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Database: UniProt/TrEMBL
Entry: A0A1L7CE75_9CORY
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ID   A0A1L7CE75_9CORY        Unreviewed;       738 AA.
AC   A0A1L7CE75;
DT   15-MAR-2017, integrated into UniProtKB/TrEMBL.
DT   15-MAR-2017, sequence version 1.
DT   31-JAN-2018, entry version 6.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:APT84128.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:APT84128.1};
GN   ORFNames=CAQU_02520 {ECO:0000313|EMBL:APT84128.1};
OS   Corynebacterium aquilae DSM 44791.
OC   Bacteria; Actinobacteria; Corynebacteriales; Corynebacteriaceae;
OC   Corynebacterium.
OX   NCBI_TaxID=1431546 {ECO:0000313|EMBL:APT84128.1, ECO:0000313|Proteomes:UP000185478};
RN   [1] {ECO:0000313|EMBL:APT84128.1, ECO:0000313|Proteomes:UP000185478}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S-613 {ECO:0000313|EMBL:APT84128.1,
RC   ECO:0000313|Proteomes:UP000185478};
RA   Ruckert C., Albersmeier A., Winkler A., Kalinowski J.;
RT   "Complete genome sequence of Corynebacterium aquilae S-613T(T) (=DSM
RT   44791(T)), isolated from the choana of a healthy golden eagle.";
RL   Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; CP009245; APT84128.1; -; Genomic_DNA.
DR   RefSeq; WP_075724907.1; NZ_CP009245.1.
DR   KEGG; caqu:CAQU_02520; -.
DR   KO; K00031; -.
DR   Proteomes; UP000185478; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000185478};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:APT84128.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000185478}.
FT   REGION      130    137       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       346    346       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       544    544       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       548    548       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     143    143       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     543    543       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        253    253       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        416    416       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   738 AA;  79657 MW;  2B10584061FD32D5 CRC64;
     MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIDVETRDI SLAGRILSQF PDYLGEDQKV
     ADALAELGEL AKTPEANIIK LPNISASVPQ LKAAIAELQG QGFALPDYPD NPSTDEEKDV
     RARYDSVKGS AVNPVLREGN SDRRAPIAVK NFAKAHPHRM GAWSKDSKTN VATMADNDFR
     HNEQSVIMPA DDTLTITLVG NDGSETVLKD GLKVLAGEVV DSTVMRAAAL DEFLAEQVKR
     AKDEGVLFST HLKATMMKVS DPIIFGHVVR AFFADVYAQY GEQLLAAGLD GENGLAAVYA
     GLDKLDNGAE IKAAFDKALE QGPAVAMVNS DKGITNLHVP SDVIVDASMP AMIRTSGHMW
     NAAGEEQDTL AVLPDSSYAG VYQTVIEDCR ANGAYDPATM GTVPNVGLMA QKAEEYGSHD
     KTFKIPADGT VKVTNAAGET LMEHTVATGD IWRACQAKDA PIRDWVKLAV TRARLSGMPA
     VFWLDPERAH DRNLITLVEK YLPEHDTEGL DIRIMSPVEA TQFSIDRIRK GEDTISVTGN
     VLRDYLTDLF PILELGTSAK MLSVVPLMAG GGLFETGAGG SAPKHVQQLV EENHLRWDSL
     GEFLALGESL RHFGNTDGNT KAAVLADALD KATERLLNDG KSPSRKVGEI DNRGSHFYLT
     TYWADELAKQ TDDAELAEIF APVAKELSDN ADAIAAELLE VQGKAIDLEG YYNPNDAKAT
     AAMRPSEKFN SIIDGLKK
//
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