GenomeNet

Database: UniProt/TrEMBL
Entry: K7A6Y3_PANTR
LinkDB: K7A6Y3_PANTR
Original site: K7A6Y3_PANTR 
ID   K7A6Y3_PANTR            Unreviewed;       885 AA.
AC   K7A6Y3; H2RD42;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   25-APR-2018, entry version 23.
DE   RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903};
DE            EC=2.1.1.43 {ECO:0000256|PROSITE-ProRule:PRU00903};
GN   Name=KMT5B {ECO:0000313|Ensembl:ENSPTRP00000058287,
GN   ECO:0000313|VGNC:VGNC:7658};
GN   Synonyms=SUV420H1 {ECO:0000313|EMBL:JAA13491.1};
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598 {ECO:0000313|EMBL:JAA13491.1};
RN   [1] {ECO:0000313|Ensembl:ENSPTRP00000058287, ECO:0000313|Proteomes:UP000002277}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the
RT   human genome.";
RL   Nature 437:69-87(2005).
RN   [2] {ECO:0000313|Ensembl:ENSPTRP00000058287}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|EMBL:JAA13491.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA09135.1}, Skeletal muscle
RC   {ECO:0000313|EMBL:JAA42737.1}, Skin {ECO:0000313|EMBL:JAA31693.1}, and
RC   Smooth vascular {ECO:0000313|EMBL:JAA13491.1};
RA   Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
RT   "De novo assembly of the reference chimpanzee transcriptome from
RT   NextGen mRNA sequences.";
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|PROSITE-ProRule:PRU00903}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. Suvar4-20 subfamily. {ECO:0000256|PROSITE-
CC       ProRule:PRU00903}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AACZ04016239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; GABC01002203; JAA09135.1; -; mRNA.
DR   EMBL; GABF01008654; JAA13491.1; -; mRNA.
DR   EMBL; GABD01001407; JAA31693.1; -; mRNA.
DR   EMBL; GABE01002002; JAA42737.1; -; mRNA.
DR   RefSeq; XP_009421853.2; XM_009423578.2.
DR   STRING; 9598.ENSPTRP00000058287; -.
DR   Ensembl; ENSPTRT00000066707; ENSPTRP00000058287; ENSPTRG00000003981.
DR   GeneID; 451378; -.
DR   KEGG; ptr:451378; -.
DR   CTD; 51111; -.
DR   VGNC; VGNC:7658; KMT5B.
DR   eggNOG; KOG2589; Eukaryota.
DR   eggNOG; ENOG410XPH8; LUCA.
DR   GeneTree; ENSGT00520000055640; -.
DR   KO; K11429; -.
DR   OMA; SGCLTRH; -.
DR   OrthoDB; EOG091G0IUY; -.
DR   TreeFam; TF106433; -.
DR   Proteomes; UP000002277; Chromosome 11.
DR   Bgee; ENSPTRG00000003981; -.
DR   GO; GO:0000780; C:condensed nuclear chromosome, centromeric region; IEA:Ensembl.
DR   GO; GO:0042799; F:histone methyltransferase activity (H4-K20 specific); IEA:UniProtKB-UniRule.
DR   GO; GO:0034773; P:histone H4-K20 trimethylation; IEA:UniProtKB-UniRule.
DR   InterPro; IPR025790; Hist-Lys_N-MTase_Suvar4-20.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS51570; SAM_MT43_SUVAR420_2; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002277};
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU00903};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002277};
KW   S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU00903};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU00903}.
FT   DOMAIN      193    308       SET. {ECO:0000259|PROSITE:PS50280}.
SQ   SEQUENCE   885 AA;  99173 MW;  F1B99A7A3EFD65DC CRC64;
     MKWLGESKNM VVNGRRNGGK LSNDHQQNQS KLQHTGKDTL KAGKNAVERR SNRCNGNSGF
     EGQSRYVPSS GMSAKELCEN DDLATSLVLD PYLGFQTHKM NTSAFPSRSS RHFSKSDSFS
     HNNPVRFRPI KGRQEELKEV IERFKKDEHL EKAFKCLTSG EWARHYFLNK NKMQEKLFKE
     HVFIYLRMFA TDSGFEILPC NRYSSEQNGA KIVATKEWKR NDKIELLVGC IAELSEIEEN
     MLLRHGENDF SVMYSTRKNC AQLWLGPAAF INHDCRPNCK FVSTGRDTAC VKALRDIEPG
     EEISCYYGDG FFGENNEFCE CYTCERRGTG AFKSRVGLPA PAPVINSKYG LRETDKRLNR
     LKKLGDSSKN SDSQSVSSNT DADTTQEKNN ATSNRKSSVG VKKNSKSRTL TRQSMSRIPA
     SSNSTSSKLT HINNSRVPKK LKKPAKPLLS KIKLRNHCKR LEQKNASRKL EMGNLVLKEP
     KVVLYKNLPI KKDKEPEGPA QAAVASGCLT RHAAREHRQN PVRGAHSQGE SSPCTYITRR
     SVRTRTNLKE ASDIKLEPNT LDGYKSSVTE PCPDSGEQPQ PAPVLQEEEL AHETAQKGEA
     KCHKSDTGMS KKKSRQGKLV KQFAKIEEST PVHDSPGKDD AVPDLMGPHS DQGEHSGTVG
     VPVSYTDCAP SPVGCSVVTS DSFKTKDSFR TAKSKKKRRI TRYDAQLILE NNSGIPKLTL
     RRRHDSSSKT NDQENDGMNS SKISIKLSKD HDNDNNLYVA KLNNGFNSGS GSSSTKLKIQ
     LKRDEENRGS YTEGLHENGV CCSDPLSLLE SRMEVDDYSQ YEEESTDDSS SSEGDEEEDD
     YDDDFEDDFI PLPPAKRLRL IVGKDSIDID ISSRRREDQS LRLNA
//
DBGET integrated database retrieval system