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Database: UniProt/TrEMBL
Entry: W5P4S8_SHEEP
LinkDB: W5P4S8_SHEEP
Original site: W5P4S8_SHEEP 
ID   W5P4S8_SHEEP            Unreviewed;      2556 AA.
AC   W5P4S8;
DT   16-APR-2014, integrated into UniProtKB/TrEMBL.
DT   16-APR-2014, sequence version 1.
DT   28-MAR-2018, entry version 31.
DE   SubName: Full=SET domain containing 2 {ECO:0000313|Ensembl:ENSOARP00000005431};
GN   Name=SETD2 {ECO:0000313|Ensembl:ENSOARP00000005431};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000005431, ECO:0000313|Proteomes:UP000002356};
RN   [1] {ECO:0000313|Ensembl:ENSOARP00000005431, ECO:0000313|Proteomes:UP000002356}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000005431};
RX   PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
RA   Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
RA   Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
RA   Wang J., Wang W., Xun X.;
RT   "The sheep genome reference sequence: a work in progress.";
RL   Anim. Genet. 41:449-453(2010).
RN   [2] {ECO:0000313|Ensembl:ENSOARP00000005431}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2014) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY: S-adenosyl-L-methionine + L-lysine-[histone] =
CC       S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
CC       {ECO:0000256|SAAS:SAAS00591578}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00574581}.
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DR   EMBL; AMGL01045738; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011955535.1; XM_012100145.2.
DR   Ensembl; ENSOART00000005518; ENSOARP00000005431; ENSOARG00000005054.
DR   GeneID; 101114649; -.
DR   KEGG; oas:101114649; -.
DR   CTD; 29072; -.
DR   GeneTree; ENSGT00780000121845; -.
DR   KO; K11423; -.
DR   OMA; FIGHDSH; -.
DR   OrthoDB; EOG091G040P; -.
DR   Proteomes; UP000002356; Chromosome 19.
DR   GO; GO:0005694; C:chromosome; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043014; F:alpha-tubulin binding; IEA:Ensembl.
DR   GO; GO:0046975; F:histone methyltransferase activity (H3-K36 specific); IEA:Ensembl.
DR   GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR   GO; GO:0035441; P:cell migration involved in vasculogenesis; IEA:Ensembl.
DR   GO; GO:0060977; P:coronary vasculature morphogenesis; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
DR   GO; GO:0060669; P:embryonic placenta morphogenesis; IEA:Ensembl.
DR   GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR   GO; GO:0030900; P:forebrain development; IEA:Ensembl.
DR   GO; GO:0097676; P:histone H3-K36 dimethylation; IEA:Ensembl.
DR   GO; GO:0097198; P:histone H3-K36 trimethylation; IEA:Ensembl.
DR   GO; GO:0048332; P:mesoderm morphogenesis; IEA:Ensembl.
DR   GO; GO:1902850; P:microtubule cytoskeleton organization involved in mitosis; IEA:Ensembl.
DR   GO; GO:0006298; P:mismatch repair; IEA:Ensembl.
DR   GO; GO:0001763; P:morphogenesis of a branching structure; IEA:Ensembl.
DR   GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR   GO; GO:0034728; P:nucleosome organization; IEA:Ensembl.
DR   GO; GO:0018026; P:peptidyl-lysine monomethylation; IEA:Ensembl.
DR   GO; GO:0060039; P:pericardium development; IEA:Ensembl.
DR   GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR   GO; GO:0032465; P:regulation of cytokinesis; IEA:Ensembl.
DR   GO; GO:0010569; P:regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR   GO; GO:0010793; P:regulation of mRNA export from nucleus; IEA:Ensembl.
DR   GO; GO:1905634; P:regulation of protein localization to chromatin; IEA:Ensembl.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0034340; P:response to type I interferon; IEA:Ensembl.
DR   GO; GO:0048864; P:stem cell development; IEA:Ensembl.
DR   GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IEA:Ensembl.
