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Database: UniProt/TrEMBL
Entry: G1SRI8_RABIT
LinkDB: G1SRI8_RABIT
Original site: G1SRI8_RABIT 
ID   G1SRI8_RABIT            Unreviewed;       921 AA.
AC   G1SRI8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   25-APR-2018, entry version 47.
DE   SubName: Full=Hexokinase 1 {ECO:0000313|Ensembl:ENSOCUP00000005792};
GN   Name=HK1 {ECO:0000313|Ensembl:ENSOCUP00000005792};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005792, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000005792, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000005792}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005792};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; AAGW02036948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02036949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02036950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02036951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_008268244.1; XM_008270022.2.
DR   RefSeq; XP_017204219.1; XM_017348730.1.
DR   STRING; 9986.ENSOCUP00000005792; -.
DR   Ensembl; ENSOCUT00000006701; ENSOCUP00000005792; ENSOCUG00000006697.
DR   GeneID; 100340945; -.
DR   KEGG; ocu:100340945; -.
DR   CTD; 3098; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   GeneTree; ENSGT00390000017159; -.
DR   InParanoid; G1SRI8; -.
DR   KO; K00844; -.
DR   OMA; YDDQQCE; -.
DR   OrthoDB; EOG091G08MD; -.
DR   TreeFam; TF314238; -.
DR   Proteomes; UP000001811; Chromosome 18.
DR   Bgee; ENSOCUG00000006697; -.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0097228; C:sperm principal piece; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004340; F:glucokinase activity; IEA:Ensembl.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0042834; F:peptidoglycan binding; IEA:Ensembl.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   GO; GO:0002741; P:positive regulation of cytokine secretion involved in immune response; IEA:Ensembl.
DR   GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       26    223       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      229    463       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      474    671       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      677    911       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   921 AA;  102799 MW;  CDDB3A15E61F6FE9 CRC64;
     MGQNCQRTQA TEPKMVIQPP LTEKKIDKYL YAMRLSDETL VDIMTRFKKE MKNGLSRDFN
     PTATVKMLPT FVRSIPDGSE KGDFIALDLG GSSFRILRVQ VNHEKKQNVH MESEAYETPE
     NIVHGSGSQL FDHVAECLGD FMEKRNIKDK KLPVGFTFSF PCRQSKIDEA VLITWTKRFK
     ASGVEGADVV KLLNKAIKKR GDYDANIVAV VNDTVGTMMT CGYDDQQCEV GLIIGTGTNA
     CYMEELRHID LVEGDEGRMC INTEWGAFGD DGALEDIRTE FDREIDRGSL NPGKQLFEKM
     VSGMYMGELV RLILVKMAKE GLLFEGRITP ELLTRGKFNT SDVSAIEKNK EGLHNAKEIL
     TRLGVEPSDD DCISVQHVCT IVSFRSANLV AATLGAILNR LRDNKGTPRL RTTVGVDGSL
     YKTHPQYSRR FHKTLRRLVP DSDVRFLLSE SGSGKGAAMV TAVAYRLAEQ HRQIEETLAH
     FRLTKEMLLE VKKRMRTEME AGLRRQTHDK AVVKMLPSFV RSTPDGTENG DFLALDLGGT
     NFRVLLVKIR SGKKRTVEMH NKIYAIPLEI MQGTGEELFD HIVSCISDFL DYMGIKGPRM
     PLGFTFSFPC KQTSLDAGIL VTWTKGFKAT DCVGHDVATL LRDAIKRREE FDLDVVAMVN
     DTVGTMMTCA YEEPTCEVGL IVGTGCNACY MEEMRNVEML EGNEGQMCIN MEWGAFGDNG
     CLDDIRTIYD RLVDEYSLNA GKQRYEKMIS GMYLGEIVRN ILIDFTKKGF LFRGQVSEPL
     KTRGIFETKF LSQIESDRLA LLQVRAILQQ LGLNSTCDDS ILVKTVCGVV SRRAAQLCGA
     GMAAVVDKIR ENRGLDHLNV TVGVDGTLYK LHPHFSRIMH QTVKELSPKC NVSFLLSEDG
     SGKGAALITA VGVRLRGELS S
//
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