GenomeNet

Database: UniProt
Entry: SOAT_HUMAN
LinkDB: SOAT_HUMAN
Original site: SOAT_HUMAN 
ID   SOAT_HUMAN              Reviewed;         377 AA.
AC   Q3KNW5; Q70EX7;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 2.
DT   17-JUN-2020, entry version 115.
DE   RecName: Full=Solute carrier family 10 member 6;
DE   AltName: Full=Sodium-dependent organic anion transporter;
GN   Name=SLC10A6; Synonyms=SOAT;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, GLYCOSYLATION,
RP   AND PROBABLE MEMBRANE TOPOLOGY.
RC   TISSUE=Adrenal gland, and Testis;
RX   PubMed=17491011; DOI=10.1074/jbc.m702663200;
RA   Geyer J., Doering B., Meerkamp K., Ugele B., Bakhiya N., Fernandes C.F.,
RA   Godoy J.R., Glatt H., Petzinger E.;
RT   "Cloning and functional characterization of human sodium-dependent organic
RT   anion transporter (SLC10A6).";
RL   J. Biol. Chem. 282:19728-19741(2007).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT VAL-114.
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Transports sulfoconjugated steroid hormones, as well as
CC       taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes in a
CC       sodium-dependent manner. {ECO:0000269|PubMed:17491011}.
CC   -!- INTERACTION:
CC       Q3KNW5; Q9ULC5: ACSL5; NbExp=3; IntAct=EBI-18159983, EBI-2876927;
CC       Q3KNW5; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-18159983, EBI-12109402;
CC       Q3KNW5; P05090: APOD; NbExp=3; IntAct=EBI-18159983, EBI-715495;
CC       Q3KNW5; Q15041: ARL6IP1; NbExp=3; IntAct=EBI-18159983, EBI-714543;
CC       Q3KNW5; Q9H2C2: ARV1; NbExp=3; IntAct=EBI-18159983, EBI-11724186;
CC       Q3KNW5; Q9HD20-3: ATP13A1; NbExp=3; IntAct=EBI-18159983, EBI-12069500;
CC       Q3KNW5; O95393: BMP10; NbExp=3; IntAct=EBI-18159983, EBI-3922513;
CC       Q3KNW5; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-18159983, EBI-8648738;
CC       Q3KNW5; Q96F05: C11orf24; NbExp=3; IntAct=EBI-18159983, EBI-2836238;
CC       Q3KNW5; Q96GQ5: C16orf58; NbExp=3; IntAct=EBI-18159983, EBI-8636004;
CC       Q3KNW5; O14523: C2CD2L; NbExp=3; IntAct=EBI-18159983, EBI-12822627;
CC       Q3KNW5; Q9P0B6: CCDC167; NbExp=3; IntAct=EBI-18159983, EBI-9083477;
CC       Q3KNW5; P13236: CCL4; NbExp=3; IntAct=EBI-18159983, EBI-2873970;
CC       Q3KNW5; O14735: CDIPT; NbExp=3; IntAct=EBI-18159983, EBI-358858;
CC       Q3KNW5; Q92903: CDS1; NbExp=3; IntAct=EBI-18159983, EBI-13295305;
CC       Q3KNW5; Q8NHS1: CLDND2; NbExp=3; IntAct=EBI-18159983, EBI-11959453;
CC       Q3KNW5; Q96DZ9-2: CMTM5; NbExp=3; IntAct=EBI-18159983, EBI-11522780;
CC       Q3KNW5; O95406: CNIH1; NbExp=3; IntAct=EBI-18159983, EBI-12172273;
CC       Q3KNW5; P29400-2: COL4A5; NbExp=3; IntAct=EBI-18159983, EBI-12211159;
CC       Q3KNW5; P21964: COMT; NbExp=3; IntAct=EBI-18159983, EBI-372265;
