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Database: UniProt/TrEMBL
Entry: H8WAX5_MARHY
LinkDB: H8WAX5_MARHY
Original site: H8WAX5_MARHY 
ID   H8WAX5_MARHY            Unreviewed;       760 AA.
AC   H8WAX5;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   22-NOV-2017, entry version 29.
DE   SubName: Full=Isocitrate dehydrogenase {ECO:0000313|EMBL:CCG93582.1};
DE            EC=1.1.1.42 {ECO:0000313|EMBL:CCG93582.1};
GN   Name=idh {ECO:0000313|EMBL:CCG93582.1};
GN   ORFNames=MARHY0078 {ECO:0000313|EMBL:CCG93582.1};
OS   Marinobacter hydrocarbonoclasticus ATCC 49840.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Alteromonadaceae; Marinobacter.
OX   NCBI_TaxID=1163748 {ECO:0000313|EMBL:CCG93582.1, ECO:0000313|Proteomes:UP000007884};
RN   [1] {ECO:0000313|EMBL:CCG93582.1, ECO:0000313|Proteomes:UP000007884}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49840 {ECO:0000313|EMBL:CCG93582.1};
RX   PubMed=22689231; DOI=10.1128/JB.00500-12;
RA   Grimaud R., Ghiglione J.F., Cagnon C., Lauga B., Vaysse P.J.,
RA   Rodriguez-Blanco A., Mangenot S., Cruveiller S., Barbe V., Duran R.,
RA   Wu L.F., Talla E., Bonin P., Michotey V.;
RT   "Genome Sequence of the Marine Bacterium Marinobacter
RT   hydrocarbonoclasticus SP17, Which Forms Biofilms on Hydrophobic
RT   Organic Compounds.";
RL   J. Bacteriol. 194:3539-3540(2012).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR009407-3};
CC       Note=Binds 1 Mg(2+) or Mn(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR009407-3};
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DR   EMBL; FO203363; CCG93582.1; -; Genomic_DNA.
DR   EnsemblBacteria; CCG93582; CCG93582; MARHY0078.
DR   KEGG; mhc:MARHY0078; -.
DR   PATRIC; fig|2743.3.peg.77; -.
DR   KO; K00031; -.
DR   OrthoDB; POG091H0B3N; -.
DR   Proteomes; UP000007884; Chromosome.
DR   GO; GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   InterPro; IPR004436; Isocitrate_DH_NADP_mono.
DR   PANTHER; PTHR36999; PTHR36999; 1.
DR   Pfam; PF03971; IDH; 1.
DR   PIRSF; PIRSF009407; IDH_monmr; 1.
DR   TIGRFAMs; TIGR00178; monomer_idh; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007884};
KW   Magnesium {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR009407-3};
KW   Oxidoreductase {ECO:0000313|EMBL:CCG93582.1}.
FT   REGION      147    154       Substrate binding. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   METAL       365    365       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       563    563       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   METAL       567    567       Magnesium or manganese.
FT                                {ECO:0000256|PIRSR:PIRSR009407-3}.
FT   BINDING     160    160       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   BINDING     562    562       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR009407-2}.
FT   SITE        270    270       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
FT   SITE        435    435       Critical for catalysis.
FT                                {ECO:0000256|PIRSR:PIRSR009407-1}.
SQ   SEQUENCE   760 AA;  84994 MW;  C106C3F6C8CCC30A CRC64;
     MTVLNPPNSL RTKMTSSKAK IVYTLTDEAP ALATRSLLPI LETFAKPAGI DFETSDISLA
     ARILAGFPDY LEEDQRVPDA LAELGEYTKD PDANIIKLPN ISASIPQLRA AIKELNEQGY
     KVPEYKEHPE TDEEKEIHAR YSKVLGSAVN PVLREGNSDR RAPAAVKAFA RKYPHTMGEW
     SPASRTHVAH MRGGDFYSSE QSVTLDKATN ARIVFENKKG EQTVLKSDLP LQEGEVLDGM
     FMSKKALVKF FEDAIADCEN TGVMFSLHVK ATMMKISHPI VFGHAVKVFY KELFDKYGEL
     FQEIGVNPNN GLSSVIEKIK QLPESKQEQI QEDLHACYEH RPEIAMVDSV KGITNLHVPS
     DVIVDASMPA MIRNSGKMWA RDGKLKDTKA VMPESTYATI YQEVINFCKT HGAFDPTTMG
     TVPNVGLMAQ KAEEYGSHDK TFEMKEDGVV RVVAEDGTVL TEHKVEEGDI WRACQTKDLP
     IRDWVKLAVN RSRSSGMPAV FWLDDERAHD AQLIKKVKTY LADLDTEGLD IRIMSPVRAI
     RWTMERLIRG LDTISVTGNV LRDYLTDLFP ILELGTSAKM LSIVPLLNGG GLYETGAGGS
     APKHVQQLIQ ENHLRWDSLG EFLATAVSLD ELGEKQNNER ARLLGQTMDK ATERLLENNQ
     SPSRVTGELD NRGSHFHLAR YWAEELSKQD EDKELKEFFT KLSAQLEENK DKILEEMTVV
     QGHPADIGGY YHPPMEKVCE VMQPSATFNK ILAEARDSVN
//
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