Database: UniProt/TrEMBL
Original site: B2HMN2_MYCMM 
ing and cleavage of host capped pre-mRNAs.
CC       These short capped RNAs are then used as primers for viral mRNAs.
CC       The PB2 subunit is responsible for the binding of the 5' cap of
CC       cellular pre-mRNAs which are subsequently cleaved after 10-13
CC       nucleotides by the PA subunit that carries the endonuclease
CC       activity. {ECO:0000256|HAMAP-Rule:MF_04063,
CC       ECO:0000256|SAAS:SAAS00956500}.
CC       {ECO:0000256|SAAS:SAAS00956481}.
CC   -!- PTM: Phosphorylated on serines and threonines by host kinases,
CC       including human casein kinase II. {ECO:0000256|HAMAP-
CC       Rule:MF_04063}.
CC   -!- SIMILARITY: Belongs to the influenza viruses PA family.
CC       {ECO:0000256|HAMAP-Rule:MF_04063, ECO:0000256|RuleBase:RU361280,
CC       ECO:0000256|SAAS:SAAS00956477}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_04063}.
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DR   EMBL; KJ130195; AHI97755.1; -; Viral_cRNA.
DR   Proteomes; UP000139950; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-UniRule.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0075526; P:cap snatching; IEA:UniProtKB-UniRule.
DR   GO; GO:0039523; P:suppression by virus of host RNA polymerase II activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D;; -; 1.
DR   HAMAP; MF_04063; INFV_PA; 1.
DR   InterPro; IPR037534; INFV_PA.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   3: Inferred from homology;
KW   Cap snatching {ECO:0000256|HAMAP-Rule:MF_04063,
KW   ECO:0000256|SAAS:SAAS00956454};
KW   Complete proteome {ECO:0000313|Proteomes:UP000139950};
KW   Endonuclease {ECO:0000256|HAMAP-Rule:MF_04063,
KW   ECO:0000256|SAAS:SAAS00956462};
KW   Eukaryotic host gene expression shutoff by virus {ECO:0000256|HAMAP-
KW   Rule:MF_04063, ECO:0000256|SAAS:SAAS00956473};
KW   Eukaryotic host transcription shutoff by virus {ECO:0000256|HAMAP-
KW   Rule:MF_04063, ECO:0000256|SAAS:SAAS00956495};
KW   Host cytoplasm {ECO:0000256|HAMAP-Rule:MF_04063,
KW   ECO:0000256|SAAS:SAAS00956464};
KW   Host gene expression shutoff by virus {ECO:0000256|HAMAP-
KW   Rule:MF_04063, ECO:0000256|SAAS:SAAS00956469};
KW   Host nucleus {ECO:0000256|HAMAP-Rule:MF_04063,
KW   ECO:0000256|SAAS:SAAS00956475};
KW   Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04063,
KW   ECO:0000256|SAAS:SAAS00956496};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_04063,
KW   ECO:0000256|SAAS:SAAS00956466};
KW   Inhibition of host RNA polymerase II by virus {ECO:0000256|HAMAP-
KW   Rule:MF_04063, ECO:0000256|SAAS:SAAS00956479};
KW   Manganese {ECO:0000256|HAMAP-Rule:MF_04063,
KW   ECO:0000256|SAAS:SAAS00956501};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_04063,
KW   ECO:0000256|SAAS:SAAS00956498};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_04063,
KW   ECO:0000256|SAAS:SAAS00956446};
KW   Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_04063};
KW   Ribosomal frameshifting {ECO:0000256|SAAS:SAAS00956468}.
FT   MOTIF       184    247       Nuclear localization signal 2 (NLS2).
FT                                {ECO:0000256|HAMAP-Rule:MF_04063}.
FT   METAL        41     41       Manganese 1; via tele nitrogen.
FT                                {ECO:0000256|HAMAP-Rule:MF_04063}.
FT   METAL        80     80       Manganese 2. {ECO:0000256|HAMAP-Rule:
FT                                MF_04063}.
FT   METAL       108    108       Manganese 1. {ECO:0000256|HAMAP-Rule:
FT                                MF_04063}.
FT   METAL       108    108       Manganese 2. {ECO:0000256|HAMAP-Rule:
FT                                MF_04063}.
FT   METAL       119    119       Manganese 1. {ECO:0000256|HAMAP-Rule:
FT                                MF_04063}.
FT   METAL       120    120       Manganese 1; via carbonyl oxygen.
FT                                {ECO:0000256|HAMAP-Rule:MF_04063}.
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