KEGG   Ursus maritimus (polar bear): 103661560
Entry
103661560         CDS       T03271                                 
Symbol
ERBB2
Name
(RefSeq) receptor tyrosine-protein kinase erbB-2
  KO
K05083  receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr01521  EGFR tyrosine kinase inhibitor resistance
umr01522  Endocrine resistance
umr01524  Platinum drug resistance
umr04010  MAPK signaling pathway
umr04012  ErbB signaling pathway
umr04020  Calcium signaling pathway
umr04066  HIF-1 signaling pathway
umr04151  PI3K-Akt signaling pathway
umr04510  Focal adhesion
umr04520  Adherens junction
umr04530  Tight junction
umr05200  Pathways in cancer
umr05205  Proteoglycans in cancer
umr05206  MicroRNAs in cancer
umr05212  Pancreatic cancer
umr05213  Endometrial cancer
umr05215  Prostate cancer
umr05219  Bladder cancer
umr05223  Non-small cell lung cancer
umr05224  Breast cancer
umr05226  Gastric cancer
umr05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103661560 (ERBB2)
   04012 ErbB signaling pathway
    103661560 (ERBB2)
   04066 HIF-1 signaling pathway
    103661560 (ERBB2)
   04020 Calcium signaling pathway
    103661560 (ERBB2)
   04151 PI3K-Akt signaling pathway
    103661560 (ERBB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103661560 (ERBB2)
   04520 Adherens junction
    103661560 (ERBB2)
   04530 Tight junction
    103661560 (ERBB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103661560 (ERBB2)
   05206 MicroRNAs in cancer
    103661560 (ERBB2)
   05205 Proteoglycans in cancer
    103661560 (ERBB2)
   05230 Central carbon metabolism in cancer
    103661560 (ERBB2)
  09162 Cancer: specific types
   05212 Pancreatic cancer
    103661560 (ERBB2)
   05226 Gastric cancer
    103661560 (ERBB2)
   05219 Bladder cancer
    103661560 (ERBB2)
   05215 Prostate cancer
    103661560 (ERBB2)
   05213 Endometrial cancer
    103661560 (ERBB2)
   05224 Breast cancer
    103661560 (ERBB2)
   05223 Non-small cell lung cancer
    103661560 (ERBB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103661560 (ERBB2)
   01524 Platinum drug resistance
    103661560 (ERBB2)
   01522 Endocrine resistance
    103661560 (ERBB2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:umr01001]
    103661560 (ERBB2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:umr04147]
    103661560 (ERBB2)
   04090 CD molecules [BR:umr04090]
    103661560 (ERBB2)
Enzymes [BR:umr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     103661560 (ERBB2)
Protein kinases [BR:umr01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   103661560 (ERBB2)
Exosome [BR:umr04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   103661560 (ERBB2)
CD molecules [BR:umr04090]
 Proteins
  103661560 (ERBB2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Haspin_kinase Kinase-like APH
