KEGG   Tupaia chinensis (Chinese tree shrew): 102472233
Entry
102472233         CDS       T02978                                 
Symbol
MAPK8
Name
(RefSeq) mitogen-activated protein kinase 8
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
tup  Tupaia chinensis (Chinese tree shrew)
Pathway
tup01522  Endocrine resistance
tup04010  MAPK signaling pathway
tup04012  ErbB signaling pathway
tup04014  Ras signaling pathway
tup04024  cAMP signaling pathway
tup04068  FoxO signaling pathway
tup04071  Sphingolipid signaling pathway
tup04137  Mitophagy - animal
tup04140  Autophagy - animal
tup04141  Protein processing in endoplasmic reticulum
tup04210  Apoptosis
tup04215  Apoptosis - multiple species
tup04217  Necroptosis
tup04310  Wnt signaling pathway
tup04380  Osteoclast differentiation
tup04510  Focal adhesion
tup04530  Tight junction
tup04620  Toll-like receptor signaling pathway
tup04621  NOD-like receptor signaling pathway
tup04622  RIG-I-like receptor signaling pathway
tup04625  C-type lectin receptor signaling pathway
tup04657  IL-17 signaling pathway
tup04658  Th1 and Th2 cell differentiation
tup04659  Th17 cell differentiation
tup04660  T cell receptor signaling pathway
tup04664  Fc epsilon RI signaling pathway
tup04668  TNF signaling pathway
tup04722  Neurotrophin signaling pathway
tup04723  Retrograde endocannabinoid signaling
tup04728  Dopaminergic synapse
tup04750  Inflammatory mediator regulation of TRP channels
tup04910  Insulin signaling pathway
tup04912  GnRH signaling pathway
tup04914  Progesterone-mediated oocyte maturation
tup04917  Prolactin signaling pathway
tup04920  Adipocytokine signaling pathway
tup04926  Relaxin signaling pathway
tup04930  Type II diabetes mellitus
tup04931  Insulin resistance
tup04932  Non-alcoholic fatty liver disease
tup04933  AGE-RAGE signaling pathway in diabetic complications
tup04935  Growth hormone synthesis, secretion and action
tup04936  Alcoholic liver disease
tup05010  Alzheimer disease
tup05012  Parkinson disease
tup05016  Huntington disease
tup05017  Spinocerebellar ataxia
tup05020  Prion disease
tup05022  Pathways of neurodegeneration - multiple diseases
tup05132  Salmonella infection
tup05133  Pertussis
tup05135  Yersinia infection
tup05142  Chagas disease
tup05145  Toxoplasmosis
tup05152  Tuberculosis
tup05161  Hepatitis B
tup05162  Measles
tup05166  Human T-cell leukemia virus 1 infection
tup05167  Kaposi sarcoma-associated herpesvirus infection
tup05169  Epstein-Barr virus infection
tup05170  Human immunodeficiency virus 1 infection
tup05171  Coronavirus disease - COVID-19
tup05200  Pathways in cancer
tup05208  Chemical carcinogenesis - reactive oxygen species
tup05210  Colorectal cancer
tup05212  Pancreatic cancer
tup05231  Choline metabolism in cancer
tup05415  Diabetic cardiomyopathy
tup05417  Lipid and atherosclerosis
tup05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:tup00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    102472233 (MAPK8)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102472233 (MAPK8)
   04012 ErbB signaling pathway
    102472233 (MAPK8)
   04014 Ras signaling pathway
    102472233 (MAPK8)
   04310 Wnt signaling pathway
    102472233 (MAPK8)
   04668 TNF signaling pathway
    102472233 (MAPK8)
   04068 FoxO signaling pathway
    102472233 (MAPK8)
   04071 Sphingolipid signaling pathway
    102472233 (MAPK8)
   04024 cAMP signaling pathway
    102472233 (MAPK8)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102472233 (MAPK8)
   04137 Mitophagy - animal
    102472233 (MAPK8)
  09143 Cell growth and death
   04210 Apoptosis
    102472233 (MAPK8)
   04215 Apoptosis - multiple species
    102472233 (MAPK8)
   04217 Necroptosis
    102472233 (MAPK8)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102472233 (MAPK8)
   04530 Tight junction
    102472233 (MAPK8)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    102472233 (MAPK8)
   04621 NOD-like receptor signaling pathway
    102472233 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    102472233 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    102472233 (MAPK8)
   04660 T cell receptor signaling pathway
    102472233 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    102472233 (MAPK8)
   04659 Th17 cell differentiation
    102472233 (MAPK8)
   04657 IL-17 signaling pathway
    102472233 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    102472233 (MAPK8)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102472233 (MAPK8)
   04920 Adipocytokine signaling pathway
    102472233 (MAPK8)
   04912 GnRH signaling pathway
    102472233 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    102472233 (MAPK8)
