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Database: UniProt/TrEMBL
Entry: G2X6D8_VERDV
LinkDB: G2X6D8_VERDV
Original site: G2X6D8_VERDV 
ID   G2X6D8_VERDV            Unreviewed;      1012 AA.
AC   G2X6D8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   23-MAY-2018, entry version 39.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=VDAG_05720 {ECO:0000313|EMBL:EGY14556.1};
OS   Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS   (Verticillium wilt).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Glomerellales;
OC   Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=498257 {ECO:0000313|Proteomes:UP000001611};
RN   [1] {ECO:0000313|Proteomes:UP000001611}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VdLs.17 / ATCC MYA-4575 / FGSC 10137
RC   {ECO:0000313|Proteomes:UP000001611};
RX   PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA   Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA   Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA   Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R.,
RA   Santhanam P., Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z.,
RA   Inderbitzin P., Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R.,
RA   Galagan J., Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT   "Comparative genomics yields insights into niche adaptation of plant
RT   vascular wilt pathogens.";
RL   PLoS Pathog. 7:E1002137-E1002137(2011).
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; DS572705; EGY14556.1; -; Genomic_DNA.
DR   RefSeq; XP_009653412.1; XM_009655117.1.
DR   EnsemblFungi; EGY14556; EGY14556; VDAG_05720.
DR   GeneID; 20707183; -.
DR   KEGG; vda:VDAG_05720; -.
DR   InParanoid; G2X6D8; -.
DR   KO; K10777; -.
DR   OrthoDB; EOG092C18KW; -.
DR   Proteomes; UP000001611; Unassembled WGS sequence.
DR   GO; GO:0032807; C:DNA ligase IV complex; IEA:EnsemblFungi.
DR   GO; GO:0000790; C:nuclear chromatin; IEA:EnsemblFungi.
DR   GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00027; BRCT; 2.
DR   Gene3D; 1.10.3260.10; -; 1.
DR   Gene3D; 3.40.50.10190; -; 2.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR029710; LIG4.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR10459:SF7; PTHR10459:SF7; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SMART; SM00292; BRCT; 2.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF52113; SSF52113; 2.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS50172; BRCT; 2.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001611};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617, ECO:0000313|EMBL:EGY14556.1};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001611}.
FT   DOMAIN      457    582       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
FT   DOMAIN      747    827       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   DOMAIN      911   1012       BRCT. {ECO:0000259|PROSITE:PS50172}.
FT   COILED      703    723       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1012 AA;  115204 MW;  98B8802C66C39E55 CRC64;
     MKKLATILVL SSPKPIPKAS PAVMSHQQGQ PSPSAAAIEE DERQYAVGGM TLQEVNENYP
     GRPRNHSETF LFSELFKSLF NPLMENKKQP PGSGPPRAKL GPHGPSKPSP SEQRRHIIDR
     FISRWRKDVG NDFYPAMRLI LPDKDRDRGV YGLKENAIGK LLVKLMKIDK NSEDGYNLLH
     WKLPGQTTAS RMAGDFAGRA FEVLSKRPMR IEVGDMTIAD VNELLDKLAG SSGELENLEV
     FETFYERMNA EELMWLIRII LKQMKVGATE KTLLHLWHPD AETLFNVSSS LRRVCWELFD
     PQYRLEQENT GVTLMQCFQP QLAQFQMPAS FQKMVDYLRP TEEDPEYWIE EKLDGERMQM
     HMMEDASIPG GKRFCFWSRK AKDYTYLYGE GLKDDRGALT RHLGKAFAAG VRNIILDGEM
     ITWDPETDKI MQFGTLKTAA LAEQKNPYNN TGPRPLFRVF DILYLNDQPL TRYTLRDRYN
     ALSKAVVGVH RRIEVHEHEA ATSADAIEPL LRKVVAEASE GLVLKNPRSM YRLNSRNDDW
     LKVKPEYMTE FGESLDCVVI GGYYGSGKRG GILSTYLCGL RVGENHIKAG ANPEKCFSLF
     KVGGGFSVED YAEIRHHTDG KWKDWDPKKP PNEYIELAHG FAEKPDVWIR PKDSFVLEAK
     ASSVGPSDQF ALGFTLRFPR FRKLRKDKSW DQGLSVQEFQ DLRRRVEEEA QEKTMSVENT
     KRRAVKRVKK ELVIAGTDST PVQFEGEKSK VFEGLEFCVL SESLKPFKKT KTQLETMIKA
     NGGRITQRHA ARSDLILIAD KRVVSVASLI KKGDVDIIRP NWVQDCLAQE TDDGLLPYEE
     RHLFHATEGL REIARQNTDE FGDSYFRIVD VEELRQILGD MPPHEESEGR EEGAAEFARQ
     LKERGNDLGE RDSAIFDRCV VHLHVLPGGE LDAFRLRNYI AFGGGEVTDG LPVDSSTHIV
     LVGGQDAEKQ DAAVSVRKDI GRRRKIPRVV DAQWVEDSWK ERTMLDEERF GV
//
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