KEGG   Ursus maritimus (polar bear): 103675324
Entry
103675324         CDS       T03271                                 
Symbol
CACNA1B
Name
(RefSeq) voltage-dependent N-type calcium channel subunit alpha-1B isoform X1
  KO
K04849  voltage-dependent calcium channel N type alpha-1B
Organism
umr  Ursus maritimus (polar bear)
Pathway
umr04010  MAPK signaling pathway
umr04020  Calcium signaling pathway
umr04721  Synaptic vesicle cycle
umr04723  Retrograde endocannabinoid signaling
umr04725  Cholinergic synapse
umr04726  Serotonergic synapse
umr04727  GABAergic synapse
umr04728  Dopaminergic synapse
umr04930  Type II diabetes mellitus
umr05016  Huntington disease
umr05020  Prion disease
umr05022  Pathways of neurodegeneration - multiple diseases
umr05032  Morphine addiction
umr05033  Nicotine addiction
umr05207  Chemical carcinogenesis - receptor activation
Brite
KEGG Orthology (KO) [BR:umr00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103675324 (CACNA1B)
   04020 Calcium signaling pathway
    103675324 (CACNA1B)
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    103675324 (CACNA1B)
   04725 Cholinergic synapse
    103675324 (CACNA1B)
   04728 Dopaminergic synapse
    103675324 (CACNA1B)
   04726 Serotonergic synapse
    103675324 (CACNA1B)
   04723 Retrograde endocannabinoid signaling
    103675324 (CACNA1B)
   04721 Synaptic vesicle cycle
    103675324 (CACNA1B)
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    103675324 (CACNA1B)
  09164 Neurodegenerative disease
   05016 Huntington disease
    103675324 (CACNA1B)
   05020 Prion disease
    103675324 (CACNA1B)
   05022 Pathways of neurodegeneration - multiple diseases
    103675324 (CACNA1B)
  09165 Substance dependence
   05032 Morphine addiction
    103675324 (CACNA1B)
   05033 Nicotine addiction
    103675324 (CACNA1B)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    103675324 (CACNA1B)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:umr04040]
    103675324 (CACNA1B)
Ion channels [BR:umr04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   103675324 (CACNA1B)
SSDB
Motif
Pfam: Ion_trans Ca_chan_IQ GPHH PKD_channel Phage_TAC_15
Other DBs
NCBI-GeneID: 103675324
NCBI-ProteinID: XP_040488245
UniProt: A0A8M1G0G9
Position
Unknown
AA seq 2344 aa
MVRFGDELGSRYGGTGGERARGGGAGGAGGPGPGGLQPGQRVLYKQSIAQRARTMALYNP
IPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDG
DKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILAT
AGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIG
LEFYMGKFHKACFPNSTDPDPVGDFPCGKEAPARLCEGDTECREYWPGPNFGITNFDNIL
FAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAK
ERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVMLAEEDKNAEEKSPLDVLKRAAT
KKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRVVKA
QSFYWVVLCVVALNTLCVAMVHYDQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSY
FRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRIFKVTKYWSSLRNLVVS
LLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQDETPTTNFDTFPAAILTVFQILT
GEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD
