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Database: UniProt/TrEMBL
Entry: A0A151NXE1_ALLMI
LinkDB: A0A151NXE1_ALLMI
Original site: A0A151NXE1_ALLMI 
ID   A0A151NXE1_ALLMI        Unreviewed;       857 AA.
AC   A0A151NXE1;
DT   08-JUN-2016, integrated into UniProtKB/TrEMBL.
DT   08-JUN-2016, sequence version 1.
DT   28-FEB-2018, entry version 12.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903};
DE            EC=2.1.1.43 {ECO:0000256|PROSITE-ProRule:PRU00903};
GN   Name=KMT5B {ECO:0000313|EMBL:KYO41561.1};
GN   ORFNames=Y1Q_0006332 {ECO:0000313|EMBL:KYO41561.1};
OS   Alligator mississippiensis (American alligator).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC   Alligator.
OX   NCBI_TaxID=8496 {ECO:0000313|EMBL:KYO41561.1};
RN   [1] {ECO:0000313|EMBL:KYO41561.1, ECO:0000313|Proteomes:UP000050525}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KSC_2009_1 {ECO:0000313|EMBL:KYO41561.1};
RX   PubMed=22293439; DOI=10.1186/gb-2012-13-1-415;
RA   St John J.A., Braun E.L., Isberg S.R., Miles L.G., Chong A.Y.,
RA   Gongora J., Dalzell P., Moran C., Bed'hom B., Abzhanov A.,
RA   Burgess S.C., Cooksey A.M., Castoe T.A., Crawford N.G., Densmore L.D.,
RA   Drew J.C., Edwards S.V., Faircloth B.C., Fujita M.K., Greenwold M.J.,
RA   Hoffmann F.G., Howard J.M., Iguchi T., Janes D.E., Khan S.Y.,
RA   Kohno S., de Koning A.J., Lance S.L., McCarthy F.M., McCormack J.E.,
RA   Merchant M.E., Peterson D.G., Pollock D.D., Pourmand N., Raney B.J.,
RA   Roessler K.A., Sanford J.R., Sawyer R.H., Schmidt C.J., Triplett E.W.,
RA   Tuberville T.D., Venegas-Anaya M., Howard J.T., Jarvis E.D.,
RA   Guillette L.J.Jr., Glenn T.C., Green R.E., Ray D.A.;
RT   "Sequencing three crocodilian genomes to illuminate the evolution of
RT   archosaurs and amniotes.";
RL   Genome Biol. 13:415-415(2012).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|PROSITE-ProRule:PRU00903}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000256|PROSITE-
CC       ProRule:PRU00903}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KYO41561.1}.
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DR   EMBL; AKHW03001628; KYO41561.1; -; Genomic_DNA.
DR   RefSeq; XP_006261296.1; XM_006261234.3.
DR   RefSeq; XP_014459736.1; XM_014604250.2.
DR   GeneID; 102568601; -.
DR   KEGG; amj:102568601; -.
DR   CTD; 51111; -.
DR   KO; K11429; -.
DR   Proteomes; UP000050525; Unassembled WGS sequence.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:UniProtKB-UniRule.
DR   GO; GO:0034773; P:histone H4-K20 trimethylation; IEA:UniProtKB-UniRule.
DR   InterPro; IPR025790; Hist-Lys_N-MTase_Suvar4-20.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR   PROSITE; PS50280; SET; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000050525};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903,
KW   ECO:0000313|EMBL:KYO41561.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050525};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00903};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00903,
KW   ECO:0000313|EMBL:KYO41561.1}.
FT   DOMAIN      170    285       SET. {ECO:0000259|PROSITE:PS50280}.
SQ   SEQUENCE   857 AA;  96626 MW;  197948E93C64D2C6 CRC64;
     MKWLGESKNM VVNGRRSGGK LSNEHLQNQS KLQHTGKENP KTGKNVVERR SSRCSGASGF
     EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM NTRFRPIKGR QEELKEVIER
     FKKDEHLEKA FKSLTSGDWA RHYFLNKNKM QERLFKEHVF IYLRMFATDS GFEILPCNRY
     SSEQNGAKIV ATKEWKRNDK IELLVGCIAE LSEMEENMLL RHGENDFSVM YSTRKNCAQL
     WLGPAAFINH DCRPNCKFVS TGRDTACVKA LRDIEPGEEI SCYYGDGFFG ENNEYCECYT
     CERRGTGAFK SRVGLPAPTP VINSKYGLRE TDKRLNRLKK LGDSSKNSDS QSVGSNTDAD
     TTQEKANATN RKSSIGIKKN SKSRALTRQS MSRIPASSNS TSSKLTHINN SRVPKRLKKP
     AKPLLSKIKL RNQCKRPEQK NASRKLEMGN LVLKEPKVVL YKNLPIRKDK ETEGPVKVAV
     SSGCLTRHAA REYKLNSVKG AHEHGEISPC TYITRRSMRT RMNLKETSDL QLEPNMLDGY
     KNNLTGTQSD SLEQQSHIIH ENDLAHGTSH KGEGRCQKTD VGISKKKSRQ GKLMKSSTKI
     EETDLTYSTP GKDEVLDLIS SHPEPGERSN VVDMPVGYKD CISGSGGCSV TSDNFKTKDG
     FRTAKSKKKR RITRYDAQLI LENSSGIPKL TLRRRHDSSS KANDQENDGM NSSKISIKLS
     KDHEKDNNLY VAKLNNGFNS GSGNSSTKLK IQLKREDENR GAYSEDLHEN GMCCSDTLSL
     LGSRMEVDDY GQYEEETADE SSSEEDDEDE DDYDDEFEDD FIPLPPAKRL RLIVGKDSID
     IDISSRRRED QSLRLNA
//
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