CC       Q3KNW5; Q5RI15: COX20; NbExp=3; IntAct=EBI-18159983, EBI-2834035;
CC       Q3KNW5; O43169: CYB5B; NbExp=3; IntAct=EBI-18159983, EBI-1058710;
CC       Q3KNW5; P00387: CYB5R3; NbExp=3; IntAct=EBI-18159983, EBI-1046040;
CC       Q3KNW5; P78329: CYP4F2; NbExp=3; IntAct=EBI-18159983, EBI-1752413;
CC       Q3KNW5; Q9BUN8: DERL1; NbExp=3; IntAct=EBI-18159983, EBI-398977;
CC       Q3KNW5; Q6ZPD8: DGAT2L6; NbExp=3; IntAct=EBI-18159983, EBI-12831978;
CC       Q3KNW5; Q9BV81: EMC6; NbExp=3; IntAct=EBI-18159983, EBI-2820492;
CC       Q3KNW5; Q9UKR5: ERG28; NbExp=3; IntAct=EBI-18159983, EBI-711490;
CC       Q3KNW5; Q7L5A8: FA2H; NbExp=3; IntAct=EBI-18159983, EBI-11337888;
CC       Q3KNW5; Q92520: FAM3C; NbExp=3; IntAct=EBI-18159983, EBI-2876774;
CC       Q3KNW5; Q96IV6: FAXDC2; NbExp=3; IntAct=EBI-18159983, EBI-12142299;
CC       Q3KNW5; Q9Y3D6: FIS1; NbExp=3; IntAct=EBI-18159983, EBI-3385283;
CC       Q3KNW5; Q14318: FKBP8; NbExp=3; IntAct=EBI-18159983, EBI-724839;
CC       Q3KNW5; Q01740: FMO1; NbExp=3; IntAct=EBI-18159983, EBI-12701460;
CC       Q3KNW5; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-18159983, EBI-714482;
CC       Q3KNW5; Q14802-3: FXYD3; NbExp=3; IntAct=EBI-18159983, EBI-12175685;
CC       Q3KNW5; Q9H0Q3: FXYD6; NbExp=3; IntAct=EBI-18159983, EBI-713304;
CC       Q3KNW5; Q8WWP7: GIMAP1; NbExp=3; IntAct=EBI-18159983, EBI-11991950;
CC       Q3KNW5; O95452: GJB6; NbExp=3; IntAct=EBI-18159983, EBI-13345609;
CC       Q3KNW5; P16278: GLB1; NbExp=3; IntAct=EBI-18159983, EBI-989638;
CC       Q3KNW5; Q9Y3E0: GOLT1B; NbExp=3; IntAct=EBI-18159983, EBI-4402607;
CC       Q3KNW5; O14653: GOSR2; NbExp=3; IntAct=EBI-18159983, EBI-4401517;
CC       Q3KNW5; Q8TDV0: GPR151; NbExp=3; IntAct=EBI-18159983, EBI-11955647;
CC       Q3KNW5; P02724: GYPA; NbExp=3; IntAct=EBI-18159983, EBI-702665;
CC       Q3KNW5; P04921: GYPC; NbExp=3; IntAct=EBI-18159983, EBI-7797098;
CC       Q3KNW5; Q9BUP3-3: HTATIP2; NbExp=3; IntAct=EBI-18159983, EBI-12937691;
CC       Q3KNW5; P24593: IGFBP5; NbExp=3; IntAct=EBI-18159983, EBI-720480;
CC       Q3KNW5; P11215: ITGAM; NbExp=3; IntAct=EBI-18159983, EBI-2568251;
CC       Q3KNW5; Q9UBY5: LPAR3; NbExp=3; IntAct=EBI-18159983, EBI-12033434;
CC       Q3KNW5; P48449: LSS; NbExp=3; IntAct=EBI-18159983, EBI-3930711;
CC       Q3KNW5; Q13021: MALL; NbExp=3; IntAct=EBI-18159983, EBI-750078;
CC       Q3KNW5; Q6N075: MFSD5; NbExp=3; IntAct=EBI-18159983, EBI-3920969;
CC       Q3KNW5; Q6ZSS7: MFSD6; NbExp=3; IntAct=EBI-18159983, EBI-2858252;
CC       Q3KNW5; A0A0C4DFN3: MGLL; NbExp=3; IntAct=EBI-18159983, EBI-12866138;
CC       Q3KNW5; P11836: MS4A1; NbExp=3; IntAct=EBI-18159983, EBI-2808234;
CC       Q3KNW5; Q9UHE5: NAT8; NbExp=3; IntAct=EBI-18159983, EBI-2863634;
