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Database: UniProt/TrEMBL
Entry: G7NWN9_MACFA
LinkDB: G7NWN9_MACFA
Original site: G7NWN9_MACFA 
ID   G7NWN9_MACFA            Unreviewed;      1365 AA.
AC   G7NWN9;
DT   25-JAN-2012, integrated into UniProtKB/TrEMBL.
DT   25-JAN-2012, sequence version 1.
DT   23-MAY-2018, entry version 54.
DE   SubName: Full=Nuclear receptor binding SET domain protein 2 {ECO:0000313|Ensembl:ENSMFAP00000016493};
DE   SubName: Full=Putative histone-lysine N-methyltransferase NSD2 {ECO:0000313|EMBL:EHH49429.1};
GN   Name=NSD2 {ECO:0000313|Ensembl:ENSMFAP00000016493};
GN   ORFNames=EGM_00061 {ECO:0000313|EMBL:EHH49429.1};
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
RN   [1] {ECO:0000313|EMBL:EHH49429.1, ECO:0000313|Proteomes:UP000009130}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CE-4 {ECO:0000313|EMBL:EHH49429.1};
RX   PubMed=22002653; DOI=10.1038/nbt.1992;
RA   Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
RA   Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
RA   Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
RA   Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
RA   Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
RA   Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
RA   Wang X., Wang J.;
RT   "Genome sequencing and comparison of two nonhuman primate animal
RT   models, the cynomolgus and Chinese rhesus macaques.";
RL   Nat. Biotechnol. 29:1019-1023(2011).
RN   [2] {ECO:0000313|Ensembl:ENSMFAP00000016493}
RP   NUCLEOTIDE SEQUENCE.
RA   Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSMFAP00000016493}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; AQIA01053478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIA01053479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIA01053480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIA01053481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIA01053482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AQIA01053483; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CM001276; EHH49429.1; -; Genomic_DNA.
DR   RefSeq; XP_005554355.1; XM_005554298.2.
DR   Ensembl; ENSMFAT00000067026; ENSMFAP00000016493; ENSMFAG00000031384.
DR   GeneID; 102132914; -.
DR   KEGG; mcf:102132914; -.
DR   CTD; 7468; -.
DR   GeneTree; ENSGT00780000121845; -.
DR   KO; K11424; -.
DR   Proteomes; UP000009130; Chromosome 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
DR   GO; GO:0003289; P:atrial septum primum morphogenesis; IEA:Ensembl.
DR   GO; GO:0003290; P:atrial septum secundum morphogenesis; IEA:Ensembl.
DR   GO; GO:0060348; P:bone development; IEA:Ensembl.
DR   GO; GO:0010452; P:histone H3-K36 methylation; IEA:Ensembl.
DR   GO; GO:0034770; P:histone H4-K20 methylation; IEA:Ensembl.
DR   GO; GO:0003149; P:membranous septum morphogenesis; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0048298; P:positive regulation of isotype switching to IgA isotypes; IEA:Ensembl.
DR   GO; GO:2001032; P:regulation of double-strand break repair via nonhomologous end joining; IEA:Ensembl.
DR   GO; GO:0070201; P:regulation of establishment of protein localization; IEA:Ensembl.
DR   Gene3D; 1.10.30.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 4.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR000313; PWWP_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF00855; PWWP; 2.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00398; HMG; 1.
DR   SMART; SM00249; PHD; 4.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00293; PWWP; 2.
DR   SMART; SM00184; RING; 2.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   SUPFAM; SSF57903; SSF57903; 3.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50812; PWWP; 2.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 2.
DR   PROSITE; PS50016; ZF_PHD_2; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009130};
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267,
KW   ECO:0000256|SAAS:SAAS00879239};
KW   Metal-binding {ECO:0000256|SAAS:SAAS01011399};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675,
KW   ECO:0000313|EMBL:EHH49429.1};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267,
KW   ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009130};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533,
KW   ECO:0000313|EMBL:EHH49429.1}; Zinc {ECO:0000256|SAAS:SAAS01006535};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00146,
KW   ECO:0000256|SAAS:SAAS01007077}.
FT   DOMAIN      222    286       PWWP. {ECO:0000259|PROSITE:PS50812}.
