KEGG   Ursus maritimus (polar bear): 103670382
Entry
103670382         CDS       T03271                                 
Symbol
TLR4
Name
(RefSeq) toll-like receptor 4
  KO
K10160  toll-like receptor 4
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr04064  NF-kappa B signaling pathway
umr04066  HIF-1 signaling pathway
umr04145  Phagosome
umr04151  PI3K-Akt signaling pathway
umr04217  Necroptosis
umr04613  Neutrophil extracellular trap formation
umr04620  Toll-like receptor signaling pathway
umr04621  NOD-like receptor signaling pathway
umr04936  Alcoholic liver disease
umr05132  Salmonella infection
umr05133  Pertussis
umr05134  Legionellosis
umr05135  Yersinia infection
umr05140  Leishmaniasis
umr05142  Chagas disease
umr05144  Malaria
umr05145  Toxoplasmosis
umr05146  Amoebiasis
umr05152  Tuberculosis
umr05161  Hepatitis B
umr05162  Measles
umr05164  Influenza A
umr05170  Human immunodeficiency virus 1 infection
umr05171  Coronavirus disease - COVID-19
umr05205  Proteoglycans in cancer
umr05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
umr05321  Inflammatory bowel disease
umr05323  Rheumatoid arthritis
umr05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    103670382 (TLR4)
   04066 HIF-1 signaling pathway
    103670382 (TLR4)
   04151 PI3K-Akt signaling pathway
    103670382 (TLR4)
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    103670382 (TLR4)
  09143 Cell growth and death
   04217 Necroptosis
    103670382 (TLR4)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    103670382 (TLR4)
   04620 Toll-like receptor signaling pathway
    103670382 (TLR4)
   04621 NOD-like receptor signaling pathway
    103670382 (TLR4)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    103670382 (TLR4)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    103670382 (TLR4)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    103670382 (TLR4)
   05161 Hepatitis B
    103670382 (TLR4)
   05171 Coronavirus disease - COVID-19
    103670382 (TLR4)
   05164 Influenza A
    103670382 (TLR4)
   05162 Measles
    103670382 (TLR4)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    103670382 (TLR4)
   05135 Yersinia infection
    103670382 (TLR4)
   05133 Pertussis
    103670382 (TLR4)
   05134 Legionellosis
    103670382 (TLR4)
   05152 Tuberculosis
    103670382 (TLR4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103670382 (TLR4)
   05144 Malaria
    103670382 (TLR4)
   05145 Toxoplasmosis
    103670382 (TLR4)
   05140 Leishmaniasis
    103670382 (TLR4)
   05142 Chagas disease
    103670382 (TLR4)
  09163 Immune disease
   05323 Rheumatoid arthritis
    103670382 (TLR4)
   05321 Inflammatory bowel disease
    103670382 (TLR4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103670382 (TLR4)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    103670382 (TLR4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:umr04131]
    103670382 (TLR4)
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors [BR:umr04054]
    103670382 (TLR4)
   04090 CD molecules [BR:umr04090]
    103670382 (TLR4)
   00536 Glycosaminoglycan binding proteins [BR:umr00536]
    103670382 (TLR4)
Membrane trafficking [BR:umr04131]
 Endocytosis
  Phagocytosis
   Toll-like receptors
    103670382 (TLR4)
Pattern recognition receptors [BR:umr04054]
 Membrane-bound pattern recognition receptors
  Toll-like receptors
   103670382 (TLR4)
CD molecules [BR:umr04090]
 Proteins
  103670382 (TLR4)
Glycosaminoglycan binding proteins [BR:umr00536]
 Hyaluronan
  Cell surface receptors
   103670382 (TLR4)
SSDB
Motif
Pfam: LRR_8 LRR_4 TIR LRR_1 TIR_2 LRR_5 LRR_9 LRR_6 ThsB_TIR
Other DBs
NCBI-GeneID: 103670382
NCBI-ProteinID: XP_008697062
UniProt: A0A452TBR0 A0A384CQG2
