GenomeNet

Database: UniProt/TrEMBL
Entry: H9H6E5_MONDO
LinkDB: H9H6E5_MONDO
Original site: H9H6E5_MONDO 
ID   H9H6E5_MONDO            Unreviewed;       917 AA.
AC   H9H6E5;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   28-MAR-2018, entry version 41.
DE   SubName: Full=Hexokinase domain containing 1 {ECO:0000313|Ensembl:ENSMODP00000013383};
GN   Name=HKDC1 {ECO:0000313|Ensembl:ENSMODP00000013383};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000013383, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000013383, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000013383}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
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DR   RefSeq; XP_001364147.1; XM_001364110.3.
DR   STRING; 13616.ENSMODP00000013383; -.
DR   Ensembl; ENSMODT00000013628; ENSMODP00000013383; ENSMODG00000010681.
DR   GeneID; 100015984; -.
DR   KEGG; mdo:100015984; -.
DR   CTD; 80201; -.
DR   eggNOG; KOG1369; Eukaryota.
DR   eggNOG; COG5026; LUCA.
DR   GeneTree; ENSGT00390000017159; -.
DR   InParanoid; H9H6E5; -.
DR   KO; K00844; -.
DR   OMA; KIETRHV; -.
DR   OrthoDB; EOG091G08MD; -.
DR   TreeFam; TF314238; -.
DR   Proteomes; UP000002280; Unplaced.
DR   Bgee; ENSMODG00000010681; -.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008865; F:fructokinase activity; IBA:GO_Central.
DR   GO; GO:0004340; F:glucokinase activity; IBA:GO_Central.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0019158; F:mannokinase activity; IBA:GO_Central.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IBA:GO_Central.
DR   GO; GO:0006096; P:glycolytic process; IBA:GO_Central.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 1.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       22    219       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      225    459       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      470    667       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      673    907       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   COILED      342    362       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   917 AA;  102519 MW;  0CA256EEFC9D4FF9 CRC64;
     MFAVHLLAFY FTKLKEDQIK KVDRFLYHLR LSDDTLLDIM TRFRAEMEKG LGKDTNPTAC
     VKMLPTFVRA IPDGSEKGEF LALDLGGSKF RVLTVRVSEE GKPNVHMESQ IYPTPKEIIH
     GSGSELFDYV ADCAADFVKT RDLAHKKLPL GLTFSFPCQQ SKLEEGILLS WTKKFKVRGV
     QDTDVVSSLT RALRRHQDVD VDVLALVNDT VATMMTCAYD DPRCEVGVII GTGTNACYME
     DMSNIDLVEG DEGRMAINTE WGAFGEDGAL EDIRTEFDRE LDLGSINPGK QLFEKMISGL
     YIGELVRLIL LKMTKAGLLF QGEKSSALHT KGKIETRHVA LMEKYKEGLQ NTREILRELG
     LEPSEEDCVA VQHVCTIVSF RSANLCAAAL AAILNRLREN RRLTRLRTTV GMDGTLYKTH
     PQYPKRLHKV VRKLVPNCDV RFLLSESGSA KGAAMVTAVA ARVQAQRKVI DEVLALFQLT
     REHLVSVKNK MRSEMEYGLK KETQPLATVK MLPTYVCAMP DGTEKGKYLA LDLGGTNFRV
     LLVKIRSGRR SVRMYNKIFA IPLEIMQGTG EELFDHIVQC IADFLDYMGI KGASKLPLGF
     TFSFPCKQNC LDKGILVEWT KGFKATDCEG EDVVDMLREA IKRRNEFELD VVAVLNDTVG
     TMMTCAYEDP ACEIGLIAGT GSNVCYMEEM RNIELVEGDE GIMCINTEWG GFGDNGCLDE
     IRTQYDVEVD EGSLNPGKQR YEKMTSGMYL GEIVRQILID LTKHGLLFRG QISERLRTRG
     IFETKFLSQI ESDRLALLQV RRILQQLGLD STCEDSIVVK EVCGAVSRRA AQLCGAGLAA
     IVEKRREDRG LERLAITVGV DGTLYKLHPH FSRILRETVH ALAPRCDVTF MLSEDGSGKG
     AALITAVAKR LHLKKDH
//
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