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Database: UniProt/TrEMBL
Entry: L8IUK1_9CETA
LinkDB: L8IUK1_9CETA
Original site: L8IUK1_9CETA 
ID   L8IUK1_9CETA            Unreviewed;       732 AA.
AC   L8IUK1;
DT   03-APR-2013, integrated into UniProtKB/TrEMBL.
DT   03-APR-2013, sequence version 1.
DT   20-JUN-2018, entry version 30.
DE   SubName: Full=Coagulation factor XIII A chain {ECO:0000313|EMBL:ELR59683.1};
GN   ORFNames=M91_12590 {ECO:0000313|EMBL:ELR59683.1};
OS   Bos mutus (wild yak).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=72004 {ECO:0000313|EMBL:ELR59683.1};
RN   [1] {ECO:0000313|EMBL:ELR59683.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YakQH1 {ECO:0000313|EMBL:ELR59683.1};
RX   PubMed=22751099; DOI=10.1038/ng.2343;
RA   Qiu Q., Zhang G., Ma T., Qian W., Wang J., Ye Z., Cao C., Hu Q.,
RA   Kim J., Larkin D.M., Auvil L., Capitanu B., Ma J., Lewin H.A.,
RA   Qian X., Lang Y., Zhou R., Wang L., Wang K., Xia J., Liao S., Pan S.,
RA   Lu X., Hou H., Wang Y., Zang X., Yin Y., Ma H., Zhang J., Wang Z.,
RA   Zhang Y., Zhang D., Yonezawa T., Hasegawa M., Zhong Y., Liu W.,
RA   Zhang Y., Huang Z., Zhang S., Long R., Yang H., Wang J., Lenstra J.A.,
RA   Cooper D.N., Wu Y., Wang J., Shi P., Wang J., Liu J.;
RT   "The yak genome and adaptation to life at high altitude.";
RL   Nat. Genet. 44:946-949(2012).
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit.
CC       {ECO:0000256|PIRSR:PIRSR000459-2};
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DR   EMBL; JH880690; ELR59683.1; -; Genomic_DNA.
DR   RefSeq; XP_005891215.1; XM_005891153.2.
DR   GeneID; 102282528; -.
DR   KEGG; bom:102282528; -.
DR   CTD; 2162; -.
DR   KO; K03917; -.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR   GO; GO:0072378; P:blood coagulation, fibrin clot formation; IEA:InterPro.
DR   GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   Gene3D; 3.90.260.10; -; 1.
DR   InterPro; IPR034810; Factor_XIII_A.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain_like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   PANTHER; PTHR11590:SF42; PTHR11590:SF42; 1.
DR   Pfam; PF00927; Transglut_C; 2.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF49309; SSF49309; 2.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2}.
FT   DOMAIN      307    400       TGc. {ECO:0000259|SMART:SM00460}.
FT   ACT_SITE    315    315       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    374    374       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   ACT_SITE    397    397       {ECO:0000256|PIRSR:PIRSR000459-1}.
FT   METAL       437    437       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       439    439       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       486    486       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
FT   METAL       491    491       Calcium. {ECO:0000256|PIRSR:PIRSR000459-
FT                                2}.
SQ   SEQUENCE   732 AA;  82731 MW;  C6BBE8B7D374D697 CRC64;
     MSESSGTAFG GRRAIPPNTS NAAENDPPTV ELQGLVPRGF NPQDYLNVTN VHLFKERWDS
     NKVDHHTDKY SNDKLIVRRG QSFYIQIDFN RPYDPRRDLF RVEYVIGLYP QENKGTYIPV
     PLVSELQSGK WGAKVVMRED RSVRLSVQSS ADCIVGKFRM YVAVWTPYGV IRTSRNPETD
     TYILFNPWCE EDAVYLENEK EREECVLNDI GVIFYGDFND IKSRSWSYGQ FEDSILDACL
     FVMDKANMDL SGRGNPIKVS RVGSAMINAK DDEGVIAGSW DNVYAYGVPP SAWTGSVDIL
     LEYKSSQKPV RYGQCWVFAG VFNTFLRCLG IPARVVTNYF SAHDNDANLQ LDIFLEEDGN
     VNSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQVVDSTP QENSDGMYRC GPASVQAIKH
     GHVCFQFDAP FVFAEVNSDL VYVTAKKDGT HVVEALDTTH IGKLIVTKEI GGDGMKDITD
     TYKFQEGQEE ERLALETAMM YGAKKALNTE GVLKSKSDVR MNFEVENAVL GRDLKVIITF
     RNNGSARYTV TAYLSGNISF YTGVSKAEFK NETFEVTLEP LSFKREEVLI GAGEYMGQLL
     EQAFLHFFVT ARVNETRDVL AKQKSIALTV PKVVIKVRGA QVVGSDMVVT VEFTNPLKET
     LRNVWIRLDG PGVTKPLRKM FREIRPNSTV QWEELCRPWV SGPRKLIASL TSDSLRHVYG
     ELDLQIQRRP SM
//
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