Other DBs
NCBI-GeneID: 103661560
NCBI-ProteinID: XP_040496620
UniProt: A0A8M1GNK5
Position
Unknown
AA seq 1260 aa
MELAAWCRWGLLLALLPSGAAGTQVCTGTDMKLRLPASPETHLDMLRHLYQACQVVQGNL
ELTYLPANASLSFLQDIQEVQGYVLIAHSQVRQVPLQRLRIVRGTQLFEDNYALAVLDNG
EPPEGDTSVAGATPGGLRELQLRSLTEILKGGVLIQRNPRLCHQDTILWKDIFHKNNQLA
LTLIDTNRSRACQPCSPACKDPHCWGASSGDCQSLTRTVCAGGCARCKGPKPTDCCHEQC
AAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACP
YNYLSTDVGSCTLVCPLNNQEVTAEDGTQRCEKCSRPCARVCYGLGMEHLREARAVTSAN
IQEFAGCKKIFGSLAFLPESFEGDPASNTAPLQPEQLRVFEALEEITGYLYISAWPDSLP
NLSVFQNLRVIRGRVLHDGAYSLTLQGLGISWLGLRSLRELGSGLALIHRNARLCFIHTV
PWEQLFRNPHQALLHSANRPEAECVGEGLACYPLCAHGHCWGPGPTQCVNCSQFLRGQEC
VEECRELHGLPREYVKDRYCLPCHPECRPQNGSVTCFGSEADQCVACAHYKDPPSCVARC
PSGVKPDLSFMPIWKFADEEGTCQPCPINCTHSCGDLDERGCPAEQRASPVTSIIAAVVG
ILLAVVMGLVLGILIKRRRQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETEL
RKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSP
YVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVR
LVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFT
HQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWM
IDSECRPRFRELVAEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDA
EEYLVPQQGFFCPEPAPGAGGPAHCRHRSSSTRSGGGELTVGLEPSEEEPPKSPLAPSEG
AGSDMFDGDLGMGAAKGLQSLPPQDPSPLQRYSEDPTVPLPPETDGYVAPLTSSPQPEYV
NQPEVWPQPPSPLEGPLPPPRPAGATLERPKTLSPKTLSPGKNGVIKDVFAFGSAVENPE
YLAPRGRAAPQLHPPPAFSPAFDNLYYWDQDPSERGSPPSTFEGTPTAENPEYLGLDVPV
NT seq 3783 nt   +upstreamnt  +downstreamnt
atggagctggcggcctggtgccgctgggggctcctcctcgccctcctgccctccggagcc
gcgggcacccaagtgtgcaccggcacagacatgaagctgcggctccctgccagtcccgag
acccacctggatatgctccgccacctctaccaggcctgtcaagtggtacagggtaacctg
gagctcacctacctgcccgccaatgccagcctgtccttcctgcaggatatccaggaggta
cagggctatgtgctcattgctcacagccaagtgagacaggtcccgctgcagaggctccga
atcgtgcgaggcacccagctctttgaggacaactacgccctggccgtgctggacaatgga
gagccgcccgagggggacacctctgtggcaggggctaccccaggagggctgcgggagctg
cagcttcgaagcctcacagagatcctgaagggaggggtcttgattcagcggaacccacgg
ctctgccaccaggacacgattttgtggaaggacatcttccacaagaacaaccagctggcc
ctcacgctgatagacaccaaccgctctcgggcctgccaaccctgttctccagcctgtaaa
gacccccactgctggggagcaagttccggggactgtcagagcttgacacgaaccgtctgt
gccggcggctgtgcccgctgcaagggcccaaaacccactgactgctgccacgagcagtgc
gcggctggctgcacgggccccaagcactcggactgcctggcctgccttcacttcaaccac
agtggcatctgtgagctgcactgcccagccctggtcacctacaacacggacacgttcgaa
tccatgcccaaccctgagggccgatacaccttcggtgccagctgtgtgaccgcctgtccc
tacaactacctgtccacggacgtgggatcctgcaccctggtctgtcccctgaacaaccaa
gaggtgacggctgaggatggcacccagcggtgtgagaaatgcagcagaccctgtgcccga
gtgtgctatggtctgggcatggagcacctgcgggaggcgagggcggtcaccagcgccaac
atccaagaattcgccggctgcaagaagatctttgggagcctggcgtttctgccagagagc
ttcgagggagacccagcctccaacactgcccccctgcagcctgaacagctcagagtgttc
gaggccctggaggagatcacaggttacctgtatatctcagcgtggccggacagcttgcct
