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Database: UniProt/TrEMBL
Entry: G1SDI9_RABIT
LinkDB: G1SDI9_RABIT
Original site: G1SDI9_RABIT 
ID   G1SDI9_RABIT            Unreviewed;       719 AA.
AC   G1SDI9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   20-JUN-2018, entry version 45.
DE   SubName: Full=Transglutaminase 5 {ECO:0000313|Ensembl:ENSOCUP00000000476};
GN   Name=TGM5 {ECO:0000313|Ensembl:ENSOCUP00000000476};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000000476, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000000476, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000000476}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000000476};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   EMBL; AAGW02024585; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02024586; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02024587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_008267334.1; XM_008269112.2.
DR   STRING; 9986.ENSOCUP00000000476; -.
DR   Ensembl; ENSOCUT00000000551; ENSOCUP00000000476; ENSOCUG00000000551.
DR   GeneID; 100359233; -.
DR   KEGG; ocu:100359233; -.
DR   CTD; 9333; -.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   InParanoid; G1SDI9; -.
DR   KO; K05622; -.
DR   OMA; GVLNGNW; -.
DR   OrthoDB; EOG091G030K; -.
DR   TreeFam; TF324278; -.
DR   Proteomes; UP000001811; Chromosome 17.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT   DOMAIN      270    363       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    278    278       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    337    337       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    360    360       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       400    400       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       402    402       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       448    448       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       453    453       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   719 AA;  79797 MW;  AB8DCC73DE6B016C CRC64;
     MAQGLEVALT DLQSSRNNVR HHTEEIAVDR LLVRRGQAFL ITLYFRNRGF QPGLDNIIFV
     AETGPLPDLA KGTRAVFGLG SRGGPSPWIA LLESNGATSL EVSLCAPPVA AVGRYLLKVH
     IDAFQGSITA YQLGEFILLF NPWCPEDAVY LDSEPQRQEY VVNDYGFIYQ GNKNWIRPCP
     WNYGQFEENI VDICLELLDK SLNFQVDPAT DCALRGSPVY IGRVVCAMIN SNDDNGVLNG
     NWSENYTDGL NPAEWTGSVA ILKQWHATGC QPVRYGQCWV FAAVMCTVMR CLGIPTRVIT
     NFDSGHDTDG NLVIDEYYDS TGRILENKKK DSIWNFHVWN ECWMARRDLP PGYGGWQLLD
     ATPQETSNGL YCCGPASVKA IKEGEVDLKY DTPFAFSMVN ADCVSWLVYG GKEQKLHRNT
     SAVGSFISTK GVQSDERDDV TENYKYQEGS PEERQVFLKA VQKLKAGKSQ GPPGADAPPS
     SSTPLSGDSP QSLDIPSLRP GEVAQVSLKF KLLEPPHMGQ DINFMLLAIN VSPQSKDLKV
     NLSAQSLLHD GSPMPPFWQD TAFLTLFPQE VKTYSCIIPY FQYSQYLSTD KLIRISALSE
     EKNSLEKILV NKIITLAYPG IMINVLGAAI VNQPLSIQVI FSNPLLEQVA NCVLTVEGSG
     LFKKQQRVLI GVLKPQHRAS ITLTTVPFKS GQRQIQANLK SDKFKDIKGY RSVYVDFGL
//
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