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Database: UniProt/TrEMBL
Entry: Q8IJJ4_PLAF7
LinkDB: Q8IJJ4_PLAF7
Original site: Q8IJJ4_PLAF7 
ID   Q8IJJ4_PLAF7            Unreviewed;       640 AA.
AC   Q8IJJ4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   22-SEP-2009, sequence version 2.
DT   23-MAY-2018, entry version 109.
DE   RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE            EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN   ORFNames=PF3D7_1020800 {ECO:0000313|EMBL:CZT98463.1};
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329 {ECO:0000313|EMBL:CZT98463.1, ECO:0000313|Proteomes:UP000001450};
RN   [1] {ECO:0000313|EMBL:CZT98463.1, ECO:0000313|Proteomes:UP000001450}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate 3D7 {ECO:0000313|Proteomes:UP000001450};
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.,
RA   Eisen J.A., Rutherford K., Salzberg S.L., Craig A., Kyes S.,
RA   Chan M.S., Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S.,
RA   Pertea M., Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B.,
RA   Martin D.M., Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A.,
RA   McFadden G.I., Cummings L.M., Subramanian G.M., Mungall C.,
RA   Venter J.C., Carucci D.J., Hoffman S.L., Newbold C., Davis R.W.,
RA   Fraser C.M., Barrell B.;
RT   "Genome sequence of the human malaria parasite Plasmodium
RT   falciparum.";
RL   Nature 419:498-511(2002).
CC   -!- COFACTOR:
CC       Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC         Evidence={ECO:0000256|RuleBase:RU003423};
CC   -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU003423}.
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DR   EMBL; LN999944; CZT98463.1; -; Genomic_DNA.
DR   RefSeq; XP_001347486.2; XM_001347450.2.
DR   EnsemblProtists; CZT98463; CZT98463; PF3D7_1020800.
DR   GeneDB; PF3D7_1020800.1:pep; -.
DR   GeneID; 810359; -.
DR   KEGG; pfa:PF10_0407; -.
DR   EuPathDB; PlasmoDB:PF3D7_1020800; -.
DR   KO; K00627; -.
DR   OMA; KAVARNM; -.
DR   Reactome; R-PFA-389661; Glyoxylate metabolism and glycine degradation.
DR   Reactome; R-PFA-70268; Pyruvate metabolism.
DR   Proteomes; UP000001450; Chromosome 10.
DR   GO; GO:0020011; C:apicoplast; IDA:GeneDB.
DR   GO; GO:0004742; F:dihydrolipoyllysine-residue acetyltransferase activity; IDA:GeneDB.
DR   GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IC:GeneDB.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; TAS:GeneDB.
DR   Gene3D; 3.30.559.10; -; 1.
DR   InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR   InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00198; 2-oxoacid_dh; 1.
DR   Pfam; PF00364; Biotin_lipoyl; 2.
DR   SUPFAM; SSF51230; SSF51230; 2.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 2.
DR   PROSITE; PS00189; LIPOYL; 2.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:CZT98463.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001450};
KW   Lipoyl {ECO:0000256|RuleBase:RU003423};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001450};
KW   Transferase {ECO:0000256|RuleBase:RU003423,
KW   ECO:0000313|EMBL:CZT98463.1}.
SQ   SEQUENCE   640 AA;  73890 MW;  185718D379E16CBC CRC64;
     MLYNLIILIF YLRFSKCISK NNNYGYINFG TFSNVVNNSN NLRNRKNVVF SKIEIKMPAL
     SSTMTTGKIV KWNKNIGDYV NLGDIIMTVE SDKADMDVEA FDEGFLRVKR LEDGCEANVG
     DVLGVLTTEE NENMDEKKYN DGDINKTENE IKVLNPDKDK SEQIIKEDIH FVKKHINDDV
     NEEKIFIPFI KCKKKKAKIN KWLKNENDFV KKNDLLLYVE DDKSTIEVES PYSGIIKKLL
     VKEGQFVDLD KEVAIISITE EKDNEKEKIE EPFKNKEDEE INRDNILIHY INKIKKSEEG
     RKFLKNLSEQ EEKTLEERLK LNYEKYNKIS NDLFRSSEST KDYVLKEKEN ESQYEMVLPS
     ASELMRQNKL NPKDITNRKT PNRITYEDVD AFLNGHKNNS TNVTYCEKPK VETIEYGDPK
     TVDMTNIQKS IKNNMMLTLT VPVFRVTHLI KTNELLKLYE KVKQKISMSV IINKCVSSVL
     LNHPLIYSTY IDKDNGKILY NKDVNIGNAL GLPDSLLTPV LKKVDKKDIY TLANEWKILV
     EKGKNGLLSS NDMTGSNFYI SNLGMFNTYQ FDAILPKNSS CILSIGTNIG SIDNLEDLKI
     QKGMMMTLTC DHRHIYGSHA AAFMNDLSKF IEKDIMKIFL
//
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