DR   CDD; cd00201; WW; 1.
DR   Gene3D; 1.10.1740.100; -; 1.
DR   Gene3D; 1.20.930.10; -; 1.
DR   InterPro; IPR006560; AWS_dom.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR013257; SRI.
DR   InterPro; IPR038190; SRI_sf.
DR   InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   Pfam; PF00856; SET; 1.
DR   Pfam; PF08236; SRI; 1.
DR   Pfam; PF00397; WW; 1.
DR   SMART; SM00570; AWS; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SMART; SM00456; WW; 1.
DR   SUPFAM; SSF51045; SSF51045; 1.
DR   PROSITE; PS51215; AWS; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002356};
KW   Methyltransferase {ECO:0000256|SAAS:SAAS00590675};
KW   Nucleus {ECO:0000256|SAAS:SAAS00574642};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002356};
KW   S-adenosyl-L-methionine {ECO:0000256|SAAS:SAAS00591079};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00591533}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19   2556       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004868610.
FT   DOMAIN     1486   1540       AWS. {ECO:0000259|PROSITE:PS51215}.
FT   DOMAIN     1542   1659       SET. {ECO:0000259|PROSITE:PS50280}.
FT   DOMAIN     1666   1682       Post-SET. {ECO:0000259|PROSITE:PS50868}.
FT   DOMAIN     2381   2414       WW. {ECO:0000259|PROSITE:PS50020}.
FT   COILED     2114   2134       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2556 AA;  286295 MW;  6326A4B39B426853 CRC64;
     MIYFLFFCML SWLDDNREEE NEAKIENVPK TGFIKGPMFK GVASSRFLPK GTKTKVNLEE
     QGRQKVSFSF SLTKKTLQNR FLTALGNEKQ NDTPNSPVVP LQVDSTPKVK TDIGDTLSTT
     EESSPPKSRV ELGKIHFKKH LLHVTSRPLL TATTAVASLS PPMAPLPAVI AESTTVDSPP
     SSPPPPPPPP QATTPSSPAP VTEPVALPHT PVAVLMTAPV DVAARALKEP PVTVVPESSE
     VDTKQDLVSN SSEEHITHSL HEQADIPSQK EDSHIGKEEE TPDSSKSSLG SKKTGSKKKS
     SQSEGTFLGS ESDEDSVRTS SSQRSHDLKF SANIDRERDS KKSLATFKSE DLGKSSRSKT
     ERDDKYFSYS KLERDTRYIS SRCRERERRR SRSRSRSDRG SRTSLSYSRS ERSHYYDSDR
     RYHRSSPYRE RTRYSRAYTD SRARESSDSE DEYKKTYSRR TSSHSSSYRD LRTSSSYSKS
     DRDCKTESSY LEIEKRGKYS SKLERESKRT SENEAMKRCC SPPNELGFRR GSSYSKHDNN
     ASRYKSAPSK PVSKSDKFKN SFCCTELNEE TRQSHSFSLQ TPCSKGSELR VISKIPEREK
     TRSPSPSNRL NDSPTFKKLD GSPVFKSEFI GHDSHDSIKE VDSLCKVKND QLRSYCPTEL
     NINGSPGAES DLAAFCTSKH DTVLMSSDDS VTGSEVSPSV KTCMLSSNGF QNTNRFKEKD