EEEMEEAANQKLALQKAKEVADVSPMSAANISIAAAPQNSAKARSVWEQRASQLRLRNLR
ASCEALYSEMDPEERLRYATTRHLRPDMKTHLDRPLVVELGRDGPRVPAGGKARPEGTEA
AEGADPPRRHHRHRDKVPAPVPAPAAAGEQDRGDAPKAEGGEPGAREERPRPHRSRSKEA
RSDKEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHAPDQGKEGSAAGAKGE
RRARHRGGPRAGPREAGSGEEPARRHRARHKALPTHEDAEKEDAEKEAAEKEGEVEDRDR
EKELRNHQPKEPHCELEASGIVGVGPVHALPSTCLQKVEGQPEDADNQRNVTRMGSQPSD
LSATVHIPVTLTGPPGETTAVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCL
SPTNLLRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDSPRNNALKYMDYIFTGV
FTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVL
RVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILVVYMLFMFIFAVIAVQLFKGKFFYCTD
ESKGLERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLKH
SVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLE
KNERACIDFAISAKPLTRYMPQDKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFY
DAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVT
EIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY
AIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDEH
ANASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVW
AEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTS
TLMALIRTALEIKLAPAGTKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGK
VYAALMIFDFYKQNKTTRDQIHQATGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLR
QKSSASLSNGGAVQTQESGIKESVSWGTQRTQEVPYEARTPLERGHSTEIPVVQSGKPAV
DVQMQSMALRGPDGEPQPGLESQGRAASMPRLAAETQPAPNASPMKRSISTLAPQRPHVA
HLCSAALDRAPASQAVAHHHHRCHRRRDRKQKSLEKGPSLSADTDGAPSSAAGPGPPPGE
GPTGCRRERRQERGRSQERRQPSSSSSEKQRFYSCDRFGGREPSQPKPSLSSHPTSPTAG
QEPGPPRPGGGSVSGSPLLSTSGASTPGRGGRRQLPQTPLTPRPSVTYKTANSSPVHFAG
AQTSLPTFSPGRLSRGLSEHNALLQRDPLSQPLAAGSRIGSDPYLGQRLDSEDTARTQPE
DTLTFEEAVATNSGRSSRTSYVSSLTSQPHPLRRVPNGYHCTLGLSSGGRVRHSYHHPDQ
DHWC
NT seq 7035 nt   +upstreamnt  +downstreamnt
atggtccgcttcggggacgagctgggcagccgctatgggggcaccggtggggagcgggct
cggggcggcggggccggcggggcgggcggcccggggcccggggggctgcagccgggccag
cgggtcctctacaagcagtcgatcgcgcagcgcgcgcggaccatggcgctgtacaacccc
atcccagtcaagcagaactgcttcaccgtcaaccgctcgctcttcgtcttcagcgaggac
aacgtcgtccgcaaatacgccaagcgcatcaccgagtggcctccgttcgagtacatgatc
ctggccaccatcatcgccaactgtatcgtgctggcgctggagcagcacctccccgacggc
gacaagactcccatgtccgagcggctggatgacacagagccctatttcattggcatcttc
tgctttgaggcggggatcaagatcatagctctgggctttgtcttccacaagggctcctac
ctgcggaacggctggaacgtcatggacttcgtggtggttctcacagggatcctggccaca
gccggcactgactttgacctgcggaccctgcgggctgtgcgcgtccttaggcccctgaag
ctggtatctgggattccgagtttgcaggtggtgctcaagtccatcatgaaggccatggtt
ccactcctgcagatcgggttgcttctcttcttcgccatcctcatgttcgccatcattggc
ctcgagttctacatgggcaaattccacaaggcctgtttccccaacagcacagatccagat
ccagtgggtgacttcccctgtggcaaagaggcccccgcccggctgtgtgagggcgacact
gaatgtcgggagtactggccagggcccaactttggcatcaccaactttgacaacatcctg
tttgccatcttgacggtgttccagtgtatcaccatggagggctggactgacatcctgtac
aacaccaatgatgcagctggcaacacctggaactggctctacttcatccctctcatcatc
attggctccttcttcatgctcaacctggtgctgggtgtgctctcaggcgagtttgccaag
gagcgtgagagggtcgagaaccgccgggccttcctgaagctccgccggcagcagcagatt
gagcgggagctcaatgggtacctggagtggatcttcaaggccgaggaagtcatgctggcc
gaggaggacaagaatgcggaggagaagtcccctctggatgtgttgaagagagcggccacc