CC       Q3KNW5; Q99519: NEU1; NbExp=3; IntAct=EBI-18159983, EBI-721517;
CC       Q3KNW5; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-18159983, EBI-10317425;
CC       Q3KNW5; Q8IXM6: NRM; NbExp=3; IntAct=EBI-18159983, EBI-10262547;
CC       Q3KNW5; Q8NG98: OR7D4; NbExp=3; IntAct=EBI-18159983, EBI-18164026;
CC       Q3KNW5; Q9P0S3: ORMDL1; NbExp=3; IntAct=EBI-18159983, EBI-1054848;
CC       Q3KNW5; Q99650: OSMR; NbExp=3; IntAct=EBI-18159983, EBI-2804080;
CC       Q3KNW5; Q9Y5Y5: PEX16; NbExp=3; IntAct=EBI-18159983, EBI-981985;
CC       Q3KNW5; Q86T03: PIP4P1; NbExp=3; IntAct=EBI-18159983, EBI-6164623;
CC       Q3KNW5; Q8N4L2: PIP4P2; NbExp=3; IntAct=EBI-18159983, EBI-2820617;
CC       Q3KNW5; Q9Y342: PLLP; NbExp=3; IntAct=EBI-18159983, EBI-3919291;
CC       Q3KNW5; P60201-2: PLP1; NbExp=3; IntAct=EBI-18159983, EBI-12188331;
CC       Q3KNW5; P54315: PNLIPRP1; NbExp=3; IntAct=EBI-18159983, EBI-8652812;
CC       Q3KNW5; O60831: PRAF2; NbExp=3; IntAct=EBI-18159983, EBI-2506064;
CC       Q3KNW5; Q7Z6L0: PRRT2; NbExp=3; IntAct=EBI-18159983, EBI-722696;
CC       Q3KNW5; P49768-2: PSEN1; NbExp=3; IntAct=EBI-18159983, EBI-11047108;
CC       Q3KNW5; Q9NZ42: PSENEN; NbExp=3; IntAct=EBI-18159983, EBI-998468;
CC       Q3KNW5; Q9Y225-2: RNF24; NbExp=3; IntAct=EBI-18159983, EBI-13044680;
CC       Q3KNW5; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-18159983, EBI-10244780;
CC       Q3KNW5; Q9NTJ5: SACM1L; NbExp=3; IntAct=EBI-18159983, EBI-3917235;
CC       Q3KNW5; Q969E2: SCAMP4; NbExp=3; IntAct=EBI-18159983, EBI-4403649;
CC       Q3KNW5; Q8TAC9: SCAMP5; NbExp=3; IntAct=EBI-18159983, EBI-2695784;
CC       Q3KNW5; O00767: SCD; NbExp=3; IntAct=EBI-18159983, EBI-2684237;
CC       Q3KNW5; Q9Y6X1: SERP1; NbExp=3; IntAct=EBI-18159983, EBI-10329948;
CC       Q3KNW5; Q8N6R1: SERP2; NbExp=3; IntAct=EBI-18159983, EBI-749270;
CC       Q3KNW5; O95562: SFT2D2; NbExp=3; IntAct=EBI-18159983, EBI-4402330;
CC       Q3KNW5; Q9H9B4: SFXN1; NbExp=3; IntAct=EBI-18159983, EBI-355861;
CC       Q3KNW5; Q9Y666-2: SLC12A7; NbExp=3; IntAct=EBI-18159983, EBI-12854384;
CC       Q3KNW5; Q96AG3: SLC25A46; NbExp=3; IntAct=EBI-18159983, EBI-10281975;
CC       Q3KNW5; Q9BRI3: SLC30A2; NbExp=3; IntAct=EBI-18159983, EBI-8644112;
CC       Q3KNW5; Q99726: SLC30A3; NbExp=3; IntAct=EBI-18159983, EBI-10294651;
CC       Q3KNW5; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-18159983, EBI-17295964;
CC       Q3KNW5; Q8TBE7: SLC35G2; NbExp=3; IntAct=EBI-18159983, EBI-727304;
CC       Q3KNW5; Q9H2H9: SLC38A1; NbExp=3; IntAct=EBI-18159983, EBI-9978441;
CC       Q3KNW5; Q13433-2: SLC39A6; NbExp=3; IntAct=EBI-18159983, EBI-12956703;
CC       Q3KNW5; Q9NUM3: SLC39A9; NbExp=3; IntAct=EBI-18159983, EBI-2823239;
CC       Q3KNW5; Q8IVJ1: SLC41A1; NbExp=3; IntAct=EBI-18159983, EBI-12266234;
