GenomeNet

Database: UniProt/TrEMBL
Entry: B4K5V6_DROMO
LinkDB: B4K5V6_DROMO
Original site: B4K5V6_DROMO 
ID   B4K5V6_DROMO            Unreviewed;       632 AA.
AC   B4K5V6;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   28-FEB-2018, entry version 71.
DE   SubName: Full=Uncharacterized protein, isoform B {ECO:0000313|EMBL:EDW15168.2};
GN   Name=Dmoj\GI24667 {ECO:0000313|EMBL:EDW15168.2};
GN   ORFNames=Dmoj_GI24667 {ECO:0000313|EMBL:EDW15168.2}, GI24667
GN   {ECO:0000313|FlyBase:FBgn0147389};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:EDW15168.2, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:EDW15168.2, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|SAAS:SAAS00563877}.
CC       Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; CH933806; EDW15168.2; -; Genomic_DNA.
DR   RefSeq; XP_001999707.2; XM_001999671.2.
DR   EnsemblMetazoa; FBtr0423565; FBpp0381491; FBgn0147389.
DR   GeneID; 6573641; -.
DR   KEGG; dmo:Dmoj_GI24667; -.
DR   FlyBase; FBgn0147389; Dmoj\GI24667.
DR   InParanoid; B4K5V6; -.
DR   KO; K11419; -.
DR   OrthoDB; EOG091G0624; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   Bgee; FBgn0147389; -.
DR   GO; GO:0000792; C:heterochromatin; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005701; C:polytene chromosome chromocenter; IEA:EnsemblMetazoa.
DR   GO; GO:0046974; F:histone methyltransferase activity (H3-K9 specific); IEA:EnsemblMetazoa.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006306; P:DNA methylation; IEA:EnsemblMetazoa.
DR   GO; GO:0048132; P:female germ-line stem cell asymmetric division; IEA:EnsemblMetazoa.
DR   GO; GO:0031507; P:heterochromatin assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0070868; P:heterochromatin organization involved in chromatin silencing; IEA:EnsemblMetazoa.
DR   GO; GO:2001229; P:negative regulation of response to gamma radiation; IEA:EnsemblMetazoa.
DR   CDD; cd00024; CHROMO; 1.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR023780; Chromo_domain.
DR   InterPro; IPR023779; Chromodomain_CS.
DR   InterPro; IPR011381; Histone_H3-K9_MeTrfase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR007728; Pre-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00385; Chromo; 1.
DR   Pfam; PF05033; Pre-SET; 1.
DR   Pfam; PF00856; SET; 1.
DR   PIRSF; PIRSF009343; SUV39_SET; 1.
DR   SMART; SM00298; CHROMO; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00468; PreSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF54160; SSF54160; 1.
DR   PROSITE; PS00598; CHROMO_1; 1.
DR   PROSITE; PS50013; CHROMO_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50867; PRE_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Chromosome {ECO:0000256|SAAS:SAAS00508265};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009343-2};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533};
KW   Zinc {ECO:0000256|PIRSR:PIRSR009343-2}.
FT   DOMAIN      209    268       Chromo. {ECO:0000259|PROSITE:PS50013}.
FT   DOMAIN      403    471       Pre-SET. {ECO:0000259|PROSITE:PS50867}.
FT   DOMAIN      474    600       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN      616    632       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   COILED       69     89       {ECO:0000256|SAM:Coils}.
FT   METAL       405    405       Zinc 1. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       405    405       Zinc 2. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       407    407       Zinc 1. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       424    424       Zinc 1. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       425    425       Zinc 2. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       453    453       Zinc 2. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       453    453       Zinc 3. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       457    457       Zinc 2. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       459    459       Zinc 3. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       463    463       Zinc 3. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       560    560       Zinc 4. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       620    620       Zinc 4. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       622    622       Zinc 4. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
FT   METAL       627    627       Zinc 4. {ECO:0000256|PIRSR:PIRSR009343-
FT                                2}.
SQ   SEQUENCE   632 AA;  72154 MW;  B4BA1BCEAD865BDD CRC64;
     MATAEAQVNV NTNLQKQDLS NLEISNLTPL SPEVISRQAT INIGTIGHVA HGKSTVVKAI
     SGVQTVRFKN ELERNITIKL ERLSEMKIQK LLKSKQQRDA YDLKQRQQLK QLIKRRRQAS
     KSRQQENVIA PYTRTRRSIS QVSLSPSHSS GYGSVIGPDE HDTLPAAINQ DDNSTVNRRK
     RCRSSNDLQN EHSSSPALKR PKKTPKGEYF VEVIERVEVM HNEPIFYVKW LGYDNSENTW
     ETFENLADCV QLEDFVDRQT QLYEPYIKKI TSKLEAELVT ATPLDLNSIN IEKDLDNYES
     MPLSLDLILL AQYCAAGSRS QRERQRIEER ALRRIQMQRC YYARRKQLQE LALFERRMNS
     VEHPAPPITV KNDVDLDSID ANFVYIQKNI LSDSVPHPEE AVFGCNCKHD EGDGKTECCA
     TSRCCARLAG ELYAYERTTR RLRLPQGSAI FECNSRCSCD DSCTNRLVQF GRKHPLELFK
     TSNGRGWGVR TPNSLRKGEF VCEYVGEIIS SDEANERGKA YDDKGRTYLF DLDYNTAAES
     EFTIDAANYG NVSHFINHSC DPNLAVFPCW IEHLNMALPH LVFFTTRYIK AGEELSFDYI
     RADNEAVPYE NLSTAARVEC RCGAPNCRKV LF
//
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