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Database: UniProt/TrEMBL
Entry: A0A120I150_9MICO
LinkDB: A0A120I150_9MICO
Original site: A0A120I150_9MICO 
ID   A0A120I150_9MICO        Unreviewed;       736 AA.
AC   A0A120I150;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   23-MAY-2018, entry version 11.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:AMB58878.1};
GN   ORFNames=AWU67_08355 {ECO:0000313|EMBL:AMB58878.1};
OS   Microterricola viridarii.
OC   Bacteria; Actinobacteria; Micrococcales; Microbacteriaceae;
OC   Microterricola.
OX   NCBI_TaxID=412690 {ECO:0000313|EMBL:AMB58878.1, ECO:0000313|Proteomes:UP000058305};
RN   [1] {ECO:0000313|Proteomes:UP000058305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ERGS5:02 {ECO:0000313|Proteomes:UP000058305};
RA   Kumar R., Singh D., Swarnkar M.K.;
RT   "First complete genome sequence of a species in the genus
RT   Microterricola, an extremophilic cold active enzyme producing strain
RT   ERGS5:02 isolated from Sikkim Himalaya.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP014145; AMB58878.1; -; Genomic_DNA.
DR   RefSeq; WP_067227825.1; NZ_CP014145.1.
DR   EnsemblBacteria; AMB58878; AMB58878; AWU67_08355.
DR   KEGG; mvd:AWU67_08355; -.
DR   KO; K00031; -.
DR   Proteomes; UP000058305; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000058305};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000058305}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       346    346       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       544    544       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     543    543       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        416    416       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   736 AA;  78954 MW;  F203CECA58B27341 CRC64;
     MTKIVYTYTD EAPMLATHSF FPVISAFAGT AGVELETRDI SLAGRILAAF PEKLSAEQQV
     GDALAELGAL ATTPEANIIK LPNISASLPQ LKAAISELQA KGYDIPDHPD APATDADKDV
     RARYDKIKGS AVNPVLREGN SDRRAPLSVK EYVRKNPHRM GAWAADSKTN VATMGHDDFF
     SNEKSVVIAD DDVLRIEHVN AAGEVTTLHP GVKVLPGEVI DATFLNVAKL HEFLAEAIER
     ARAEDVLFSV HLKATMMKVS DPIIFGHVVR AFFPAVFEQY GAELQAAGLT PNNGLGSILD
     GLDALENGAE IRAAFEQGLK DGPRLAMVNS DKGITNLHVP SDVIVDASMP AMIRSSGHMW
     GVDGAEHDTI AVIPDSSYAG IYQAVIDDCR ANGAYDPTTM GTVPNVGLMA QKAEEYGSHD
     KTFELSEAGT VRVVNQAGEA LLEHAVQAGD IWRACQTKDV AIRDWVKLAV NRARATGTPT
     VFWLDENRAH DANLIAKVNA YLPEHDTAGL DIRVLAPAAA TTLSVERIRR GEDTISVTGN
     VLRDYNTDLF PILELGTSAK MLSIVPLLNG GGLFETGAGG SAPKHVQQLV EENYLRWDSL
     GEFLALAASF EHFADANDNA KARVLGATLD RATGTFLLEN KSPGRALGTI DNRGSHFFLT
     LFWAEELAKQ TEDAELAAAF APLAATLRAN EQTIVDELIA VQGSPVDIGG YFKVDEAKTD
     AVMRPSTTFA EALASL
//
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