KEGG   Ursus maritimus (polar bear): 103670323
Entry
103670323         CDS       T03271                                 
Symbol
HSPA5
Name
(RefSeq) endoplasmic reticulum chaperone BiP
  KO
K09490  endoplasmic reticulum chaperone BiP [EC:3.6.4.10]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr03060  Protein export
umr04141  Protein processing in endoplasmic reticulum
umr04612  Antigen processing and presentation
umr04918  Thyroid hormone synthesis
umr05012  Parkinson disease
umr05014  Amyotrophic lateral sclerosis
umr05020  Prion disease
umr05022  Pathways of neurodegeneration - multiple diseases
umr05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:umr00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03060 Protein export
    103670323 (HSPA5)
   04141 Protein processing in endoplasmic reticulum
    103670323 (HSPA5)
 09150 Organismal Systems
  09151 Immune system
   04612 Antigen processing and presentation
    103670323 (HSPA5)
  09152 Endocrine system
   04918 Thyroid hormone synthesis
    103670323 (HSPA5)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    103670323 (HSPA5)
   05014 Amyotrophic lateral sclerosis
    103670323 (HSPA5)
   05020 Prion disease
    103670323 (HSPA5)
   05022 Pathways of neurodegeneration - multiple diseases
    103670323 (HSPA5)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103670323 (HSPA5)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts [BR:umr03110]
    103670323 (HSPA5)
   04131 Membrane trafficking [BR:umr04131]
    103670323 (HSPA5)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:umr04147]
    103670323 (HSPA5)
Enzymes [BR:umr01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.4  Acting on acid anhydrides to facilitate cellular and subcellular movement
    3.6.4.10  non-chaperonin molecular chaperone ATPase
     103670323 (HSPA5)
Chaperones and folding catalysts [BR:umr03110]
 Heat shock proteins
  HSP70 / DNAK
   103670323 (HSPA5)
Membrane trafficking [BR:umr04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   ER-Golgi intermediate compartment (ERGIC) proteins
    103670323 (HSPA5)
Exosome [BR:umr04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   103670323 (HSPA5)
  Exosomal proteins of other body fluids (saliva and urine)
   103670323 (HSPA5)
  Exosomal proteins of colorectal cancer cells
   103670323 (HSPA5)
SSDB
Motif
Pfam: HSP70 MreB_Mbl Hydantoinase_A FtsA DDR FGGY_C ParM_N Tombus_movement
Other DBs
NCBI-GeneID: 103670323
NCBI-ProteinID: XP_008696995
UniProt: A0A384CR94
Position
Unknown
AA seq 654 aa
MKLSLVAAVLLLLGAARAEEEDKKEDVGTVVGIDLGTTYSCVGVFKNGRVEIIANDQGNR
ITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDAKRLIGRTWNDPSVQQDIKFLPFKVV
EKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAYLGKKVTHAVVTVPAYFNDAQ
RQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKREGEKNILVFDLGGGTFDVSLLTIDNG
VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKLRREVEKAKRALS
SQHQARIEIESFYEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKKSDIDEIV
LVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLSGDQDTGDLVLLDVC
PLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLG
TFDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIER
MVNDAEKFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEE
KIEWLESHQDADIEDFKAKKKELEEIVQPIISKLYGSAGPPPTGDEEPADKDEL
NT seq 1965 nt   +upstreamnt  +downstreamnt
atgaagctgtccctggtggctgcggtgctgctgctcctcggcgcggcgcgggccgaggag
gaggacaagaaggaggacgtgggcacggtggtcggcatcgacttggggaccacctactcc
tgcgtcggggtgttcaagaacggccgcgtggagatcatcgccaacgatcagggcaaccgc
atcacgccgtcttatgtggccttcactcctgaaggggagcgtttgatcggcgatgccgcc
aagaaccagctcacctccaaccctgagaacacggtcttcgacgccaagcggctcatcggc
cgcacatggaacgacccgtctgtgcagcaggacatcaagttcctgcctttcaaggttgtt
gagaagaaaactaaaccatacattcaagttgatattggaggtgggcaaacaaagacattt
gcccctgaagaaatttctgccatggttctcactaaaatgaaggaaactgcagaggcttat
ttaggaaagaaggttacccatgcagttgttactgtaccagcctatttcaatgatgcccaa
cgccaggcaaccaaagatgcaggaactattgctggattgaatgttatgaggatcattaat
gagcctacagcagccgctattgcttatggcttggataagcgggaaggggagaagaatatc
ctggtgtttgacttgggtggtggaacctttgatgtgtctcttctcaccattgacaatggt
gtcttcgaagtcgtggctactaatggagatactcatctggggggagaagactttgaccaa
cgtgtcatggaacacttcatcaaactctacaaaaagaagactggcaaagatgttaggaaa
gacaacagagctgtgcagaaactccggcgggaggtagaaaaggccaaacgggccctgtct
tctcaacatcaggcaagaattgaaattgagtctttctatgaaggggaagacttctctgag
actctgactcgggccaaatttgaagaactaaatatggatctgttccgttctaccatgaag
cctgttcagaaggtgctggaggattctgacttaaagaagtctgatattgatgaaattgtt
cttgttggtggctctactcgaatcccaaagattcaacaactggttaaagagttcttcaat
ggcaaggagccatcccgtggcatcaacccagatgaggctgtagcatacggtgctgctgtc
caggctggtgtactctctggtgatcaggatacaggtgatctggtactgcttgatgtatgt
ccccttacacttggtattgaaactgtgggaggtgtcatgaccaaactgattccaaggaac
accgtggtgcccacaaagaagtctcagatcttttctacagcttctgataaccaaccaact
gttacaatcaaggtctatgaaggtgaacgacccctgacaaaagacaatcaccttctggga
acttttgatctgactggaattcctcctgctccccgtggggtcccacagattgaagtcacc
tttgagatagatgtgaatggcattcttcgagtgacagctgaagacaaaggtacaggcaac
aaaaataagattacaattacgaatgaccaaaatcgcctgacacctgaagagattgaaagg
atggttaatgatgctgagaagtttgccgaggaagacaaaaagctcaaggagcgcattgat
actagaaatgaattggaaagctatgcctattctctaaagaatcagattggagataaagaa
aagctgggaggtaaactctcctctgaggataaggagaccatggaaaaagctgtagaggaa
aagattgaatggctagaaagtcatcaagatgctgacattgaagatttcaaagctaaaaag
aaggaactagaagaaattgttcagccaattatcagcaaactctatggaagtgcaggccct
cccccaactggtgatgaggaaccagcagacaaagatgagttgtag

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (9)   
   KEGG PATHWAY (9)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (8)   
   Pfam (8)   
All databases (35)   

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