   04917 Prolactin signaling pathway
    102472233 (MAPK8)
   04926 Relaxin signaling pathway
    102472233 (MAPK8)
   04935 Growth hormone synthesis, secretion and action
    102472233 (MAPK8)
  09156 Nervous system
   04728 Dopaminergic synapse
    102472233 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    102472233 (MAPK8)
   04722 Neurotrophin signaling pathway
    102472233 (MAPK8)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    102472233 (MAPK8)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102472233 (MAPK8)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102472233 (MAPK8)
   05208 Chemical carcinogenesis - reactive oxygen species
    102472233 (MAPK8)
   05231 Choline metabolism in cancer
    102472233 (MAPK8)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102472233 (MAPK8)
   05212 Pancreatic cancer
    102472233 (MAPK8)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102472233 (MAPK8)
   05170 Human immunodeficiency virus 1 infection
    102472233 (MAPK8)
   05161 Hepatitis B
    102472233 (MAPK8)
   05171 Coronavirus disease - COVID-19
    102472233 (MAPK8)
   05162 Measles
    102472233 (MAPK8)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102472233 (MAPK8)
   05169 Epstein-Barr virus infection
    102472233 (MAPK8)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102472233 (MAPK8)
   05135 Yersinia infection
    102472233 (MAPK8)
   05133 Pertussis
    102472233 (MAPK8)
   05152 Tuberculosis
    102472233 (MAPK8)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102472233 (MAPK8)
   05142 Chagas disease
    102472233 (MAPK8)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102472233 (MAPK8)
   05012 Parkinson disease
    102472233 (MAPK8)
   05016 Huntington disease
    102472233 (MAPK8)
   05017 Spinocerebellar ataxia
    102472233 (MAPK8)
   05020 Prion disease
    102472233 (MAPK8)
   05022 Pathways of neurodegeneration - multiple diseases
    102472233 (MAPK8)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102472233 (MAPK8)
   05418 Fluid shear stress and atherosclerosis
    102472233 (MAPK8)
   05415 Diabetic cardiomyopathy
    102472233 (MAPK8)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    102472233 (MAPK8)
   04936 Alcoholic liver disease
    102472233 (MAPK8)
   04932 Non-alcoholic fatty liver disease
    102472233 (MAPK8)
   04931 Insulin resistance
    102472233 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102472233 (MAPK8)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    102472233 (MAPK8)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:tup01001]
    102472233 (MAPK8)
Enzymes [BR:tup01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     102472233 (MAPK8)
Protein kinases [BR:tup01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   102472233 (MAPK8)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Kdo ABC1 RIO1 Kinase-like FTA2 APH
Other DBs
NCBI-GeneID: 102472233
NCBI-ProteinID: XP_006147787
Position
Un
AA seq 427 aa
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVTSGPQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt   +upstreamnt  +downstreamnt
atgagcagaagcaaacgtgacaacaatttttatagtgtagagatcggagattctacattc
acagtcctgaaacgatatcagaacctaaaacctataggctctggagcgcaaggaatagta
tgcgcagcttatgatgccatccttgaaagaaatgttgcaatcaagaagctaagccgacca
tttcagaatcaaacacatgctaagcgggcctacagagagctagtccttatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaagtccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggagctggatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctgggattattcatcgggacttaaagcccagcaacatagtagtaaag
tcagactgcactttgaagatccttgacttcgggctggccaggacagcggggaccagcttc
atgatgacgccttacgtagtgactcgctactaccgagcgcccgaggtcatcctcggcatg
ggctacaaggagaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttattgagcag
cttggaacaccatgtcctgaattcatgaagaaactgcagccaacagtaaggacttacgtt
gaaaacagacctaagtatgcgggctatagcttcgagaagctcttccctgacgtacttttc
ccagctgactcagagcacaacaaacttaaagccagtcaggcaagagatttactatccaaa
atgctggtaatagatgcgtctaaaaggatctctgtagacgaagctctccagcacccgtat
atcaatgtctggtatgacccttccgaagcagaagctccaccaccaaagatacctgacaag
cagttagatgaaagggaacacacgatagaagagtggaaagaattgatatacaaggaagtg
atggacttggaggagagaaccaagaacggagttatacgggggcagccttctcctttaggt
gcagcagtgaccagcggccctcagcacccgtcgtcgtcctcgtctgtcaatgatgtgtcc
tcaatgtcgacagatccgaccttggcctcggatacggacagcagtctggaagcatccgcc
ggacctctgggctgctgtagatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (70)   
   KEGG PATHWAY (70)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   RefSeq(pep) (3)   
DNA sequence (7)   
   RefSeq(nuc) (3)   
   GenBank (2)   
   EMBL (2)   
Protein domain (8)   
   Pfam (8)   
All databases (103)   

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