNVSIIP SHLMKTDISG LKGETLIFAN
     TMFYFVNTPP SYNLEYFHKV VVENGGSFSM NLNDSVTHCI AAEKKGIKYQ AAIRHGRIIH
     YSWILECCKQ KCLLRLQPKY ILFLADFARH KFLEEIDSYA DFYYWDIDVA DLKQIFSNMN
     TITVDQSIVQ RYKKKHCADE RFCFFQGCCV YLHHAPLVNE DYNVISDLAL KRVKHDLTMH
     GGQVCSSLAP ATHLVIVSVL QAYNFDISYK SFSPAERRYL HDKRLHVVSN KWLEDSVDKQ
     MKLPEALYNL KPDTLEEIHI ERSEVDVQPS NDKHEEDEEV EISHVTNARK RGRPSSSSSR
     TVRAAPRPVR RTRARRGNQR AKIGDVESEE SGPGETGQDD QKLKADYTSK MEEDNSDKDQ
     RPPQAAPRPA RRTSARRGNQ LAKIDYLESE ENDHGETGKA DYTTKMEEDN LDKDQGPPPG
     AQFITLEEQE PNGVKLSTGE DTTSSPRYKS KETSGRTNVA ETTSTTGEKI EQMFDPVHAM
     LLNMMPSLRQ ERRQDAITDP PATKLENNPP ARAGSSTSSY RVPVPETVGS ASNSGISASQ
     TGSSTYSAGV PASDPNAAAP PKKKKVSYKD MANDLLKDW
//
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