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Database: UniProt/TrEMBL
Entry: Q55M56_CRYNB
LinkDB: Q55M56_CRYNB
Original site: Q55M56_CRYNB 
ID   Q55M56_CRYNB            Unreviewed;       555 AA.
AC   Q55M56;
DT   24-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   24-MAY-2005, sequence version 1.
DT   22-NOV-2017, entry version 71.
DE   RecName: Full=Histone deacetylase {ECO:0000256|SAAS:SAAS00894283};
DE            EC=3.5.1.98 {ECO:0000256|SAAS:SAAS00894283};
GN   OrderedLocusNames=CNBI1560 {ECO:0000313|EMBL:EAL18895.1};
OS   Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS   (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Tremellomycetes; Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=283643 {ECO:0000313|EMBL:EAL18895.1, ECO:0000313|Proteomes:UP000001435};
RN   [1] {ECO:0000313|Proteomes:UP000001435}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B-3501A {ECO:0000313|Proteomes:UP000001435};
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J.,
RA   D'Souza C.A., Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J.,
RA   Huang J.C., Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I.,
RA   Kwon-Chung K.J., Lengeler K.B., Maiti R., Marra M.A., Marra R.E.,
RA   Mathewson C.A., Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L.,
RA   Schein J.E., Shvartsbeyn A., Shin H., Shumway M., Specht C.A.,
RA   Suh B.B., Tenney A., Utterback T.R., Wickes B.L., Wortman J.R.,
RA   Wye N.H., Kronstad J.W., Lodge J.K., Heitman J., Davis R.W.,
RA   Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen
RT   Cryptococcus neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC       {ECO:0000256|SAAS:SAAS00894227}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00894298}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EAL18895.1}.
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DR   EMBL; AAEY01000044; EAL18895.1; -; Genomic_DNA.
DR   RefSeq; XP_773542.1; XM_768449.1.
DR   ProteinModelPortal; Q55M56; -.
DR   STRING; 283643.XP_773542.1; -.
DR   EnsemblFungi; EAL18895; EAL18895; CNBI1560.
DR   GeneID; 4938115; -.
DR   KEGG; cnb:CNBI1560; -.
DR   EuPathDB; FungiDB:CNBI1560; -.
DR   eggNOG; KOG1342; Eukaryota.
DR   eggNOG; COG0123; LUCA.
DR   KO; K06067; -.
DR   OrthoDB; EOG092C386A; -.
DR   Proteomes; UP000001435; Chromosome 9.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IEA:UniProtKB-EC.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.800.20; -; 1.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR023801; His_deacetylse_dom.
DR   InterPro; IPR037138; His_deacetylse_dom_sf.
DR   InterPro; IPR023696; Ureohydrolase_dom_sf.
DR   PANTHER; PTHR10625; PTHR10625; 1.
DR   Pfam; PF00850; Hist_deacetyl; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   SUPFAM; SSF52768; SSF52768; 2.
PE   4: Predicted;
KW   Chromatin regulator {ECO:0000256|SAAS:SAAS00894233};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001435};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00870288};
KW   Nucleus {ECO:0000256|SAAS:SAAS00894277};
KW   Transcription {ECO:0000256|SAAS:SAAS00894309};
KW   Transcription regulation {ECO:0000256|SAAS:SAAS00894290}.
FT   DOMAIN       75    490       Hist_deacetyl. {ECO:0000259|Pfam:
FT                                PF00850}.
SQ   SEQUENCE   555 AA;  61731 MW;  13D9062BF5B5B0E9 CRC64;
     MTNLHFGVCS STNRLHQKNP TNVLLCLVCI ISSAQSYISP DYQLMIPSTS STNHSAFRVS
     YLWSPALQRL SDDLPSNVGR SSMVHDLIKS FDLLDFEELK ERFSKSDKPE DEDGKSEDDD
     DNEADRNEVN NGDKQGADGE PQRRKPGSPT ESPPHAQNKK ATVVFPQPSL GTKACLLKYH
     DRSYIERLLM AHIDRDPNDP THLPSSPSSS ASSPRPAKIA RTDPYNLSHD NPVFPTLASY
     ISHVTAATST ACRLLATDKA DWAVCWDGGR HHAKRKEAGG FCYVNDLVLG GLLLSREGRI
     PLPLKEGEDP KRQRTRAPRI LYLDMDLHYS DGVSAAFHSP TVYPYPLKEG ITPPKPPNVL
     TLSVHHSSPI FFPPPTPLSL LPSPDTESPF SLSIPLSAYP SRQTYAKVFN QCIQPIREAW
     DPDYIILQLG TDGLPGDRVG QYGNWSVDGE GGIKWVVERV KEWGKKVCVT GGGGYRHDNA
     ARAWAEVMGV LLDRDFVEDM PIPHHDHFEQ YAPSFTLQVP DSHMRDENKP EDLEKAAEVF
     NVLAERIKII VDANS
//
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