KEGG   Ursus maritimus (polar bear): 103673432Help
Entry
103673432         CDS       T03271                                 

Gene name
PLA2G4E
Definition
(RefSeq) phospholipase A2 group IVE
  KO
K16342  cytosolic phospholipase A2 [EC:3.1.1.4]
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr00564  Glycerophospholipid metabolism
umr00565  Ether lipid metabolism
umr00590  Arachidonic acid metabolism
umr00591  Linoleic acid metabolism
umr00592  alpha-Linolenic acid metabolism
umr01100  Metabolic pathways
umr04010  MAPK signaling pathway
umr04014  Ras signaling pathway
umr04072  Phospholipase D signaling pathway
umr04217  Necroptosis
umr04270  Vascular smooth muscle contraction
umr04370  VEGF signaling pathway
umr04611  Platelet activation
umr04664  Fc epsilon RI signaling pathway
umr04666  Fc gamma R-mediated phagocytosis
umr04724  Glutamatergic synapse
umr04726  Serotonergic synapse
umr04730  Long-term depression
umr04750  Inflammatory mediator regulation of TRP channels
umr04912  GnRH signaling pathway
umr04913  Ovarian steroidogenesis
umr04921  Oxytocin signaling pathway
umr05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:umr00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    103673432 (PLA2G4E)
   00565 Ether lipid metabolism
    103673432 (PLA2G4E)
   00590 Arachidonic acid metabolism
    103673432 (PLA2G4E)
   00591 Linoleic acid metabolism
    103673432 (PLA2G4E)
   00592 alpha-Linolenic acid metabolism
    103673432 (PLA2G4E)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    103673432 (PLA2G4E)
   04010 MAPK signaling pathway
    103673432 (PLA2G4E)
   04370 VEGF signaling pathway
    103673432 (PLA2G4E)
   04072 Phospholipase D signaling pathway
    103673432 (PLA2G4E)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    103673432 (PLA2G4E)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103673432 (PLA2G4E)
   04664 Fc epsilon RI signaling pathway
    103673432 (PLA2G4E)
   04666 Fc gamma R-mediated phagocytosis
    103673432 (PLA2G4E)
  09152 Endocrine system
   04912 GnRH signaling pathway
    103673432 (PLA2G4E)
   04913 Ovarian steroidogenesis
    103673432 (PLA2G4E)
   04921 Oxytocin signaling pathway
    103673432 (PLA2G4E)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103673432 (PLA2G4E)
  09156 Nervous system
   04724 Glutamatergic synapse
    103673432 (PLA2G4E)
   04726 Serotonergic synapse
    103673432 (PLA2G4E)
   04730 Long-term depression
    103673432 (PLA2G4E)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    103673432 (PLA2G4E)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    103673432 (PLA2G4E)
Enzymes [BR:umr01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.4  phospholipase A2
     103673432 (PLA2G4E)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: cPLA2_C2 PLA2_B C2 CEP76-C2
Motif
Other DBs
NCBI-GeneID: 103673432
NCBI-ProteinID: XP_008700442
UniProt: A0A384D035
Position
Un
AA seq 863 aa AA seqDB search
MTLQSSEGCPGLGTDVFIPQSLQEAEEDSRSERNVSEFELPRDPEPPNLPPLLPMAPWGS
EGGLSPCHLLTVKVIRMKNVRQADRVSQTDCFVSLWLPTASHERLRTRTISNCPNPEWNE
TFSFQIQSQVKNVLELSVCDEDTLTPDDHLLTILYDLTKLCFRKKTHVKFPLNPEGMEEL
EVEFLLEESPSPPEILITNGVLVSRQVSCLEVHAECRRRRKSRKMKDLLVTVKESFEHTQ
RVSCCQEPCPPNPACFHYPKYFQPCMHVDVPKSQCSRGLCCCCAPRKNSPVRQPLDCLPD
GQTVALPVGENCELHMKSTPCPQTLDVRLGFSLCPAEQEFLQKRKPVVAQALQEVLQLEA
