KEGG   Ursus maritimus (polar bear): 103667762
Entry
103667762         CDS       T03271                                 
Symbol
SIRT1
Name
(RefSeq) NAD-dependent protein deacetylase sirtuin-1 isoform X2
  KO
K11411  NAD-dependent protein deacetylase sirtuin 1 [EC:2.3.1.286]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00760  Nicotinate and nicotinamide metabolism
umr01100  Metabolic pathways
umr04068  FoxO signaling pathway
umr04148  Efferocytosis
umr04152  AMPK signaling pathway
umr04211  Longevity regulating pathway
umr04213  Longevity regulating pathway - multiple species
umr04218  Cellular senescence
umr04310  Wnt signaling pathway
umr04922  Glucagon signaling pathway
umr04936  Alcoholic liver disease
umr05031  Amphetamine addiction
umr05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    103667762 (SIRT1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    103667762 (SIRT1)
   04068 FoxO signaling pathway
    103667762 (SIRT1)
   04152 AMPK signaling pathway
    103667762 (SIRT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    103667762 (SIRT1)
  09143 Cell growth and death
   04218 Cellular senescence
    103667762 (SIRT1)
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    103667762 (SIRT1)
  09149 Aging
   04211 Longevity regulating pathway
    103667762 (SIRT1)
   04213 Longevity regulating pathway - multiple species
    103667762 (SIRT1)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    103667762 (SIRT1)
  09165 Substance dependence
   05031 Amphetamine addiction
    103667762 (SIRT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    103667762 (SIRT1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:umr03036]
    103667762 (SIRT1)
   03029 Mitochondrial biogenesis [BR:umr03029]
    103667762 (SIRT1)
Enzymes [BR:umr01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     103667762 (SIRT1)
Chromosome and associated proteins [BR:umr03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     103667762 (SIRT1)
Mitochondrial biogenesis [BR:umr03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    103667762 (SIRT1)
SSDB
Motif
Pfam: SIR2
Other DBs
NCBI-GeneID: 103667762
NCBI-ProteinID: XP_008694159
UniProt: A0A384CI62
Position
Unknown
AA seq 446 aa
MCLCSGRKTILEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCH
GSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFH
RAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCD
VIINELCHRLGGEYAKLCCNPVKLSEISEKPPRTQKELAHLSELPPTPLNISEDSSSPER
TSPPDSSVIVTLLDQAPKSNVDDPGVSKSKDCMEEKSQEGQNSTRNIESVTEQLESPDLK
NVGSNTGEKNERTSVADTVRKCWPARLAKEQISKRLDGNQYLFLPPNRYIFHGAEVYSDS
EDDVLSSSSCGSNSDSGTCQSPSVEEHLEDESEIEEFYNGLEDEADVNERAGGTGFGIGG
GDHEAGSEAISMKQEVTDINYPSNKS
NT seq 1341 nt   +upstreamnt  +downstreamnt
atgtgcctgtgcagtggaaggaaaacaattttggaaatatatcctggacagttccaacca
tctctctgtcacaaattcatagccttgtcagataaagaaggaaaactacttcggaactat
actcagaacatagatacactggaacaggttgcaggaatccaaaggataattcaatgtcat
ggttcctttgcaacagcatcttgcctgatttgtaaatacaaagtagactgtgaagctgta
cgaggagatatttttaatcaggtggttcctcgttgtcctaggtgcccagctgatgagcca
cttgctatcatgaaaccagagatagtcttttttggtgaaaatttaccagagcagtttcat
agagccatgaagtatgacaaagatgaagttgatctcctcattgttattgggtcttccctg
aaagtaagaccagtagcactaattccaagttccataccccatgaagtgcctcagatatta
ataaatagagaacctttgcctcatctgcattttgatgtagagcttcttggagactgtgat
gtcataataaatgaattatgccataggttaggtggtgaatatgccaaactttgctgcaac
cctgtaaagctttcagaaattagtgaaaaacctccacgaacacaaaaagagttggctcat
ttgtcagagttgccacccacacctcttaatatttcagaagactcaagttcaccggaaaga
acttcaccacctgattcttcagtgattgttacacttttagaccaagcacctaagagtaat
gttgatgatcctggtgtgtccaaatcaaaagattgtatggaagaaaagtcacaggaagga
cagaattctactaggaacattgaaagtgttactgaacagttggaaagtccggatttgaag
aatgttggctctaacactggggagaaaaatgaaagaacttcagttgctgacacagtgagg
aagtgctggccagctagacttgcaaaggagcaaattagcaaacggcttgatggtaaccag
tatctgttcttaccaccaaatcgttatattttccatggcgctgaggtatattcggactct
gaagatgacgtcttatcctctagttcttgtggtagtaacagtgatagtggaacgtgccag
agtccaagtgtagaagaacacttggaggatgaaagtgagattgaagaattttacaatggt
ttggaagatgaagctgatgttaatgagagagctggaggaactggatttggaattggtgga
ggtgatcatgaggcaggcagtgaagctatatccatgaaacaggaagtaacagacattaac
tatccatcaaacaaatcataa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (13)   
   KEGG PATHWAY (13)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (1)   
   Pfam (1)   
All databases (40)   

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