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Database: UniProt/TrEMBL
Entry: E4NAU5_KITSK
LinkDB: E4NAU5_KITSK
Original site: E4NAU5_KITSK 
ID   E4NAU5_KITSK            Unreviewed;       470 AA.
AC   E4NAU5;
DT   08-FEB-2011, integrated into UniProtKB/TrEMBL.
DT   08-FEB-2011, sequence version 1.
DT   20-JUN-2018, entry version 40.
DE   RecName: Full=Glutamate decarboxylase {ECO:0000256|RuleBase:RU361171};
DE            EC=4.1.1.15 {ECO:0000256|RuleBase:RU361171};
GN   OrderedLocusNames=KSE_25120 {ECO:0000313|EMBL:BAJ28326.1};
OS   Kitasatospora setae (strain ATCC 33774 / DSM 43861 / JCM 3304 / KCC
OS   A-0304 / NBRC 14216 / KM-6054) (Streptomyces setae).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Kitasatospora.
OX   NCBI_TaxID=452652 {ECO:0000313|EMBL:BAJ28326.1, ECO:0000313|Proteomes:UP000007076};
RN   [1] {ECO:0000313|EMBL:BAJ28326.1, ECO:0000313|Proteomes:UP000007076}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33774 / DSM 43861 / JCM 3304 / KCC A-0304 / NBRC 14216 /
RC   KM-6054 {ECO:0000313|Proteomes:UP000007076};
RX   PubMed=21059706; DOI=10.1093/dnares/dsq026;
RA   Ichikawa N., Oguchi A., Ikeda H., Ishikawa J., Kitani S., Watanabe Y.,
RA   Nakamura S., Katano Y., Kishi E., Sasagawa M., Ankai A., Fukui S.,
RA   Hashimoto Y., Kamata S., Otoguro M., Tanikawa S., Nihira T.,
RA   Horinouchi S., Ohnishi Y., Hayakawa M., Kuzuyama T., Arisawa A.,
RA   Nomoto F., Miura H., Takahashi Y., Fujita N.;
RT   "Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary
RT   snapshot of the family Streptomycetaceae.";
RL   DNA Res. 17:393-406(2010).
CC   -!- CATALYTIC ACTIVITY: L-glutamate = 4-aminobutanoate + CO(2).
CC       {ECO:0000256|RuleBase:RU361171}.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|PIRSR:PIRSR602129-50,
CC         ECO:0000256|RuleBase:RU361171};
CC   -!- SIMILARITY: Belongs to the group II decarboxylase family.
CC       {ECO:0000256|RuleBase:RU361171}.
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DR   EMBL; AP010968; BAJ28326.1; -; Genomic_DNA.
DR   RefSeq; WP_014135640.1; NC_016109.1.
DR   STRING; 452652.KSE_25120; -.
DR   EnsemblBacteria; BAJ28326; BAJ28326; KSE_25120.
DR   KEGG; ksk:KSE_25120; -.
DR   PATRIC; fig|452652.3.peg.2517; -.
DR   eggNOG; ENOG4105CVK; Bacteria.
DR   eggNOG; COG0076; LUCA.
DR   KO; K01580; -.
DR   OMA; RPNLVMG; -.
DR   OrthoDB; POG091H06F5; -.
DR   BioCyc; KSET452652:G1H62-2539-MONOMER; -.
DR   Proteomes; UP000007076; Chromosome.
DR   GO; GO:0004351; F:glutamate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0006536; P:glutamate metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.640.10; -; 1.
DR   InterPro; IPR010107; Glutamate_decarboxylase.
DR   InterPro; IPR002129; PyrdxlP-dep_de-COase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   PANTHER; PTHR43321; PTHR43321; 1.
DR   Pfam; PF00282; Pyridoxal_deC; 1.
DR   SUPFAM; SSF53383; SSF53383; 1.
DR   TIGRFAMs; TIGR01788; Glu-decarb-GAD; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007076};
KW   Decarboxylase {ECO:0000256|RuleBase:RU361171};
KW   Lyase {ECO:0000256|RuleBase:RU361171, ECO:0000313|EMBL:BAJ28326.1};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR602129-50,
KW   ECO:0000256|RuleBase:RU361171};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007076}.
FT   MOD_RES     283    283       N6-(pyridoxal phosphate)lysine.
FT                                {ECO:0000256|PIRSR:PIRSR602129-50}.
SQ   SEQUENCE   470 AA;  52116 MW;  B6550DCC020918C7 CRC64;
     MALHKGQGRG EDERRLPVSP LHVLTDPLGS MQLAPPLHRL PRVPIPPPVA YQLIHDELML
     DGNARLNLAT FVTTQMDEHA DRLMAECRDK NMIDKDEYPQ TAELERRCVA ILADLWHAPD
     PAAAVGCSTT GSSEACMLAG MALKRRWTAR NADRYAAGAR PNLVMGVNVQ VCWEKFCNFW
     EVEARLVPME GERFHLSAEE AVARCDENTI GVVGILGSTF DGSYEPIAEI CAALDAFQER
     TGLDVPVHVD GASGGMVAPF LDPELKWDFR LPRVASINAS GHKYGLVYPG VGWALWRDGE
     ALPEELVFKV NYLGGEMPTF ALNFSRPGAE VVAQYYAFLR LGFGGYHAIQ QACRDVAEYL
     AAEIAKCGPF RLITKGDQLP VFAFTTVDGC PFDVFDVSRR LRERGWQVPA YTFPEGRTDL
     AVLRVVCRNG FSRDLADLLL ADLRRLLPEL ERQPAPLSEL GMPQRSGFHH
//
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