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Database: UniProt/TrEMBL
Entry: K5WK74_AGABU
LinkDB: K5WK74_AGABU
Original site: K5WK74_AGABU 
ID   K5WK74_AGABU            Unreviewed;       400 AA.
AC   K5WK74;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   18-JUL-2018, entry version 27.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00894283};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00894283};
GN   ORFNames=AGABI1DRAFT_102828 {ECO:0000313|EMBL:EKM75681.1};
OS   Agaricus bisporus var. burnettii (strain JB137-S8 / ATCC MYA-4627 /
OS   FGSC 10392) (White button mushroom).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Agaricomycetes; Agaricomycetidae; Agaricales; Agaricaceae; Agaricus.
OX   NCBI_TaxID=597362 {ECO:0000313|EMBL:EKM75681.1, ECO:0000313|Proteomes:UP000008493};
RN   [1] {ECO:0000313|Proteomes:UP000008493}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JB137-S8 / ATCC MYA-4627 / FGSC 10392
RC   {ECO:0000313|Proteomes:UP000008493};
RX   PubMed=23045686; DOI=10.1073/pnas.1206847109;
RA   Morin E., Kohler A., Baker A.R., Foulongne-Oriol M., Lombard V.,
RA   Nagy L.G., Ohm R.A., Patyshakuliyeva A., Brun A., Aerts A.L.,
RA   Bailey A.M., Billette C., Coutinho P.M., Deakin G., Doddapaneni H.,
RA   Floudas D., Grimwood J., Hilden K., Kuees U., LaButti K.M.,
RA   Lapidus A., Lindquist E.A., Lucas S.M., Murat C., Riley R.W.,
RA   Salamov A.A., Schmutz J., Subramanian V., Woesten H.A.B., Xu J.,
RA   Eastwood D.C., Foster G.D., Sonnenberg A.S., Cullen D., de Vries R.P.,
RA   Lundell T., Hibbett D.S., Henrissat B., Burton K.S., Kerrigan R.W.,
RA   Challen M.P., Grigoriev I.V., Martin F.;
RT   "Genome sequence of the button mushroom Agaricus bisporus reveals
RT   mechanisms governing adaptation to a humic-rich ecological niche.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:17501-17506(2012).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00894227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00894298}.
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DR   EMBL; JH971410; EKM75681.1; -; Genomic_DNA.
DR   RefSeq; XP_007333740.1; XM_007333678.1.
DR   ProteinModelPortal; K5WK74; -.
DR   EnsemblFungi; EKM75681; EKM75681; AGABI1DRAFT_102828.
DR   GeneID; 18821868; -.
DR   KEGG; abp:AGABI1DRAFT102828; -.
DR   InParanoid; K5WK74; -.
DR   KO; K11405; -.
DR   OrthoDB; EOG092C386A; -.
DR   Proteomes; UP000008493; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; PTHR10625; 2.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; SSF52768; 1.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00894233};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008493};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00870288};
KW   Nucleus {ECO:0000256|SAAS:SAAS00894277};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008493};
KW   Transcription {ECO:0000256|SAAS:SAAS00894309};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00894290}.
FT   DOMAIN       26    336       Hist_deacetyl. {ECO:0000259|Pfam:
FT                                PF00850}.
SQ   SEQUENCE   400 AA;  43760 MW;  775CA22031390C6B CRC64;
     MSSSTTTARV AYIVSAQLIK IASLLPSNKK RSFVVHSLIK SLGLLEPGKV QIYTPRNATR
     QDLAMYHASG YLEFILDPKN CNEHDEHRHG ASEREAMKVE YGLEDDCPLF TGLSDYVTLV
     AGATLTAVDA LRYDISDIAI NWDGGRHHAS KSRASGFCYV ADCVLAILAL KSIPRPPSKA
     NEPTKPLPRV LYLDLDLHFS DSVSAAFTIH HTSPGFFPVS PKAELPDPST PRFDPFSLSI
     PLREGASNKT YCAIWSIVEE LKDIMMPDFI VIQCGTDALA GDPCAILNWS LGGGEGSLGW
     CVSRIINEWK GKKLFLGGGG YNSANAARAW AYITSVALGN PLDLEAHIPD HPGFPLYAPS
     FTLDVPAGNM RDQNSPEYLH TIKTRFDKVI PLVRQRMGCV
//
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