GenomeNet

Database: UniProt/TrEMBL
Entry: D4A5H6_RAT
LinkDB: D4A5H6_RAT
Original site: D4A5H6_RAT 
ID   D4A5H6_RAT              Unreviewed;      2294 AA.
AC   D4A5H6;
DT   20-APR-2010, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 2.
DT   18-JUL-2018, entry version 76.
DE   SubName: Full=Kinesin family member 9 (Predicted) {ECO:0000313|EMBL:EDL77077.1};
DE   SubName: Full=SET domain-containing 2 {ECO:0000313|Ensembl:ENSRNOP00000028408};
GN   Name=Setd2 {ECO:0000313|Ensembl:ENSRNOP00000028408,
GN   ECO:0000313|RGD:1305576};
GN   Synonyms=Kif9_predicted {ECO:0000313|EMBL:EDL77077.1};
GN   ORFNames=rCG_26017 {ECO:0000313|EMBL:EDL77077.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|Ensembl:ENSRNOP00000028408, ECO:0000313|Proteomes:UP000002494};
RN   [1] {ECO:0000313|Ensembl:ENSRNOP00000028408, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000028408,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T.,
RA   Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A.,
RA   Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M.,
RA   Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K.,
RA   Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S.,
RA   Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J.,
RA   Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y.,
RA   Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A.,
RA   Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J.,
RA   D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R.,
RA   Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A.,
RA   Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E.,
RA   Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E.,
RA   Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D.,
RA   Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M.,
RA   Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O.,
RA   Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O.,
RA   Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H.,
RA   Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S.,
RA   Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J.,
RA   Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E.,
RA   Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F.,
RA   Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K.,
RA   Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S.,
RA   Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M.,
RA   Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M.,
RA   Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A.,
RA   Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S.,
RA   Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G.,
RA   Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H.,
RA   Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R.,
RA   Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M.,
RA   Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H.,
RA   Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S.,
RA   Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into
RT   mammalian evolution.";
RL   Nature 428:493-521(2004).
RN   [2] {ECO:0000313|EMBL:EDL77077.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL77077.1};
RX   PubMed=15632090; DOI=10.1101/gr.2889405;
RA   Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M.,
RA   Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z.,
RA   Istrail S., Li P., Sutton G.;
RT   "Gene and alternative splicing annotation with AIR.";
RL   Genome Res. 15:54-66(2005).
RN   [3] {ECO:0000313|EMBL:EDL77077.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN {ECO:0000313|EMBL:EDL77077.1};
RA   Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H.,
RA   Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M.,
RA   Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L.,
RA   Lu F., Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C.,
RA   Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|Ensembl:ENSRNOP00000028408}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000028408};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
RN   [5] {ECO:0000213|PubMed:22673903}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
RA   Lundby C., Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14
RT   different rat organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; AABR07071506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07071507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07071508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07071509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07071510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07071511; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH473954; EDL77077.1; -; Genomic_DNA.
DR   RefSeq; NP_001101659.1; NM_001108189.1.
DR   UniGene; Rn.53471; -.
DR   Ensembl; ENSRNOT00000028409; ENSRNOP00000028408; ENSRNOG00000020915.
DR   GeneID; 316013; -.
DR   KEGG; rno:316013; -.
DR   CTD; 29072; -.
DR   RGD; 1305576; Setd2.
DR   eggNOG; KOG4442; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   GeneTree; ENSGT00780000121845; -.
DR   KO; K11423; -.
DR   Reactome; R-RNO-3214841; PKMTs methylate histone lysines.
DR   Proteomes; UP000002494; Chromosome 8.
DR   Bgee; ENSRNOG00000020915; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 1.10.1740.100; -; 1.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR038190; SRI_sf.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002494};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:D4A5H6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533}.
FT   DOMAIN     1225   1279       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     1281   1398       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     1405   1421       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DOMAIN     2119   2152       WW. {ECO:0000259|PROSITE:PS50020}.