CC       Q3KNW5; Q8N2U9: SLC66A2; NbExp=3; IntAct=EBI-18159983, EBI-3907610;
CC       Q3KNW5; P30825: SLC7A1; NbExp=3; IntAct=EBI-18159983, EBI-4289564;
CC       Q3KNW5; Q0VAQ4: SMAGP; NbExp=3; IntAct=EBI-18159983, EBI-10226799;
CC       Q3KNW5; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-18159983, EBI-12188413;
CC       Q3KNW5; Q6UX34: SNORC; NbExp=3; IntAct=EBI-18159983, EBI-11957067;
CC       Q3KNW5; P02808: STATH; NbExp=3; IntAct=EBI-18159983, EBI-738687;
CC       Q3KNW5; Q86Y82: STX12; NbExp=3; IntAct=EBI-18159983, EBI-2691717;
CC       Q3KNW5; O15400: STX7; NbExp=3; IntAct=EBI-18159983, EBI-3221827;
CC       Q3KNW5; Q9UNK0: STX8; NbExp=3; IntAct=EBI-18159983, EBI-727240;
CC       Q3KNW5; O43759-2: SYNGR1; NbExp=3; IntAct=EBI-18159983, EBI-12187159;
CC       Q3KNW5; P57105: SYNJ2BP; NbExp=3; IntAct=EBI-18159983, EBI-1049004;
CC       Q3KNW5; Q03518: TAP1; NbExp=3; IntAct=EBI-18159983, EBI-747259;
CC       Q3KNW5; Q9NZ01: TECR; NbExp=3; IntAct=EBI-18159983, EBI-2877718;
CC       Q3KNW5; P02787: TF; NbExp=3; IntAct=EBI-18159983, EBI-714319;
CC       Q3KNW5; P48230: TM4SF4; NbExp=3; IntAct=EBI-18159983, EBI-8650934;
CC       Q3KNW5; Q6UX40: TMEM107; NbExp=3; IntAct=EBI-18159983, EBI-12845616;
CC       Q3KNW5; P17152: TMEM11; NbExp=3; IntAct=EBI-18159983, EBI-723946;
CC       Q3KNW5; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-18159983, EBI-10171534;
CC       Q3KNW5; Q5BJH2-2: TMEM128; NbExp=3; IntAct=EBI-18159983, EBI-10694905;
CC       Q3KNW5; Q96AN5: TMEM143; NbExp=3; IntAct=EBI-18159983, EBI-13342951;
CC       Q3KNW5; Q9Y6G1: TMEM14A; NbExp=3; IntAct=EBI-18159983, EBI-2800360;
CC       Q3KNW5; Q9P0S9: TMEM14C; NbExp=3; IntAct=EBI-18159983, EBI-2339195;
CC       Q3KNW5; I3L0A0: TMEM189-UBE2V1; NbExp=3; IntAct=EBI-18159983, EBI-12213001;
CC       Q3KNW5; Q969S6: TMEM203; NbExp=3; IntAct=EBI-18159983, EBI-12274070;
CC       Q3KNW5; Q9BTX3: TMEM208; NbExp=3; IntAct=EBI-18159983, EBI-12876824;
CC       Q3KNW5; A2RU14: TMEM218; NbExp=3; IntAct=EBI-18159983, EBI-10173151;
CC       Q3KNW5; Q8NBD8: TMEM229B; NbExp=3; IntAct=EBI-18159983, EBI-12195227;
CC       Q3KNW5; Q8WY98: TMEM234; NbExp=3; IntAct=EBI-18159983, EBI-8642211;
CC       Q3KNW5; Q8WW34-2: TMEM239; NbExp=3; IntAct=EBI-18159983, EBI-11528917;
CC       Q3KNW5; Q9NWH2: TMEM242; NbExp=3; IntAct=EBI-18159983, EBI-10315004;
CC       Q3KNW5; Q8N6L7: TMEM252; NbExp=3; IntAct=EBI-18159983, EBI-8787626;
CC       Q3KNW5; E9PQX1: TMEM262; NbExp=3; IntAct=EBI-18159983, EBI-17180389;
CC       Q3KNW5; P56557: TMEM50B; NbExp=3; IntAct=EBI-18159983, EBI-12366453;
CC       Q3KNW5; Q9H2L4: TMEM60; NbExp=3; IntAct=EBI-18159983, EBI-2852148;
CC       Q3KNW5; Q6PI78: TMEM65; NbExp=3; IntAct=EBI-18159983, EBI-6656213;
CC       Q3KNW5; Q8N2M4: TMEM86A; NbExp=3; IntAct=EBI-18159983, EBI-12015604;
