KEGG   Ursus maritimus (polar bear): 103670673
Entry
103670673         CDS       T03271                                 
Symbol
PRKAA2
Name
(RefSeq) 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1
  KO
K07198  5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.31]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr04068  FoxO signaling pathway
umr04140  Autophagy - animal
umr04150  mTOR signaling pathway
umr04151  PI3K-Akt signaling pathway
umr04152  AMPK signaling pathway
umr04211  Longevity regulating pathway
umr04213  Longevity regulating pathway - multiple species
umr04371  Apelin signaling pathway
umr04530  Tight junction
umr04710  Circadian rhythm
umr04714  Thermogenesis
umr04910  Insulin signaling pathway
umr04920  Adipocytokine signaling pathway
umr04921  Oxytocin signaling pathway
umr04922  Glucagon signaling pathway
umr04931  Insulin resistance
umr04932  Non-alcoholic fatty liver disease
umr04936  Alcoholic liver disease
umr05410  Hypertrophic cardiomyopathy
umr05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    103670673 (PRKAA2)
   04068 FoxO signaling pathway
    103670673 (PRKAA2)
   04151 PI3K-Akt signaling pathway
    103670673 (PRKAA2)
   04152 AMPK signaling pathway
    103670673 (PRKAA2)
   04150 mTOR signaling pathway
    103670673 (PRKAA2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    103670673 (PRKAA2)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    103670673 (PRKAA2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    103670673 (PRKAA2)
   04922 Glucagon signaling pathway
    103670673 (PRKAA2)
   04920 Adipocytokine signaling pathway
    103670673 (PRKAA2)
   04921 Oxytocin signaling pathway
    103670673 (PRKAA2)
  09149 Aging
   04211 Longevity regulating pathway
    103670673 (PRKAA2)
   04213 Longevity regulating pathway - multiple species
    103670673 (PRKAA2)
  09159 Environmental adaptation
   04710 Circadian rhythm
    103670673 (PRKAA2)
   04714 Thermogenesis
    103670673 (PRKAA2)
 09160 Human Diseases
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    103670673 (PRKAA2)
   05410 Hypertrophic cardiomyopathy
    103670673 (PRKAA2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    103670673 (PRKAA2)
   04932 Non-alcoholic fatty liver disease
    103670673 (PRKAA2)
   04931 Insulin resistance
    103670673 (PRKAA2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:umr01001]
    103670673 (PRKAA2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:umr04131]
    103670673 (PRKAA2)
   03029 Mitochondrial biogenesis [BR:umr03029]
    103670673 (PRKAA2)
Enzymes [BR:umr01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.31  [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase
     103670673 (PRKAA2)
Protein kinases [BR:umr01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   103670673 (PRKAA2)
Membrane trafficking [BR:umr04131]
 Autophagy
  Other autophagy associated proteins
   Others
    103670673 (PRKAA2)
Mitochondrial biogenesis [BR:umr03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    103670673 (PRKAA2)
  Mitophagy factors
   Other mitophagy factors
    103670673 (PRKAA2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr AMPK_alpha_AID AdenylateSensor Kinase-like ABC1 Kdo APH
Other DBs
NCBI-GeneID: 103670673
NCBI-ProteinID: XP_040483191
UniProt: A0A8M1FII8
Position
Unknown
AA seq 552 aa
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPTGSFMDDSTMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSVTAESHSLSGSLTGSLTGSTLSSVPPRLGSHTMDFF
EMCASLITTLAR
NT seq 1659 nt   +upstreamnt  +downstreamnt
atggctgagaagcagaagcacgacgggcgggtgaagatcggacactacgtgctgggcgac
acgctgggcgtcggcaccttcggcaaagtgaagattggagaacatcaattgacaggccat
aaagtggcagttaaaatcttaaatagacagaagattcgcagtttagatgttgttggaaaa
ataaaacgagaaattcaaaacctaaaactctttcgtcatcctcatattatcaaactatac
caggtgatcagcactccaacagatttttttatggtgatggaatatgtgtctggtggtgaa
ttatttgactacatctgtaaacatggacgggttgaagaggtggaagcaaggcggctcttt
cagcagattctatcagctgtggattactgtcataggcatatggtggttcatcgagacctg
aaaccagagaatgtgctgttggatgctcacatgaatgccaagatagctgattttggattg
tctaatatgatgtcagatggtgaatttctgcgaactagttgtggatctccaaattatgca
gcacctgaagtcatctcaggcagattgtatgcaggtcctgaagttgatatctggagctgt
ggtgttattctgtatgcccttctttgtggcaccctcccatttgacgatgagcatgtacct
acgttatttaagaagatccgagggggtgttttttatatcccagaatatctcaatcgttct
gttgccactctcttgatgcatatgctgcaggttgaccccctgaaacgagcaaccatcaaa
gatataagagagcatgaatggtttaaacaagatttgcccagttacttatttcctgaagac
ccctcctatgatgctaacgtcattgatgatgaggctgtgaaagaagtgtgtgaaaaattt
gagtgtacagaatcagaagtaatgaacagtttatatagtggtgaccctcaagaccagctt
gcagtggcttatcatcttatcattgacaatcggagaataatgaaccaagccagtgagttc
tacctcgcctctagtcccccaactggttcttttatggatgatagtaccatgcatattccc
ccaggcctgaaacctcatccagaacggatgccacctcttatagcagacagccctaaagca
agatgtccattggatgcactgaacacaactaagcccaaatctttagctgtgaaaaaagcc
aagtggcatcttggaatcagaagtcaaagcaaaccgtatgacattatggctgaagtctac
cgagctatgaagcagctggattttgaatggaaggtagtgaatgcataccatcttcgtgta
agaaggaaaaatccagtgactggcaattatgtgaaaatgagcttacaactttacctggtt
gacaacagaagctatcttttggactttaaaagcattgatgatgaggtggtggagcagagg
tctggttcttcaacacctcagcgttcctgttctgccgctggcttacatagaccaagatca
agttttgattctgtaactgcagagagccattcactttccggctctctcactggctctttg
acgggaagcacattgtcttcagttccaccccgcctaggcagtcacaccatggattttttt
gaaatgtgtgccagtctgatcactactttagcccgttga

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (8)   
   Pfam (8)   
All databases (46)   

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