aacctcagtgtcttccagaacctgcgagtaatccggggacgagttctgcatgatggcgcc
tactcgctgaccctgcaagggctgggcatcagctggctggggctgcgctcgctgcgggaa
ctgggcagcgggctggccctcatccaccgcaacgcccgcctctgcttcatccacacggtg
ccctgggagcagctcttccggaacccccaccaagccctgctgcacagtgccaaccggccg
gaggccgagtgcgtgggcgagggcctggcctgctacccgctgtgcgcccatgggcactgc
tggggtccggggcccacccagtgcgtcaactgcagccaattccttcggggccaggagtgc
gtggaggaatgccgagaactgcacgggctaccccgggaatatgtgaaggacagatactgt
ctgccatgccaccccgagtgtcggccccagaatggctcagtgacctgctttgggtcggag
gctgaccagtgtgtggcctgcgcccactacaaggaccctccctcctgcgtggctcgctgc
cccagtggtgtgaaacccgacctctctttcatgcccatttggaagtttgcagatgaggag
ggcacatgccagccgtgccccatcaactgcacccactcctgtggggacctggacgagagg
ggctgccccgccgaacagagagccagccctgtgacatccatcattgccgctgtggtgggc
attctgctggccgtggtcatggggctggtcctcggcatcctgatcaagcgaaggcgacag
aagatccgcaagtacacgatgcggaggttgctgcaggaaaccgagctggtggagccgctg
acgcctagcggagcgatgcccaaccaggctcagatgcggatcctgaaagagacagagctg
aggaaggtgaaggtgcttggatccggagcttttggcacggtctacaagggcatctggatc
cctgacggggaaaatgtgaaaatcccagtggccatcaaagtgttgagggaaaacacatct
cccaaagccaacaaagaaatcttggacgaagcatatgtgatggctggagtgggctcccca
tatgtgtcccgccttctgggcatctgcctgacgtccacggtgcagctggtgacacagctt
atgccctatggctgcctcttagaccacgtccgagagcaccgtgggcgtctgggctcccag
gacctcctgaactggtgtgtgcagatcgccaaggggatgagctacttggaggacgtccgg
ctcgtgcacagggacctggctgcccggaacgtgctggtcaagagtcccaaccatgtcaag
attacagacttcgggctggctcggttgctggacattgatgagaccgagtaccacgcggat
gggggcaaggtgcccatcaagtggatggcgctggagtccattctccgccggcggttcacc
caccagagtgacgtgtggagctacggtgtgactgtgtgggaactgatgacttttggggcc
aaaccttacgatgggatcccagcccgagagatccctgacctgctggagaagggggaacgg
ctgccccagccccccatctgcaccatcgacgtctacatgattatggttaaatgttggatg
atagactctgaatgtcgaccacggttccgggagttggtggccgaattctcccgtatggcc
agggacccccagcgctttgtggtcatccagaatgaagacctgggccccgccagcccattg
gacagcaccttctaccgttcgctgctggaagatgatgacatgggggacctggtggatgcc
gaggagtacctggtgccccagcaggggttcttctgcccagaacctgcccctggagcgggg
ggcccggcccactgcaggcaccgcagctcgtccaccaggagtggcggtggtgagctgaca
gtgggactggagccctctgaggaggagccccccaagtctccactggccccgtcagagggg
gctggctctgacatgtttgatggtgacttgggaatgggggcagccaaggggctgcagagc
cttcccccccaggacccgagccctctacagcggtacagcgaggaccctacagtacccctg
ccccctgagactgatggctacgttgcccccctgaccagcagccctcagcctgaatacgtg
aaccagccagaggtttggccgcagcccccctcacccctagaaggccctctgcctcctcct
cgacctgctggtgccaccctggaaaggcccaagactctgtcccccaagaccctctcccct
ggcaagaatggggtcatcaaagacgtttttgcctttgggagtgcggtggagaaccctgag
tacttggcaccccggggcagggctgcccctcagctccaccctcctccagccttcagccca
gcctttgacaacctctattactgggaccaggacccatcagagcggggctctccacccagt
acctttgaagggacccctacagcagagaaccctgagtacctgggcctggacgtgccagtg
tga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (22)   
   KEGG PATHWAY (22)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
Protein domain (9)   
   Pfam (9)   
All databases (47)   

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