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Database: UniProt/TrEMBL
Entry: A0A1S3BQX9_CUCME
LinkDB: A0A1S3BQX9_CUCME
Original site: A0A1S3BQX9_CUCME 
ID   A0A1S3BQX9_CUCME        Unreviewed;      1214 AA.
AC   A0A1S3BQX9;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   18-JUL-2018, entry version 8.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   Name=LOC103492544 {ECO:0000313|RefSeq:XP_008451168.1};
OS   Cucumis melo (Muskmelon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; fabids; Cucurbitales; Cucurbitaceae;
OC   Benincaseae; Cucumis.
OX   NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008451168.1};
RN   [1] {ECO:0000313|Proteomes:UP000089565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX   PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA   Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA   Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA   Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA   Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA   Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA   Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B.,
RA   Gabaldon T., Roma G., Guigo R., Casacuberta J.M., Arus P.,
RA   Puigdomenech P.;
RT   "The genome of melon (Cucumis melo L.).";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN   [2] {ECO:0000313|RefSeq:XP_008451168.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   RefSeq; XP_008451168.1; XM_008452946.1.
DR   GeneID; 103492544; -.
DR   KEGG; cmo:103492544; -.
DR   KO; K10777; -.
DR   Proteomes; UP000089565; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 1.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000089565};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617,
KW   ECO:0000313|RefSeq:XP_008451168.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000089565}.
FT   DOMAIN      329    476       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      649    738       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      800    908       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED     1061   1081       {ECO:0000256|SAM:Coils}.
FT   COILED     1093   1113       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1214 AA;  137087 MW;  B79A38568D7F3DBC CRC64;
     MSEPIKFAVL SSLFDWIQRS KSSAKKRSKF RKFLDTFCSP SHYFSAIRLI LPSLDRERGT
     YGLKESVLAT CLIDALGMSR DSDDALRLIN WRKGGAKTGA NAGNFALVAA EVLQRRQGMT
     PGGLTINELN DLLDRLASGE NRAEKTAVLS TLIQKTNAQE MKWIVMIILK DLKLGVSEKS
     IFHEFHPDAE DLFNVTCDLK LVCEKLRDRR QRHKRQDIEV GKAVRPQLAS RVSNANAAWK
     KLHGKEVVAE CKFDGDRIQI HKNGTEVHYF SRNFLDHSEY GHGMSDVIVQ NVLSTRCILD
     GEMLVWDKSL NRFAEFGSNQ EIARAAKDGF DSNRQLCYVA FDVLYVGDTS VIHRSLKERH
     ELLRNVVKPV KGQLEVLVPN DGLNSDCAGC PWSIRAYNVD DVERFFKSTI ENRDEGIVIK
     DLGSKWEPGD RSGKWLKLKP DYVRAGSDLD ALIIGGYYGS GRRGGEVAQF LMGLAERPPS
     NAYPRRFVSF CRVGTGLTDE ELDAVVNKLK PYFRKSEYPR KTAPSFYQVT NNSKERPDVW
     IESPEKSIIL SITSDIRTIK SEVFAAPYSL RFPRIDRVRY DKPWHECLDV QSFVELVHST
     NGTTQRGTNN SGRQDSKGKY IKSIGKGRKK SVSVVPSHLL QTDITGITED SLIFSNMLFY
     IVNVPPTHSL DSLHKLIVEN GGTFSMNLNN SVTHSVAADS KAGIKYEAAK RHGDVIHYSW
     VLECCSQKKL LPLKPKHFLF LSDNSKKKLE EEIDEFADSY FWDLELSELK QLLSNVSISE
     DVKAIDYYRG KYCPKHDWCM FVGCQIYFLP LRLSLKSDWG ILLELSIRRL KVEVSFRGGK
     VSDDPVSATH IVVFEIPGAP VRYETVLKSW NEAEKHAMLK DRIHIVAHQW LEDCLERAQR
     LQEDSYNLNP NGKKSIENIN SGMDSETPLV SEDKDNPQIP CPSMEYKDRG RNEAASGQQM
     LSHSIERSGG KKRGKPATRS MQKAKSGVEQ VRRAQTRKAK GPAKISEVES DSSDNTDEKT
     KAETGNIGTL CTENSEKHVF KTLENEISNS KKRGRPTAGN AQREKAEAEK IRRTRARIAK
     RSAKIGGSES GNNDSADEET NEEESKREKE ENEKTNEFKM LEDYDSKQKG KAIEEVRADF
     KFVEKPEKLE VMKDPLEAML LDMVPSLGMS GTKSSSSSIT TVVEEKKPFV ENKGEAVKKK
     VSYKDVASEL LKDW
//
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