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Database: UniProt/TrEMBL
Entry: H8IT46_MYCIA
LinkDB: H8IT46_MYCIA
Original site: H8IT46_MYCIA 
ID   H8IT46_MYCIA            Unreviewed;       938 AA.
AC   H8IT46;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   28-MAR-2018, entry version 40.
DE   RecName: Full=Phosphoenolpyruvate carboxylase {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00946768};
DE            Short=PEPC {ECO:0000256|HAMAP-Rule:MF_00595};
DE            Short=PEPCase {ECO:0000256|HAMAP-Rule:MF_00595};
DE            EC=4.1.1.31 {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00946768};
GN   Name=ppc {ECO:0000256|HAMAP-Rule:MF_00595};
GN   OrderedLocusNames=OCU_31780 {ECO:0000313|EMBL:AFC44397.1};
OS   Mycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384
OS   / NCTC 13025 / 3600).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=487521 {ECO:0000313|EMBL:AFC44397.1, ECO:0000313|Proteomes:UP000008004};
RN   [1] {ECO:0000313|EMBL:AFC44397.1, ECO:0000313|Proteomes:UP000008004}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600
RC   {ECO:0000313|Proteomes:UP000008004};
RX   PubMed=22535933; DOI=10.1128/JB.00295-12;
RA   Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J.,
RA   Kook Y.H., Kim B.J.;
RT   "Complete genome sequence of Mycobacterium intracellulare strain ATCC
RT   13950T.";
RL   J. Bacteriol. 194:2750-2750(2012).
CC   -!- FUNCTION: Forms oxaloacetate, a four-carbon dicarboxylic acid
CC       source for the tricarboxylic acid cycle. {ECO:0000256|HAMAP-
CC       Rule:MF_00595, ECO:0000256|SAAS:SAAS00946761}.
CC   -!- CATALYTIC ACTIVITY: Phosphate + oxaloacetate = H(2)O +
CC       phosphoenolpyruvate + HCO(3)(-). {ECO:0000256|HAMAP-Rule:MF_00595,
CC       ECO:0000256|SAAS:SAAS00946751}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00595, ECO:0000256|SAAS:SAAS00946766};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|HAMAP-Rule:MF_00595}.
CC   -!- SIMILARITY: Belongs to the PEPCase type 1 family.
CC       {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00946753}.
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DR   EMBL; CP003322; AFC44397.1; -; Genomic_DNA.
DR   RefSeq; WP_014380460.1; NC_016946.1.
DR   EnsemblBacteria; AFC44397; AFC44397; OCU_31780.
DR   GeneID; 11909920; -.
DR   KEGG; mia:OCU_31780; -.
DR   PATRIC; fig|487521.10.peg.3188; -.
DR   KO; K01595; -.
DR   OMA; PWVFGWT; -.
DR   OrthoDB; POG091H040O; -.
DR   Proteomes; UP000008004; Chromosome.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008964; F:phosphoenolpyruvate carboxylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015977; P:carbon fixation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006107; P:oxaloacetate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   HAMAP; MF_00595; PEPcase_type1; 1.
DR   InterPro; IPR021135; PEP_COase.
DR   InterPro; IPR022805; PEP_COase_bac/pln-type.
DR   InterPro; IPR018129; PEP_COase_Lys_AS.
DR   InterPro; IPR033129; PEPCASE_His_AS.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   PANTHER; PTHR30523; PTHR30523; 1.
DR   Pfam; PF00311; PEPcase; 1.
DR   PRINTS; PR00150; PEPCARBXLASE.
DR   SUPFAM; SSF51621; SSF51621; 1.
DR   PROSITE; PS00781; PEPCASE_1; 1.
DR   PROSITE; PS00393; PEPCASE_2; 1.
PE   3: Inferred from homology;
KW   Carbon dioxide fixation {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00946757};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008004};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00595, ECO:0000256|SAAS:SAAS00946754,
KW   ECO:0000313|EMBL:AFC44397.1};
KW   Magnesium {ECO:0000256|HAMAP-Rule:MF_00595,
KW   ECO:0000256|SAAS:SAAS00946750};
KW   Pyruvate {ECO:0000313|EMBL:AFC44397.1}.
FT   ACT_SITE    164    164       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10111}.
FT   ACT_SITE    596    596       {ECO:0000256|HAMAP-Rule:MF_00595,
FT                                ECO:0000256|PROSITE-ProRule:PRU10112}.
SQ   SEQUENCE   938 AA;  102846 MW;  5BA3EAF6CEDCF0C6 CRC64;
     MADASEAPED TLEPIGAVQR TPVGREATEP MRADIRLLGA ILGDTVREQN GREVFELVER
     ARVESFRVRR SEIDRAELAR MFFRIDIHQA IPVIRAFSHF ALLANVAEDI HRERRRAVHV
     AAGEPPPDST LAATYAKLDE AQLDSDTVAD ALKGAVVAPV ITAHPTETRR RTVFVTQHRI
     TELMRLHAEG HAETDDGRNI ELELRRQVLT LWQTALIRLS RLQITDEIEV GLRYYAAAFF
     KVIPQVNAEV RDALRARWPD ADLFDEPMLQ PGSWIGGDRD GNPNVTADVV RQATGSAAFT
     ALAHYLAELT ALEQELSMSA RLVSVTPALT ELAGGCAEKA RADEPYRRAV RVIRARLSAT
     SAAILDRTPQ QVLDLGLPPY ETPAELGADL DTIDESLRGH GSALLADDRL ALLREGVRVF
     GFHLCGLDMR QNSDAHEEVI CELLAWAGVH PDYRSLPEDE RVELLAAELG TRRPLVADDA
     QLSDLARGEL GVVRAAAHAI KRYGPSAVPN YVISMCRSVS DVLEAAILLK EAGLIDASGP
     EPYCPVGISP LFETIDDLHN GATILHAILE LPIYRALVAA RGETQEVMLG YSDSNKDGGY
     LASSWAVYRA ELALVEVARK TGIRLRLFHG RGGTVGRGGG PSYEAILAQP PGAVNGSLRL
     TEQGEVIAAK YAEPQAAQRN LESLLAATLE STLLDVEGLG DAAEPAYAVL DEVAVLAQRA
     YAELVHDTPG FVDYFMASTP VSEIGSLNIG SRPTSRKPTE SISDLRAIPW VLAWSQSRVM
     LPGWYGTGSA FEQWIAAGPQ SEAERVSILH DLYQRWPFFR SVLSNLAQVL AKSDLGLAAR
     YAELVDDEEL RRRVFDKIVD EHGRTIAMHK LITGQDNLLA DNPALARSVF NRFPYLEPLN
     HLQVELLRRY RSGDDDELVQ RGILLTMNGL ASALRNSG
//
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