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Database: UniProt
Entry: Q9H3W5
LinkDB: Q9H3W5
Original site: Q9H3W5 
ID   LRRN3_HUMAN             Reviewed;         708 AA.
AC   Q9H3W5; O43377; Q6I9V8; Q8IYQ6;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   11-DEC-2019, entry version 154.
DE   RecName: Full=Leucine-rich repeat neuronal protein 3;
DE   AltName: Full=Neuronal leucine-rich repeat protein 3;
DE            Short=NLRR-3;
DE   Flags: Precursor;
GN   Name=LRRN3; ORFNames=Nbla10363, UNQ194/PRO220;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Jin L., Yu L., Zhao S.Y.;
RT   "Cloning of a new human cDNA homologous to Mus musculus leucine-rich repeat
RT   protein.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Hamano S., Inuzuka H., Morohashi A., Ohira M., Nakagawara A.;
RT   "Human neuronal leucine-rich repeat protein-3 (NLRR-3).";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Amygdala;
RX   PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA   Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA   Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA   Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA   Wiemann S., Schupp I.;
RT   "The full-ORF clone resource of the German cDNA consortium.";
RL   BMC Genomics 8:399-399(2007).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
DR   EMBL; AF134481; AAP97258.1; -; mRNA.
DR   EMBL; AB060967; BAB47184.1; -; mRNA.
DR   EMBL; AY358280; AAQ88647.1; -; mRNA.
DR   EMBL; CR457397; CAG33678.1; -; mRNA.
DR   EMBL; AL442092; CAC09450.1; -; mRNA.
DR   EMBL; BC035133; AAH35133.1; -; mRNA.
DR   CCDS; CCDS5754.1; -.
DR   RefSeq; NP_001093128.1; NM_001099658.1.
DR   RefSeq; NP_001093130.1; NM_001099660.1.
DR   RefSeq; NP_060804.3; NM_018334.4.
DR   SMR; Q9H3W5; -.
DR   BioGrid; 120095; 3.
DR   IntAct; Q9H3W5; 2.
DR   STRING; 9606.ENSP00000397312; -.
DR   PhosphoSitePlus; Q9H3W5; -.
DR   BioMuta; LRRN3; -.
DR   DMDM; 74761421; -.
DR   jPOST; Q9H3W5; -.
DR   MassIVE; Q9H3W5; -.
DR   MaxQB; Q9H3W5; -.
DR   PaxDb; Q9H3W5; -.
DR   PeptideAtlas; Q9H3W5; -.
DR   PRIDE; Q9H3W5; -.
DR   ProteomicsDB; 80766; -.
DR   DNASU; 54674; -.
DR   Ensembl; ENST00000308478; ENSP00000312001; ENSG00000173114.
DR   Ensembl; ENST00000422987; ENSP00000412417; ENSG00000173114.
DR   Ensembl; ENST00000451085; ENSP00000397312; ENSG00000173114.
DR   GeneID; 54674; -.
DR   KEGG; hsa:54674; -.
DR   UCSC; uc003vfs.5; human.
DR   CTD; 54674; -.
DR   DisGeNET; 54674; -.
DR   EuPathDB; HostDB:ENSG00000173114.12; -.
DR   GeneCards; LRRN3; -.
DR   HGNC; HGNC:17200; LRRN3.
DR   HPA; HPA043820; -.
DR   HPA; HPA046792; -.
DR   neXtProt; NX_Q9H3W5; -.
DR   OpenTargets; ENSG00000173114; -.
DR   PharmGKB; PA30468; -.
DR   eggNOG; KOG0619; Eukaryota.
DR   eggNOG; COG4886; LUCA.
DR   GeneTree; ENSGT00940000160513; -.
DR   HOGENOM; HOG000252914; -.
DR   OMA; PQLCTCE; -.
DR   OrthoDB; 998247at2759; -.
DR   PhylomeDB; Q9H3W5; -.
DR   TreeFam; TF334360; -.
DR   ChiTaRS; LRRN3; human.
DR   GeneWiki; LRRN3; -.
DR   GenomeRNAi; 54674; -.
DR   Pharos; Q9H3W5; Tbio.
