GenomeNet

Database: UniProt/TrEMBL
Entry: G3H6T5_CRIGR
LinkDB: G3H6T5_CRIGR
Original site: G3H6T5_CRIGR 
ID   G3H6T5_CRIGR            Unreviewed;       917 AA.
AC   G3H6T5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   20-JUN-2018, entry version 39.
DE   SubName: Full=Hexokinase-1 {ECO:0000313|EMBL:EGV93783.1};
GN   ORFNames=I79_006054 {ECO:0000313|EMBL:EGV93783.1};
OS   Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10029 {ECO:0000313|EMBL:EGV93783.1, ECO:0000313|Proteomes:UP000001075};
RN   [1] {ECO:0000313|Proteomes:UP000001075}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CHO K1 cell line {ECO:0000313|Proteomes:UP000001075};
RX   PubMed=21804562; DOI=10.1038/nbt.1932;
RA   Xu X., Nagarajan H., Lewis N.E., Pan S., Cai Z., Liu X., Chen W.,
RA   Xie M., Wang W., Hammond S., Andersen M.R., Neff N., Passarelli B.,
RA   Koh W., Fan H.C., Wang J., Gui Y., Lee K.H., Betenbaugh M.J.,
RA   Quake S.R., Famili I., Palsson B.O., Wang J.;
RT   "The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell
RT   line.";
RL   Nat. Biotechnol. 29:735-741(2011).
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; JH000180; EGV93783.1; -; Genomic_DNA.
DR   RefSeq; XP_003499940.1; XM_003499892.3.
DR   PRIDE; G3H6T5; -.
DR   GeneID; 100765413; -.
DR   KEGG; cge:100765413; -.
DR   CTD; 3098; -.
DR   InParanoid; G3H6T5; -.
DR   KO; K00844; -.
DR   Proteomes; UP000001075; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001075};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871, ECO:0000313|EMBL:EGV93783.1};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001075};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       22    219       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      225    459       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      470    667       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      673    907       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   917 AA;  102309 MW;  C0430AA29C7067AF CRC64;
     MIAAQLLAYY FTELKDDQVK KIDKYLYAMR LSDEILIDIL TRFKKEMKNG LSRDYNPTAS
     VKMLPTFVRS IPDGSEKGDF IALDLGGSSF RILRVQVNHE KNQNVHMESE AYETPENIVH
     GSGSQLFDHV AECLGDFMEK RKIKDKKLPV GFTFSFPCRQ TKIDEAILIT WTKRFKASGV
     EGTDVVKLLN KAIKKRGDYD ANIVAVVNDT VGTMMTCGYD DQQCEVGLII GTGTNACYME
     ELRHIDLVEG DEGRMCINTE WGAFGDDGSL EDIRTEFDRE LDRGSLNPGK QLFEKMVSGM
     YMGELVRLIL VKMAKEGLLF EGRITPELLT RGKFNTSDVS AIEKNKEGIQ HAKEILTRLG
     VEPSDDDCVS VQHVCTIVPF RSANLVAATL GAILNRLRDN KGTARLRTTV GVDGSLYKTH
     PQYSRRFHKT LRRLVPDSDV RFLLSESGSG KGAALVTAVA YRLAEQHRQI EETLANFRLS
     KQTLMEVKQR MRTEMEMGLK KETHNNATVK MLPSYVRGIP DGSENGDFLA LDLGGTNFRV
     LLVKIRSGKK RTVEMHNKIY SIPIEIMQGT GEELFDHIVS CISDFLDYMG IKGPRMPLGF
     TFSFPCNQTS LDCGILITWT KGFKATDCVG HDVVTLLKDA IKRREEFDLD VVALVNDTVG
     TMMTCAYEEP TCEVGLIVGT GSNACYMEEM RNVEMVEGNQ GQMCINMEWG AFGDNGCLDD
     IRTDFDKVVD EYSLNAGKQR FEKMISGMYL GEIVRNILID FTKKGFLFRG QISEPLKTRG
     IFETKFLSQI ESDRLALLQV RAILQQLGLN STCDDSILVK TVCGVVSKRA AQLCGAGMAA
     VVEKIRENRG LDHLNVTVGV DGTLYKLHPH FSRIMHQTVK ELSPKCTVSF LLSEDGSGKG
     AALITAVGVR LRGDTTS
//
DBGET integrated database retrieval system