aagaagagccggaatgacctgatccacgcggaggagggggaggaccggtttgcagacctc
tgtgctgttgggtcccccttcgcccgtgccagcctcaagagcgggaagaccgagagctcg
tcgtacttccgtaggaaggagaagatgttccggttcttcatccggcgcgtggtgaaggca
cagagcttctactgggtggtgctgtgcgtggtggccctgaacacactgtgcgtggccatg
gtgcactatgaccagccgcagcggctcaccacggcgctgtactttgcagagtttgttttc
ctgggtctcttcctcacagagatgtccctgaagatgtatggcctggggcccagaagctac
ttccggtcctcattcaactgcttcgactttggggtcatcgtggggagcatctttgaagtg
gtctgggcggccatcaagccaggaacctccttcgggatcagtgtgctgcgggccctgcgc
ttgctgagaatcttcaaagtcacgaagtactggagctccttgcggaacctggtggtgtct
ctgctcaactccatgaagtccatcatcagcctcctcttcctgctgttcctgttcattgtg
gtcttcgctctgctgggcatgcagctgttcgggggacagttcaactttcaggatgagacc
ccgacaacgaactttgacactttccctgcggccattctcactgtcttccagatcctaaca
ggagaggactggaacgcagtgatgtaccacgggatcgaatcgcaaggtggagtcagcaaa
ggcatgttctcctccttttacttcattgtcctgacgctgtttggaaattacactctgctg
aatgtcttcctggccatcgccgtggacaacctcgccaatgctcaggagctgaccaaggac
gaagaggagatggaagaagcagccaaccagaagcttgctctgcaaaaagccaaagaagtg
gctgacgtcagtcccatgtccgcggcgaacatctccattgctgctgcgccgcagaactcg
gccaaggcgcgctcggtgtgggagcagcgggccagccagctgcggctgcggaacctgcgg
gccagctgcgaggcgctgtacagcgagatggaccccgaggagaggctgcgctacgccacc
acgcgccacctgcggccagacatgaagacgcacctggaccggccgctcgtggtggagcta
ggccgcgacgggccgcgggtccccgcgggaggcaaggcccggccagagggcacggaggcg
gccgagggcgcggacccgccgcgcaggcaccaccggcaccgcgacaaggtcccggccccg
gtccctgccccggcggcagcgggggagcaggacaggggggacgccccgaaggccgagggc
ggggagcccggggcccgggaagagcggccgcggccgcaccgcagccgcagcaaggaggcc
cggagtgacaaggaggcccggagtgagcgtggccgcggcccgggtcccgagggcggccgg
cgccaccaccggcgcggctccccggaggaggcggccgagcgggagccccggcgccaccgc
gcccaccggcacgcgcccgaccagggcaaggaaggcagcgcggctggggccaagggcgag
cggcgagcgcgccaccgcggcggcccccgggccggccccagggaggccgggagcggggag
gagccggcgcgtcggcaccgggcccggcacaaggcgctgcccacgcacgaggatgcagaa
aaggaggatgcagaaaaggaggcagcggagaaggagggcgaggtcgaggaccgggacagg
gagaaggagctccggaaccaccagcccaaggaaccacactgtgagctggaggccagtggg
atagtgggtgtgggccctgtgcatgcattgcccagcacgtgtctacagaaggtggagggg
cagccagaggatgcagataatcagcggaatgtcacgcggatgggcagtcaaccctcggac
ctgagtgctacagtgcatatcccagtgacgctgaccggccctcctggggagaccacggct
gttcccagtggtaacgtggacctggagagccaagccgaggggaagaaggaggtggaagct
gatgatgtgatgaggagtggcccccgacccatcgtcccatacagctccatgttctgttta
agccccaccaacctgctccgccgcttctgccattacatcgtgaccatgcggtacttcgag
atggtcattcttgtggtcatcgccctgagcagtattgccctggccgctgaggatccggtg
cggacagactcgcccaggaacaacgctctgaagtacatggactacattttcacaggggtc
ttcacctttgagatggtgataaagatgatcgatttgggactgctgctgcaccctggggcc
tacttccgggacctatggaatattctggacttcatcgtggtcagtggggccctggtggca
tttgccttctcaggatccaaagggaaagacatcaacaccatcaagtccctgagagtcttg
cgtgtcctgcggcccctcaagaccataaaacggctgcctaagctcaaggctgtgttcgac
tgtgtggtgaactcgctgaagaacgtcctcaacatcctggtcgtctacatgctcttcatg
ttcatcttcgccgtcatcgcggtgcagctcttcaaagggaagttcttctactgcacggac
gagtccaaggggctggagagggactgccggggccagtatttggattatgagaaggaggag
gtggaagcccagccacggcagtggaagaagtacgattttcactatgacaacgtgctctgg
gctctgctgacactgttcacagtgtccacaggagaggggtggcccatggtcctgaaacac
tctgtggacgccacctacgaggagcaaggccccagccccgggtaccgcatggagctgtcc
atcttctatgtggtctacttcgtggtcttccccttcttcttcgtcaacatcttcgtggcc
ttgatcatcatcaccttccaggagcagggggacaaggtgatgtctgaatgcagcctggag