FT   DOMAIN      453    502       HMG box. {ECO:0000259|PROSITE:PS50118}.
FT   DOMAIN      667    713       PHD-type. {ECO:0000259|PROSITE:PS50016}.
FT   DOMAIN      717    763       RING-type. {ECO:0000259|PROSITE:PS50089}.
FT   DOMAIN      831    875       PHD-type. {ECO:0000259|PROSITE:PS50016}.
FT   DOMAIN      880    942       PWWP. {ECO:0000259|PROSITE:PS50812}.
FT   DOMAIN     1011   1061       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     1063   1180       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     1187   1203       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DNA_BIND    453    502       HMG box. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00267}.
FT   COILED      962    982       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1365 AA;  152200 MW;  7FC082CE41436B84 CRC64;
     MEFSIKQSPL SVQSVVKCIK MKQAPEILGS ANGKTPSCEV NRECSVFLSK AQLSSSLQEG
     VMQKFNGHDA LPFIPADKLK DLTSRVFNGE PGAHDAKLRF ESQEMKGIGT PPNTTPIKNG
     SPEIKLKITK TYMNGKPLFE SSICGDSAAD VSQSEENGQK PENKARRNRK RSIKYDSLLE
     QGLVEAALVS KISSPSDKKI PAKKESCPNT GRDKDHLLKY NVGDLVWSKV SGYPWWPCMV
     SADPLLHSYT KLKGQKKSAR QYHVQFFGDA PERAWIFEKS LVAFEGEGQF EKLCQESAKQ
     APTKAEKIKL LKPISGKLRA QWEMGIVQAE EAASMSVEER KAKFTFLYVG DQLHLNPQVA
     KEAGIAAESF GEMAESSGVG EEAAENPKSA REEGVPMKRR RRAKLCSSAE TLESDPDVVK
     STPQKTAEAD PRRGVASPPG RKKTTASTPR SRKGDAASQF LVFCQKHRDE VVAEHPDASG
     EEIEELLRSQ WSLLSEKQRA RYNTKFALVA PVQAEEDSGN VNGKKRNHTK RTQDPTEDVE
     VEDTPRKRLR TDKHSLRKRD TITDKTARTS SYKAMEAASS LKSQAATKNL SDACKPLKKR
     NRASTAASSA LGFSKSSSPS ASLTENEVSD SLGDEPSESP YESADETQTE VSVSSKKSER
     GVTAKKEYVC QLCEKPGSLL LCEGPCCGAF HLACLGLSRR PEGRFTCSEC ASGIHSCFVC
     KESKTDVKRC VVTQCGKFYH EACVKKYPLT VFESRGFRCP LHSCVSCHAS NPSNPRPSKG
     KMMRCVRCPV AYHSGDACLA AGCSVIASNS IICTAHFTAR KGKRHHAHVN VSWCFVCSKG
     GSLLCCESCP AAFHPDCLNI EMPDGSWFCN DCRAGKKLHF QDIIWVKLGN YRWWPAEVCH
     PKNVPPNIQK MKHEIGEFPV FFFGSKDYYW THQARVFPYM EGDRGSRYQG VRGIGRVFKN
     ALQEAEARFR EIKLQREARE TQESERKPPP YKHIKVNKPY GKVQIYTADI SEIPKCNCKP
     TDENPCGFDS ECLNRMLMFE CHPQVCPAGE FCQNQCFTKR QYPETKIIKT DGKGWGLVAK
     RDIRKGEFVN EYVGELIDEE ECMARIKHAH ENDITHFYML TIDKDRIIDA GPKGNYSRFM
     NHSCQPNCET LKWTVNGDTR VGLFAVCDIP AGTELTFNYN LDCLGNEKTV CRCGASNCSG
     FLGDRPKTST TLSSEEKGKK TKKKTRRRRA KGEGKRQSED ECFRCGDGGQ LVLCDRKFCT
     KAYHLSCLGL GKRPFGKWEC PWHHCDVCGK PSTSFCHFCP NSFCKEHQDG TAFSCTPDGR
     SYCCEHDLGA ASVRSAKTEK PPPEPGKPKG KRRRRRGWRR VTEGK
//
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