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Database: UniProt/TrEMBL
Entry: U3JBK4_FICAL
LinkDB: U3JBK4_FICAL
Original site: U3JBK4_FICAL 
ID   U3JBK4_FICAL            Unreviewed;       917 AA.
AC   U3JBK4;
DT   13-NOV-2013, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 1.
DT   23-MAY-2018, entry version 40.
DE   SubName: Full=Hexokinase 2 {ECO:0000313|Ensembl:ENSFALP00000000158};
GN   Name=HK2 {ECO:0000313|Ensembl:ENSFALP00000000158};
OS   Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
OC   Ficedula.
OX   NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000000158, ECO:0000313|Proteomes:UP000016665};
RN   [1] {ECO:0000313|Ensembl:ENSFALP00000000158}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2013) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the hexokinase family.
CC       {ECO:0000256|SAAS:SAAS00672880}.
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DR   EMBL; AGTO01021790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_005057993.1; XM_005057936.1.
DR   Ensembl; ENSFALT00000000159; ENSFALP00000000158; ENSFALG00000000141.
DR   GeneID; 101810322; -.
DR   KEGG; fab:101810322; -.
DR   GeneTree; ENSGT00390000017159; -.
DR   KO; K00844; -.
DR   OMA; HAIAPVK; -.
DR   OrthoDB; EOG091G08MD; -.
DR   Proteomes; UP000016665; Unplaced.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR   GO; GO:0004396; F:hexokinase activity; IEA:InterPro.
DR   GO; GO:0008637; P:apoptotic mitochondrial changes; IEA:Ensembl.
DR   GO; GO:0001678; P:cellular glucose homeostasis; IEA:InterPro.
DR   GO; GO:0072655; P:establishment of protein localization to mitochondrion; IEA:Ensembl.
DR   GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR   GO; GO:0072656; P:maintenance of protein location in mitochondrion; IEA:Ensembl.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
DR   GO; GO:1904925; P:positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization; IEA:Ensembl.
DR   InterPro; IPR001312; Hexokinase.
DR   InterPro; IPR019807; Hexokinase_BS.
DR   InterPro; IPR022673; Hexokinase_C.
DR   InterPro; IPR022672; Hexokinase_N.
DR   PANTHER; PTHR19443; PTHR19443; 4.
DR   Pfam; PF00349; Hexokinase_1; 2.
DR   Pfam; PF03727; Hexokinase_2; 2.
DR   PROSITE; PS00378; HEXOKINASE_1; 2.
DR   PROSITE; PS51748; HEXOKINASE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00672869};
KW   Complete proteome {ECO:0000313|Proteomes:UP000016665};
KW   Glycolysis {ECO:0000256|SAAS:SAAS00672870};
KW   Kinase {ECO:0000256|SAAS:SAAS00672871};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00672883};
KW   Reference proteome {ECO:0000313|Proteomes:UP000016665};
KW   Transferase {ECO:0000256|SAAS:SAAS00672884}.
FT   DOMAIN       22    219       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      225    459       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
FT   DOMAIN      471    667       Hexokinase_1. {ECO:0000259|Pfam:PF00349}.
FT   DOMAIN      673    907       Hexokinase_2. {ECO:0000259|Pfam:PF03727}.
SQ   SEQUENCE   917 AA;  102454 MW;  04C1538BEF29C6F0 CRC64;
     MIASHLLAYF FTELNHDQTQ KIDKYLYHMR LSDETLLEVS QRFEKEMEKG LGADTNPTAS
     VKMLPTFVRS TPDGTEDGDF LALDLGGTNF RVLRVKVSDN GLRKVEMENQ IYAIPEELMR
     GSGVQLFDHI AECLANFLDK LQIKDKKLPL GFTFSFPCHQ TKLDESILVT WTKGFKCSSV
     EGRDVVSLLR KSIRKRGDFD IDIVAVVNDT VGTMMTCGYD DHNCEVGLIV GTGTNACYME
     EMRHIDLVEG DEGRMCINME WGAFGDDGVL NDIRTEFDRE IDMGSLNPGK QLFEKMISGM
     YMGELVRLIL VKMAKEGLLF GGRLTPDLLT TGHFETRFVS AIEKEKEGLQ KAHEILSKLG
     LEPSHEDCLA TLRICQIVST RSASLCGATL AAVLRRIKDN KGVERLRSTV GVDGSVYKKH
     PHFARRLHKT VRKLLPDCEI RFIRSEDGSG KGAAMVTAVA YRLAAQHKAR QKILEPLKLS
     HEQLLEVKER MRIEMEKGLG KETHAEATVK MLPTYVCSTP DGTEKGDFLA LDLGGTNFRV
     LLVRVRNGMR RGVEMHNKIY SIPVEIMQGT GEELFDHIVH CISDFLEYMG MKGVSLPLGF
     TFSFPCQQNN LDEGILLKWT KGFKATGCEG EDVVGLLKEA IHRREEFDLD VVAVVNDTVG
     TMMTCGYEDP YCEVGLIVGT GSNACYMEEM RNVELVEGDE GRMCVNMEWG AFGDSGCLDD
     IRTEFDVAVD ELSLNPGKQR YEKMISGMYL GEIVRNILMD FTKKGLLFRG RISERLKTRG
     IFETKFLSQI ESDCLALLQV RSILQHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA
     VVDKIRENRG LDFLKITVGV DGTLYKLHPH FSNILHETVK QLSPKCEVTF LQSEDGSGKG
     AALITAVACR IREAGQR
//
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