aagaacgagagggcttgcatcgacttcgccatcagtgccaagcccctgacgcggtacatg
ccccaggacaagcagtcgttccagtacaagacatggacatttgtggtctcacctcccttc
gagtacttcatcatggccatgatcgccctcaacacagtggtgctgatgatgaagttctat
gacgcaccgtatgaatatgagctaatgttgaaatgcctgaacatcgtgttcacatccatg
ttctccatggaatgcgtgctgaagatcatcgcttttggggtactgaactatttcagagat
gcctggaatgtctttgactttgtcactgtgttgggaagtattactgatattttagtaaca
gagattgcggaaacgaacaacttcatcaacctcagcttcctccgcctcttccgtgccgcc
cgactcatcaagctgctccgccagggctacaccatccgcatcctgctgtggaccttcgtc
cagtccttcaaggccctgccctacgtgtgtctgctcatcgccatgctgttcttcatctac
gccatcatcggcatgcaggtttttggaaatatcgccctggatgatgacaccagcatcaac
cggcacaacaacttccggacgtttttacaggctttgatgctcttgttcaggagtgccact
ggggaggcctggcacgagatcatgctgtcttgtctcagcaaccaagcctgcgacgagcac
gccaatgccagtgagtgtgggagcgacttcgcctacttttacttcgtctccttcatcttc
ctttgctcctttctgatgttgaacctctttgtggccgtgatcatggacaattttgagtac
cttacacgggactcttccatcctagggcctcaccacctggacgagttcatccgggtctgg
gctgagtacgacccggccgcgtgtgggcgcatcagttacaatgacatgtttgagatgctg
aaacacatgtccccacccctggggctggggaagaaatgccctgctcgagttgcctacaag
cgcctggttcgcatgaacatgcccatctccaatgaggacatgactgtccacttcacgtcc
acgctgatggccctcattcggactgcactggagatcaagctggctccagctggcacgaag
cagcatcagtgtgatgcagagttgaggaaggagatttcctctgtgtgggccaatctgccc
cagaagacgctggacttactggtgccaccccataaacccgatgagatgacagtgggaaaa
gtatatgcagctctgatgatatttgacttctacaagcagaacaagaccaccagagaccag
attcaccaggccacaggaggcctgtcccagatgggccctgtgtccctgttccaccccctg
aaggccacactggagcagacacagccggctgtgctccgaggagcccgggttttccttcgg
cagaagagctcggcatccctcagcaatggtggggcagtacaaacccaagagagtggcatc
aaggagtctgtttcctggggcactcagaggacccaggaggtaccctatgaggcaaggaca
cccctggagcgtggccactctacggagatcccagtggtgcagtcaggaaaaccggctgtg
gatgtccagatgcagagcatggccctgagaggtcctgacggggagccccaacctggactg
gagagccaaggacgagcggcctccatgccccgcctggctgcagagactcagccggccccc
aacgccagccccatgaagcgctccatctccactctggcgccccagcgcccccacgtggct
catctctgcagcgctgccctggaccgcgccccagccagccaggctgtggcccaccaccac
caccgctgccatcgccgcagggaccggaagcagaagtccctggagaaggggcccagcctg
tccgcagacacagatggcgcacccagcagcgctgcggggccaggcccacccccgggagag
gggcccacaggctgccggagggagcgcagacaggagcggggccggtcccaagagcggagg
cagccctcttcctcgtcctcagagaagcagcgcttctactcctgtgaccgctttgggggc
cgtgagccctcgcagcccaaaccctccctcagcagccaccccacatcaccaacagctggg
caggagccaggacccccgagaccgggtggaggttcagtgagtgggagccccttgttgtca
acatccggtgctagcacccctggccgcggtgggcggagacagctcccccagaccccgctg
acaccccggcccagcgtcacctacaagacggccaactcttcgcctgtgcactttgctggg
gcacagaccagcctccccaccttttccccaggccggcttagccgtggcctttccgaacac
aacgctctgctccagagagaccccctcagccagcctctggccgccggctctaggatcggc
tccgacccttacttggggcagcgtctggacagtgaggacactgcccgcacccagcctgag
gacacgcttaccttcgaggaggctgtggccaccaactcgggccgctcctcccggacttcc
tacgtgtcctctctgacctcccagccccaccccctccgccgcgtgcccaacggctaccac
tgcactctgggactcagctcgggcggccgggtgcggcacagctaccaccaccccgaccag
gaccactggtgctag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (15)   
   KEGG PATHWAY (15)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (4)   
   RefSeq(nuc) (2)   
   GenBank (1)   
   EMBL (1)   
Protein domain (5)   
   Pfam (5)   
All databases (34)   

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