     LDDTCMKHSK SESASRETEP LVSPHQDQLI SLPVITIDYS KTVVKEPVEV RVSCCKTKDS
     DIYCTSNDNH TSSCHSGAEN TEPLVSKMSS NSFMNVHLKS KTVICDNGNL TDQHSKFACG
     EYKQSVGSTS SASVNHFDDL YQTPGSSCIA SSLQSLPPGM KVNSLTLLQR GENISPVLDA
     VLKSKNSEFL KHAEKETVIE VGGDLPDSGR GFASWDSRHN NGLSEKCVQE AHEEGNSLLP
     DRRGRPEISL DEEGGRGHAH ISDDSEVVFS SCDLNLTMED SDGVTYTLKC DSSGHASEIV
     STVHEDYSGS SESSSDESDS EDTDSDDSSI PRNRLQSVVV VPKNSTLTME ETSPCSSRSS
     QSYRHYSDHW EDERLEPRRH SYEEKFESIT SKSCPQTEKF FFHKAAEKNS EISFIQPSRK
     QIDNHLPEIA HPQSDGVDST SHPDIKSDPL GHSNSEEMVK TKIASQQQEE LPVYSSDDFE
     DVSSKSRQQT AFPIRADSRL GKTDSSFSSS YEISRMDGVR SSEELRNLGW DFSQQEKPTS
     TYQQPDSSYG ACGGHKHQQS AEQCSGVRSY WQGNGYWDPR SASRPPGAGL VYDRVQGQVP
     DSLTDDREEE ENWDQRGGSH FSSQSSKFFL SLQKDKGSVQ APEISSNSIK DSLAVNEKKD
     LLKNLDRNDM KDRGPLKKRR QELESDSESD GELQDRKKVR VEIEQGETAV PLGSALVGPS
     CVMEDFRDPQ RWKEYAKQGK MPCYFDLIEE NVYLTERKKN KSHRDIKRMQ CECTPLSKDE
     RAQGEIACGE DCLNRLLMIE CSSRCPNGDY CSNRRFQRKQ HADVEVILTE KKGWGLRAAK
     DLPSNTFVLE YCGEVLDHKE FKARVKEYAR NKNIHYYFMA LKNDEIIDAT QKGNCSRFMN
     HSCEPNCETQ KWTVNGQLRV GFFTTKLVPS GSELTFDYQF QRYGKEAQKC FCGSANCRGY
     LGGENRVSIR AAGGKMKKER SRKKDSVDGE LEALMENGEG LSDKNQVLSL SRLMVRIETL
     EQKLTCLKLI QNTHSQSCLK SFLERHGLSL LWIWMAELGD GRESNQKLQE EIIKTLEHLP
     IPTKNMLEES KVLPIIQRWS QTKTAIPQLS EGDGYSSENT SRAHTPLNTP DPSTKLNAEA
     DTDTPKKLMF RRLKIISENS MDSAISDATS ELEGKDGKED LDQLENVPIE EEEEPQPQQL
     LVQQLPEPKV DSDIAAEASK LPTSELEADA EIEHKESSGA KLDEPIAEET PSQDEEEGVS
     DVESERSQEP PDKTVDISDL ATKLLDSWKD LKEVYRIPKK SQTEKESTIT ERGRDAVGFR
     DQTVAPKTPN RSRERDPDKQ TQIKEKRKRR GSLSPPSSAY ERGTKRPDDR YDTPTSKKKV
     RIKDRNKLST EERRKLFEQE VAQREAQKQQ QQMQNLGMTS PLPYDSLGYN APHHPFAGYP
     PGYPMQAYVD PSNPNAGKVL LPTPSMDPVC SPAAYDHSQP LVGHSTEPLA APPPVPVVPH
     VAAPVEVSSS QYVAQSDAVV HQDSSVTVLP VPAPGPVQGQ NYSVWDSNQQ SVSVQQQYSP
     AQSQATIYYQ GQACPTVYGV TSPYSQTTPP IVQSYAQPSL QYIQGQQIFT AHPQGVVVQP
     TAAVTTIVAP GQPQPLQPPE MVVANNLLDL PPPSPPKPKT IVLPPNWKTA RDPEGKIYYY
     HVVTRQTQWD PPTWESPGDD ASLEHEAEMD LGTPTYDENP MKTSKKPKTA EADTSSELAK
     KSKEVFRKEM SQFIVQCLNP YRKPDCKVGR ITTTEDFKHL ARKLTHGVMN KELKYCKNPE
     DLECNENVKH KTKEYIKKYM QKFGAVYKPK EDTELE
//
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