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Database: UniProt/TrEMBL
Entry: G3VPQ0_SARHA
LinkDB: G3VPQ0_SARHA
Original site: G3VPQ0_SARHA 
ID   G3VPQ0_SARHA            Unreviewed;       813 AA.
AC   G3VPQ0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   20-JUN-2018, entry version 44.
DE   SubName: Full=Transglutaminase 1 {ECO:0000313|Ensembl:ENSSHAP00000005155};
GN   Name=TGM1 {ECO:0000313|Ensembl:ENSSHAP00000005155};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000005155, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000005155}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000005155}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   EMBL; AEFK01008995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_003755945.1; XM_003755897.2.
DR   Ensembl; ENSSHAT00000005206; ENSSHAP00000005155; ENSSHAG00000004507.
DR   GeneID; 100918933; -.
DR   KEGG; shr:100918933; -.
DR   CTD; 7051; -.
DR   eggNOG; ENOG410IFMV; Eukaryota.
DR   eggNOG; ENOG410XQEZ; LUCA.
DR   GeneTree; ENSGT00760000119108; -.
DR   KO; K05619; -.
DR   OrthoDB; EOG091G030K; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT   DOMAIN      366    459       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    374    374       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    433    433       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    456    456       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       496    496       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       498    498       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       545    545       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       550    550       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   813 AA;  88966 MW;  65AC13BA88F71DC8 CRC64;
     MTDGSRSDVG RWGGSSWQPS VTPSPEPEPD TRSRGSGRSF WARCCSCCSC RGGADDDWGP
     EPAGPRGSGS RGSGRPGSRG SRGSGRPGSR GSGVNAAGDG VVRDGMLVVT GVDLMSGRSD
     QNRREHHTED YEYDDLIIRR GQPFLVTVSL SRPYSSSDRM ALELLIGANP EIGKGTHVII
     PVGKGGSGGW KAQVIKSNGQ HVDLKVHVSA NAIVGKFRFT VRTRTDAGEF QLPFDPRNEI
     YILFNPWCSD DPVYVEHESW RQEYVLNESG RIYYGTEAQI GERTWNYGQF DHGVLDACLY
     ILDRRGMPYA GRGDPVSVSR VISAMVNSLD DNGVLIGNWS GDYSRGTNPS AWVGSVEILL
     SYLRTGYSVP YGQCWVFAGV TTTVLRCLGI ATRTVTNYNS AHDTDTSLTM DIYFDENMKP
     LEHLNRDSVW NFHVWNDCWM RRSDLQSGFD GWQVVDATPQ ETSSGIFCCG PCSVESIKNG
     LVYMKYDTPF IFAEVNSDKV YWQRQDDGSF KIVYVEEKAI GTLICTKAVG SNMREDITHI
     YKHPEGSDAE RKAVETAAAH GSKPNIYSNR DSAEDVSVQV EAQDAVMGQD LVVNVVLTNR
     GSSRRTVKLH LYLSVTFYTG VTGPVFKDSK KEVALSPGSS ERVALPVAYS EYRPHLVDQG
     AMLLNVSGHV KENGQVIAKQ HTFRLRTPDL SLTVLGAAVV GQETEVQIIF RNPLPVTLTK
     VVFRLEGSGL QRPKVLNVGD IGGNETVTLR QTFVPVRPGR RQLIASLDSP QLSQVHGVIE
     VDVAPASGGN FFSGNRGSSR SGENVPMALR GEA
//
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