KEGG   Ursus arctos horribilis (North American brown bear): 113260929
Entry
113260929         CDS       T05909                                 
Symbol
PRKAA1
Name
(RefSeq) 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1
  KO
K07198  5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
Organism
uah  Ursus arctos horribilis (North American brown bear)
Pathway
uah04068  FoxO signaling pathway
uah04140  Autophagy - animal
uah04150  mTOR signaling pathway
uah04151  PI3K-Akt signaling pathway
uah04152  AMPK signaling pathway
uah04211  Longevity regulating pathway
uah04213  Longevity regulating pathway - multiple species
uah04371  Apelin signaling pathway
uah04530  Tight junction
uah04710  Circadian rhythm
uah04714  Thermogenesis
uah04910  Insulin signaling pathway
uah04920  Adipocytokine signaling pathway
uah04921  Oxytocin signaling pathway
uah04922  Glucagon signaling pathway
uah04931  Insulin resistance
uah04932  Non-alcoholic fatty liver disease
uah04936  Alcoholic liver disease
uah05410  Hypertrophic cardiomyopathy
uah05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:uah00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    113260929 (PRKAA1)
   04068 FoxO signaling pathway
    113260929 (PRKAA1)
   04151 PI3K-Akt signaling pathway
    113260929 (PRKAA1)
   04152 AMPK signaling pathway
    113260929 (PRKAA1)
   04150 mTOR signaling pathway
    113260929 (PRKAA1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    113260929 (PRKAA1)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    113260929 (PRKAA1)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    113260929 (PRKAA1)
   04922 Glucagon signaling pathway
    113260929 (PRKAA1)
   04920 Adipocytokine signaling pathway
    113260929 (PRKAA1)
   04921 Oxytocin signaling pathway
    113260929 (PRKAA1)
  09149 Aging
   04211 Longevity regulating pathway
    113260929 (PRKAA1)
   04213 Longevity regulating pathway - multiple species
    113260929 (PRKAA1)
  09159 Environmental adaptation
   04710 Circadian rhythm
    113260929 (PRKAA1)
   04714 Thermogenesis
    113260929 (PRKAA1)
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    113260929 (PRKAA1)
   05410 Hypertrophic cardiomyopathy
    113260929 (PRKAA1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    113260929 (PRKAA1)
   04932 Non-alcoholic fatty liver disease
    113260929 (PRKAA1)
   04931 Insulin resistance
    113260929 (PRKAA1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:uah01001]
    113260929 (PRKAA1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:uah04131]
    113260929 (PRKAA1)
   03029 Mitochondrial biogenesis [BR:uah03029]
    113260929 (PRKAA1)
Enzymes [BR:uah01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.31  [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
     113260929 (PRKAA1)
Protein kinases [BR:uah01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   113260929 (PRKAA1)
Membrane trafficking [BR:uah04131]
 Autophagy
  Other autophagy associated proteins
   Others
    113260929 (PRKAA1)
Mitochondrial biogenesis [BR:uah03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    113260929 (PRKAA1)
  Mitophagy factors
   Other mitophagy factors
    113260929 (PRKAA1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr AMPK_alpha_AID AdenylateSensor Kinase-like ABC1 FTA2 Kdo
Other DBs
NCBI-GeneID: 113260929
NCBI-ProteinID: XP_026362659
Position
Unknown
AA seq 574 aa
MRRLSSWRKMATAEKQKHDGRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR
QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDIFMVMEYVSGGELFDYICKNG
RKSDVPGVVRTGSMKELDEKESRRLFQQILSGVDYCHRHMVVHRDLKPENVLLDAHMNAK
IADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLCGTLPF
DDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRATIKDIREHEWFKQDLPK
YLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDNRRIM
NEAKDFYLATSPPDSFLDDHHFTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKA
KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQV
DSRTYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRNDSDAEAQGKSSEASLTSSV
TSLDSSPVDLTPRPGSHTIEFFEMCANLIKILAQ
NT seq 1725 nt   +upstreamnt  +downstreamnt
atgcgcagactcagttcctggagaaagatggcgacagccgagaagcagaaacacgacggg
cgggtgaagatcggccactacatcctgggggacacccttggcgtcggcaccttcggcaaa
gtgaaggttggcaaacatgaattgactggacataaagttgctgtgaagatactcaatcga
cagaagattcgaagccttgatgtggtaggaaaaatccgcagagaaattcagaacctcaag
cttttcaggcatcctcatataattaaactgtaccaggtcatcagtacaccatctgatatt
ttcatggtgatggaatatgtctcaggaggagagctatttgattatatctgtaaaaatgga
aggaaatctgatgtacctggagtagtaagaacaggctccatgaaggagctggatgagaaa
gaaagtcggcgtctgtttcaacagatcctttctggtgtggattactgtcacaggcatatg
gtggtccatagagatctgaaacctgaaaatgtcctgcttgatgcacacatgaatgcaaag
atagctgattttggtctttcaaacatgatgtcagatggtgaattcttaagaacaagttgc
ggctcacccaactatgctgcaccagaagtaatttcaggaagattgtatgcaggtccagag
gtagatatatggagcagtggggttattctctatgctttattatgtggaacccttccattt
gatgatgatcatgtgccaactctttttaagaagatatgtgatgggatcttttatacccct
cagtatttaaatccgtctgtgattagccttttgaaacatatgctacaggtggatcccatg
aagagggccacaatcaaagatatcagggaacatgaatggtttaaacaagatcttccaaaa
tatctttttcccgaggatccatcatacagttcaaccatgattgatgatgaagccttaaaa
gaagtatgtgaaaaatttgagtgctcagaagaggaggttctgagctgcctttataacaga
aatcaccaggaccctttggcagttgcctaccacctcataatagataacaggagaataatg
aatgaggccaaagatttttacttggcgacaagcccacctgattcttttctcgatgatcac
cacttcactcggccccatcctgaaagagtaccattcttggttgctgaaacaccaagagca
cgccacaccctcgatgaattaaatccacagaaatccaaacaccaaggtgtaaggaaagca
aaatggcatttgggaattagaagtcaaagtcgaccgaatgatatcatggcagaagtttgt
agagcaattaaacagctggattatgaatggaaggttgtaaacccctattatttgcgtgtt
cgaaggaagaatcctgtgacaagtacatactccaaaatgagtctgcagttataccaagtg
gatagtagaacatacttactggatttccgtagtattgatgatgaaattactgaagccaaa
tcagggactgctactccacagagatcgggatcagtaagcaactatcgatcttgccaaagg
aatgattcagatgctgaggctcaaggaaaatcctcagaagcttctcttacctcatctgtg
acctcacttgactcttctcctgttgacttaacaccaagacctggaagtcacacaatagaa
ttttttgagatgtgtgcaaatctaattaaaattcttgcacagtaa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
Protein sequence (7)   
   RefSeq(pep) (7)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (8)   
   Pfam (8)   
All databases (52)   

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