DLPVDEVPLIAIMATGGGTRSMTAMYGHLLGLQKLNLLNCASYITGLSGATWTMATLYRD
PDWSSKNLEPAIFEARRHVVKDKMPALFPDQLSKFQEELRQRSQEGYKVTFTDFWGLLIE
ACLGDERNESKLSDQRAALCQGQNPLPVYLTINVKDDVSNQDFREWCEFSPYEVGLQKYG
AFIPTELFGSEFFMGRLMKRIPESRMCYMLGLWSSIFSLNLLDAWNLSQSSEEFFHRWTR
ERVHDIEDEPLLPEIPKCDANVLDTAVVIPGSWLSNTFRSILTHRAFVSQFHNFLLGLQL
HTDYLQNSQFSMWRDTVLDGFPNQLTESVNHLCLLDTAFFVNSSYPPLLRPERKVDLIIH
LNYCAGSQTKPMKQTCEYCTVQNIPFPKYELQEDEDSLKECYLMENPQEPDAPIVLFFPL
INDTFQKYKAPGVERSPEELEQGHVDIYGPKTPYATKELTYTEAAFDKLVKLSEYNILNN
KDKLLQALRLAVEKKRLKSQCPS
NT seq 2592 nt NT seq  +upstreamnt  +downstreamnt
atgactctccagagctcggaaggctgtcctggcctgggaactgacgtgttcatcccccag
agcctgcaagaggctgaagaagacagcaggtcagaaagaaatgtcagtgagttcgagctg
ccacgggacccagaacctcctaatctcccacctctgcttcccatggccccttggggctct
gagggcgggctgtctccatgccacctgctgaccgtgaaggtcatccggatgaaaaacgtc
cgacaggctgatagggtgagccagacagattgctttgtgagcctctggctgcccaccgct
tctcatgagaggttgaggactaggaccatctccaactgtccgaacccagagtggaatgaa
accttcagcttccagatccagagccaagtgaagaacgtgctagagctgagcgtctgtgat
gaagacacactgaccccagatgaccatctcttgacaatcctctatgacctcaccaaactc
tgcttccggaagaaaacccacgtgaagttcccactcaacccagagggcatggaagagctg
gaggtggagttcctgctggaggagagtccctctccacccgagatcctcatcaccaatggc
gtgctggtgtctcggcaagtttcctgcctggaggttcatgcagaatgcaggaggcggagg
aagagcaggaaaatgaaggacctcctggtgacagtgaaggagtccttcgagcacacccaa
cgcgtctcgtgctgccaggagccctgccccccaaacccagcctgcttccactaccccaag
tacttccagccctgcatgcacgtggacgtgcccaagagccagtgcagccgtgggctttgc
tgctgctgtgcacccaggaagaacagccctgtccgccagccccttgactgcctccccgat
ggccagaccgtcgccctgccggtgggcgagaactgtgaattacacatgaagtctacaccc
tgccctcagacgctggacgtgcggctgggcttcagcctgtgcccggcagagcaggagttc
ctgcagaagcggaagccggtggtggcgcaggcgctgcaggaggtgttgcagctggaggcc
gacctgcctgtggacgaggtgccgctgatagccatcatggcgacagggggcggaacgaga
tccatgaccgccatgtacggccacctgctggggctgcagaagctgaacctcctgaactgt
gccagctacatcactggcctgtccggggccacctggaccatggcgaccttataccgtgac
cccgactggtcctccaaaaacctggagcccgccatatttgaggcacggaggcatgtggtc
aaggacaagatgcctgccctgttcccagaccagctgtccaaattccaggaggagcttcgg
cagcgcagccaggaaggctacaaggtcacctttacagatttctggggcctgctgattgag
gcctgtctgggggatgagagaaatgaatccaaactgtcagatcagcgtgctgctttgtgc
cagggccagaaccccctgcccgtctacctcaccatcaatgtcaaggatgatgtaagcaac
caggatttcagagagtggtgcgagttctccccctacgaggtgggcctgcagaagtacggg
gccttcatccccaccgagctcttcggctccgagttcttcatggggcggctgatgaagagg
atcccagagtcgcgaatgtgctacatgctaggcttgtggagcagtatcttctcactaaac
ttgcttgatgcctggaatctgtcccaaagctcggaggagtttttccacaggtggacgagg
gagagagtgcatgatatcgaagatgagcccctcctgcctgaaatccccaaatgtgatgcc
aacgtcttggacactgcggtggtgatcccggggtcgtggctgtccaatactttccgcagc
atcctcacgcaccgggccttcgtgtcccagttccacaacttcctgttggggctgcagctg
cacaccgactacctccagaacagccagttctccatgtggagagacacggtgctagatggt
ttcccgaaccagctgacagagtccgtgaaccacttgtgcctgttggacactgcgttcttc
gtcaactccagctacccgcccctccttaggcccgagagaaaagtcgacctcatcattcac
ctcaattactgcgctgggtcccagacaaagccaatgaaacaaacatgtgagtactgcacc
gtgcagaacatccccttccccaaatacgagctgcaagaggacgaggacagcctcaaggag
tgctacttgatggagaacccccaggagcctgatgcccccatcgtgcttttcttcccactc
atcaacgacaccttccagaagtacaaggccccaggtgtggagcgaagccccgaggagctg
gaacagggccacgtggacatttatggccccaaaactccatacgctaccaaggagctgaca
tacacagaggctgcctttgacaagctggtgaagctctctgagtacaacatcctgaataac
aaggacaagctccttcaggccttgagactggcggtggagaagaaacgtctgaagagccag
tgtccctcctaa

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