FT   COILED     1852   1872       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2294 AA;  259309 MW;  0544EE34E75BABDC CRC64;
     MKSVPESLEL DMKQDIVSNS LEEHTNQTLK EQADNALQKE DSHIGKEEEV SDGSKISLSS
     KKASSKKKSS QFEGTFLGSE SDEDSVRTSS SQRSHDLKSS TSIEKERDFK KSSAPSKSED
     LGKSSRSKTE RDDKYFSYSK LERDTRYVST RCRSERDRRR SRSRSRSDRV SRTSLSYSRS
     ERSHYYDSER RYHRSSPYRE RTRYSRPYTD NRARESSDSE DEYKKTYPRR TSAHSYRDLR
     TSSSYSKFDR DCKTETSYLE MERRGKYSSK LERESKRTSE HEAIKRCCSP PNELGFRRGS
     SYSKHDNNST SRYKSALSKS ISKSDKFKNS FCCTELNEEN KQSHSFSLQT PCSKGSELRT
     INKIPEREKT GSPSPSNQLN DSPTFKKLDE SPILKPEFIG HDSHESIKEL ELPKMKNDQL
     RNFCSIELNV NGSPETETDV ATFRTSKPDA ISMTSDDSVT GSEVSPLIKG CVLSSNGFQS
     VGRCRERDAD DACRQHNKSK SPFRETEPLL SPHHDKVMSL PVKTIDYSKT LIKEPVDKRH
     SCCKTKDSDR YCSPNESSEA ENREISSNCF VNVHLDSKTV VCDNRELTDQ HSEFTCDGYK
     QSIGSTSSAS LNHFDDLYES VGSSGISSLQ SLPSGIRCEE NTSPALDTVQ SKKGIDFLKY
     VGKETDVVSA LPDSGKAFSS WENRHNMLSG QSLQESQEEG SSTLHERRGR SEVSLDEEEQ
     RGHTHISDDS EVVFPYDLNL TMEDSDGVTY TLKCDSSGNA PEIVSTVHGD YSASSASSSD
     ESDSEDTESD DSSIPRNRLQ SVVVVPKNST LPMEETSPCS SRSSQSYRHY SDHWEDGLES
     RRHAYEEKFE SMASKGCSQT EKFFLHKGTE RNPETSYSQF SRKIDNHLPE IAHSQSDGVD
     STSHTDVKSD SVGHLNSEDA IRAKMSRPQE LPVYCDDFED LPNTSRQQMI FSNRPDSSRL
     GKAELSFSSS CDISRMDGLH SSEELRNLGW DFSQQERPTT TYQQPDSSYG TCGTHKYQQS
     AEHYGGTHDY WQGNGYWDPR SAGRPPGTGV VYDRIQGQVP DSLTDDREEE ENWDQRSGSH
     FSSPSNKFFF HQKDKGSVQA PEISSNSIKD SLVINERKDF SKNFEKNDIK ERGPPKKRRQ
     ELESDSESDG ELQARKKVRV EIEQGQSSVP QHSELVGPSC AMDDFRDPQR WKEFAKLGKM
     PCYFDLIEEN VYLTERKKNK SHRDIKRMQC ECTPLSKDER AQGEVACGED CLNRLLMIEC
     SSRCPNGDYC SNRRFQRKQH ADVEVILTEK KGWGLRAAKD LPSNTFVLEY CGEVLDHKEF
     KARVKEYARN KNIHYYFMAL KNDEIIDATQ KGNCSRFMNH SCEPNCETQK WTVNGQLRVG
     FFTTKLVPSG SELTFDYQFQ RYGKEAQKCF CGSANCRGYL GGENRVSIRA AGGKMKKERS
     RKKDSVDGEL EALMENGEGL SDKNQVLSLS RLMVRIETLE QKLTCLKLIQ NTHSQSCLKS
     FLERHGLSLL WIWMAELGDG RESNQKLQEE IIKTLEHLPI PTKNMLEESK VLPIIQRWSQ
     TKTAVPQLSE GDGYSSENTS RAHTPLNTPD PSAKPSTEVD TDTPKKLIFR RLKIISENSM
     DSAVSDVTSE LECKDGKEDL DQLETVTVEE DEELQSQQLL PSQLCESKVE SESTIDVSKL
     PISEPEADTE TEPKDSNGTK LEETIAEETP SQDEEEGVSD VESERSQEPP DKTVDISDLA
     TKLLDSWKDL KEVYRIPKKS QTEKESTVTE RGRDTAAFRD QTAPKTPNRS REREPDKQSQ
     NKEKRKRRGS LSPPSSAYER GTKRPDDRYD TPTSKKKVRI KDRNKLSTEE RRKLFEQEVA
     QREAQKQQQQ MQNLGMTSPL PFDSLGYNAS HHPFAGYPPG YPMQAYVDPS NPNAGKVLLP
     TPSMDPVCSP APYDHAQPLV GHSTESLAAP PSVPVVPHGA ASVEVSSSQY AAQSESVVHQ
     DSSVPGMPVQ TPGPVQGQNY SVWDSNQQSV SVQPQYSPAQ SQATIYYQGQ TCSTVYGVTS
     PYSQTTPPIV QSYAQPSLQY IQGQQIFTAH PQGVVVQPAA AVTTIVAPGQ PQPLQPPEMV
     VTNNLLDLPP PSPPKPKTIV LPPNWKTARD PEGKIYYYHV ITRQTQWDPP TWESPGDDAS
     LEHEAEMDLG TPTYDENPMK TSKKPKTAEA DTSSELAKKS KEVFRKEMSQ FIVQCLNPYR
     KPDCKVGRIT TTEDFKHLAR KLTHGVMNKE LKYCKNPEDL ECNENVKHKT KEYIKKYMQK
     FGAVYKPKED TELE
//
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