Position
Unknown
AA seq 833 aa
MMSPTRLAGMLIPAMAFLSFLRPESWEPCVQVVPNITYKCMELNLDKIPNNIPTSTKELD
LSFNPLRHLDSHSFSNFPELQVLDLSRCEIRIIEDDAYQGLNHLSILILTGNPIQELFPG
AFSGLSNLQMLVVVETNVQSLEDFPIGHLKTLKELNVAHNLIHSFKLPEYFSNMPNLEYL
DLSNNKIQNIYHKDLQVLRQMPLLNLSLDLSLNPLYFIQPGAFKEIKLHELTLRSNFNST
HVMKTCIQGLAGLKIHQLVLGEFKNERKLESFDKSLLEGLCDLTIEKFRIAYFDEFSKDT
TDLFNCLGNVSTISLVHLFLNRPRYLPKNLRWQRLEMVNCGFEEFPTWGLDSLKEFVFTA
NKGVNTFTEMNPNSLEFLDLSRNGLSFKGCCSHSELGTTRLKHLDLSFNDIITMSSNFLG
LEQLEYLDFQHSNLKQASDFSVFLSLRNLRYLDISYTHTQVVFHGIFDGLVSLQVLKMAG
NSFQDNFLPNIFKDLTNLTILDLSKCQLERVSQVAFGSLPKLQLINMSHNNLLSLDTLPY
EPLLSLQILDYSFNRIVASKERERQHFPSNLVSLNLTQNDFACVCEHQNFLQWVKDHRQL
LVEVEEMVCAKPLDMQGMPMLSFRNATCQRSKTIITVSVFTVLMVSLVAVLVYKFYFHLM
LLAGCKKYSKGESTYDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIA
ANIIQEGFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKSLL
RQQVELYRLLSRNTYLEWEDSVLGRHIFWRRLRKALLDGKQWSPEGTADAENS
NT seq 2502 nt   +upstreamnt  +downstreamnt
atgatgtctcctacccgcctggctgggatgctgatcccagccatggccttcctctccttc
ctgagacccgagagctgggagccttgtgtgcaggtggttcctaacattacttacaaatgc
atggaactgaatctcgacaaaattcccaacaacatccccacgtcaaccaaggaactggac
ctgagctttaaccccctgaggcatttagacagccatagcttctccaacttcccagaactt
caggtgttggatttatccaggtgtgaaattcggataattgaagatgatgcgtatcagggc
ctaaaccacctctccatcttgatattgacaggaaaccctatccaggagttattcccagga
gccttttctggactctcaaatttacagatgctggtggtcgtggagacaaatgtacaatct
ctagaggacttccccattggacatctcaaaaccttgaaggagcttaatgtagctcacaat
cttatccattccttcaagttacctgaatatttttctaacatgcccaacctggagtacttg
gatctttccaataacaagatccaaaatatttatcataaagacttgcaggttctacgtcaa
atgcctctactcaacctttctttagacttgtccctgaaccctttatactttatccaacca
ggtgcctttaaagaaattaaactccatgaactgactttgagaagtaattttaatagtaca
catgtaatgaaaacttgtattcaaggtctggctggtttaaagatccatcagttggttctg
ggagaatttaaaaatgaaaggaagttggaaagctttgataaatctctcctggagggactg
tgtgatttgaccattgaaaaattccggatagcatactttgatgagttctcaaaggatact
actgacttatttaattgtttgggaaatgtttctacaatttctctggtgcatctgttttta
aacaggccaagataccttcctaaaaatctcagatggcaacggttggaaatggttaactgt
ggatttgaagaatttcccacgtgggggctggactctctcaaggagtttgttttcactgcc
aacaaaggcgtgaacacttttactgagatgaacccgaacagccttgagtttctagatctc
agtagaaatggcctgagttttaagggttgctgttctcactctgaattggggacaaccaga
ctgaagcatttagatctgagcttcaatgatattattaccatgagttcaaacttcttgggc
ttagaacaactagaatatctagatttccagcattccaatttgaaacaggctagtgatttt
tcagtattcctatccctcagaaacctccgttaccttgatatttcttatactcacacccaa
gttgtcttccacggcatttttgatggcttggtcagcctccaagtcttgaaaatggctggt
aattcttttcaggacaacttccttccaaatattttcaaagacctgactaacttgaccatt
ctagatctctctaagtgtcagctggaacgggtgtcccaggtagcatttggttcacttccg
aaacttcagttgataaatatgagtcacaacaatctcctgtcattggatacactcccttat
gaacctctcctctccctccaaattctggattacagttttaatcgaatagtggcctccaaa
gagcgagaacgacagcattttccaagtaatctagtttccttaaatcttactcagaatgac
tttgcttgtgtttgtgaacaccagaacttcctgcagtgggtcaaggaccacaggcagctc
ttggtggaagttgaagaaatggtgtgtgcaaaacctttagacatgcagggcatgcccatg
ctgagttttaggaatgccacctgtcagaggagtaagactatcattactgtgtcggtgttc
actgtactcatggtttctctggtagcagttttggtgtataagttctatttccacctgatg
cttcttgctggctgcaaaaagtacagcaaaggcgaaagcacttatgatgccttcgttatc
tactcaagtcaagatgaagactgggtaaggaatgaactggtaaagaacttggaagagggg
gtgcccccctttcagctctgccttcactatagagacttcattcctggtgtggccattgct
gccaacatcatccaggaaggtttccacaaaagccggaaggttattgttgtggtgtcccaa
cacttcatccagagtcggtggtgtatctttgagtatgagattgcccagacctggcagttt
cttagtagtcgtgccggcatcatcttcattgttctgcagaaggtggagaagtccctgctg
cggcagcaggtggagctgtatcggcttcttagcaggaacacttacctagagtgggaagac
agtgtcctggggcggcacatcttctggagacgactccgaaaagccttgctggatggtaaa
cagtggagtccagaaggaacagcagatgcagaaaacagctag

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (29)   
   KEGG PATHWAY (29)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (9)   
   Pfam (9)   
All databases (56)   

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