DR   PRO; PR:Q9H3W5; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q9H3W5; protein.
DR   Bgee; ENSG00000173114; Expressed in 206 organ(s), highest expression level in neocortex.
DR   ExpressionAtlas; Q9H3W5; baseline and differential.
DR   Genevisible; Q9H3W5; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0051965; P:positive regulation of synapse assembly; IEA:Ensembl.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 2.
DR   Gene3D; 3.80.10.10; -; 3.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000372; LRRNT.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF13855; LRR_8; 3.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00369; LRR_TYP; 8.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00013; LRRNT; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51450; LRR; 10.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Leucine-rich repeat;
KW   Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..708
FT                   /note="Leucine-rich repeat neuronal protein 3"
FT                   /id="PRO_0000045823"
FT   TOPO_DOM        23..628
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        629..649
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        650..708
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          23..69
FT                   /note="LRRNT"
FT   REPEAT          70..91
FT                   /note="LRR 1"
FT   REPEAT          93..114
FT                   /note="LRR 2"
FT   REPEAT          117..138
FT                   /note="LRR 3"
FT   REPEAT          141..162
FT                   /note="LRR 4"
FT   REPEAT          165..186
FT                   /note="LRR 5"
FT   REPEAT          189..210
FT                   /note="LRR 6"
FT   REPEAT          213..234
FT                   /note="LRR 7"
FT   REPEAT          237..258
FT                   /note="LRR 8"
FT   REPEAT          261..282
FT                   /note="LRR 9"
FT   REPEAT          285..304
FT                   /note="LRR 10"
FT   REPEAT          310..332
FT                   /note="LRR 11"
FT   REPEAT          335..358
FT                   /note="LRR 12"
FT   DOMAIN          368..421
FT                   /note="LRRCT"
FT   DOMAIN          421..514
FT                   /note="Ig-like C2-type"
FT   DOMAIN          523..617
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        223
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        382
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        522
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        579
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        608
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        624
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        625
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        444..496
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT   VARIANT         24
FT                   /note="D -> G (in dbSNP:rs9942557)"
FT                   /id="VAR_049901"
FT   CONFLICT        96
FT                   /note="G -> S (in Ref. 6; AAH35133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        533
FT                   /note="Q -> H (in Ref. 6; AAH35133)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        541
FT                   /note="W -> R (in Ref. 4; CAG33678)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   708 AA;  79424 MW;  24710478D6B124D1 CRC64;
     MKDMPLRIHV LLGLAITTLV QAVDKKVDCP RLCTCEIRPW FTPRSIYMEA STVDCNDLGL
     LTFPARLPAN TQILLLQTNN IAKIEYSTDF PVNLTGLDLS QNNLSSVTNI NVKKMPQLLS
     VYLEENKLTE LPEKCLSELS NLQELYINHN LLSTISPGAF IGLHNLLRLH LNSNRLQMIN
     SKWFDALPNL EILMIGENPI IRIKDMNFKP LINLRSLVIA GINLTEIPDN ALVGLENLES
     ISFYDNRLIK VPHVALQKVV NLKFLDLNKN PINRIRRGDF SNMLHLKELG INNMPELISI
     DSLAVDNLPD LRKIEATNNP RLSYIHPNAF FRLPKLESLM LNSNALSALY HGTIESLPNL
     KEISIHSNPI RCDCVIRWMN MNKTNIRFME PDSLFCVDPP EFQGQNVRQV HFRDMMEICL
     PLIAPESFPS NLNVEAGSYV SFHCRATAEP QPEIYWITPS GQKLLPNTLT DKFYVHSEGT
     LDINGVTPKE GGLYTCIATN LVGADLKSVM IKVDGSFPQD NNGSLNIKIR DIQANSVLVS
     WKASSKILKS SVKWTAFVKT ENSHAAQSAR IPSDVKVYNL THLNPSTEYK ICIDIPTIYQ
     KNRKKCVNVT TKGLHPDQKE YEKNNTTTLM ACLGGLLGII GVICLISCLS PEMNCDGGHS
     YVRNYLQKPT FALGELYPPL INLWEAGKEK STSLKVKATV IGLPTNMS
//
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