CC       Q3KNW5; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-18159983, EBI-2548832;
CC       Q3KNW5; Q6ZUI0: TPRG1; NbExp=3; IntAct=EBI-18159983, EBI-17249488;
CC       Q3KNW5; Q9NSU2-1: TREX1; NbExp=3; IntAct=EBI-18159983, EBI-16746122;
CC       Q3KNW5; A0AVG3: TSNARE1; NbExp=3; IntAct=EBI-18159983, EBI-12003468;
CC       Q3KNW5; O60636: TSPAN2; NbExp=3; IntAct=EBI-18159983, EBI-3914288;
CC       Q3KNW5; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-18159983, EBI-12195249;
CC       Q3KNW5; Q9NYZ1: TVP23B; NbExp=3; IntAct=EBI-18159983, EBI-11343401;
CC       Q3KNW5; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-18159983, EBI-988826;
CC       Q3KNW5; Q53HI1: UNC50; NbExp=3; IntAct=EBI-18159983, EBI-7601760;
CC       Q3KNW5; O75379: VAMP4; NbExp=3; IntAct=EBI-18159983, EBI-744953;
CC       Q3KNW5; Q9Y548: YIPF1; NbExp=3; IntAct=EBI-18159983, EBI-7850136;
CC       Q3KNW5; Q9BWQ6: YIPF2; NbExp=3; IntAct=EBI-18159983, EBI-751204;
CC       Q3KNW5; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-18159983, EBI-751210;
CC       Q3KNW5; Q96MV8: ZDHHC15; NbExp=3; IntAct=EBI-18159983, EBI-12837904;
CC       Q3KNW5; O95159: ZFPL1; NbExp=3; IntAct=EBI-18159983, EBI-718439;
CC       Q3KNW5; Q96FB2; NbExp=3; IntAct=EBI-18159983, EBI-2857623;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Highly expressed in testis, placenta and pancreas.
CC       Moderately expressed in heart, lung and mammary gland. Weakly expressed
CC       in brain, colon, kidney, liver, ovary, prostate, small intestine,
CC       spleen and thymus. {ECO:0000269|PubMed:17491011}.
CC   -!- PTM: Glycosylated. {ECO:0000269|PubMed:17491011}.
CC   -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC       2.A.28) family. {ECO:0000305}.
DR   EMBL; EF437223; ABO38126.1; -; mRNA.
DR   EMBL; AJ583502; CAE47477.1; -; mRNA.
DR   EMBL; CH471057; EAX05969.1; -; Genomic_DNA.
DR   EMBL; BC107051; AAI07052.1; -; mRNA.
DR   EMBL; BC107052; AAI07053.1; -; mRNA.
DR   CCDS; CCDS3614.1; -.
DR   RefSeq; NP_932069.1; NM_197965.2.
DR   IntAct; Q3KNW5; 145.
DR   STRING; 9606.ENSP00000273905; -.
DR   DrugBank; DB05804; Prasterone sulfate.
DR   DrugBank; DB02789; Pregnenolone.
DR   TCDB; 2.A.28.1.4; the bile acid:na(+) symporter (bass) family.
DR   BioMuta; SLC10A6; -.
DR   DMDM; 160358735; -.
DR   PaxDb; Q3KNW5; -.
DR   PeptideAtlas; Q3KNW5; -.
DR   PRIDE; Q3KNW5; -.
DR   ProteomicsDB; 61709; -.
DR   Antibodypedia; 14387; 40 antibodies.
DR   Ensembl; ENST00000273905; ENSP00000273905; ENSG00000145283.
DR   GeneID; 345274; -.
DR   KEGG; hsa:345274; -.
DR   UCSC; uc003hqd.2; human.
DR   CTD; 345274; -.
DR   DisGeNET; 345274; -.
DR   EuPathDB; HostDB:ENSG00000145283.7; -.
DR   GeneCards; SLC10A6; -.
DR   HGNC; HGNC:30603; SLC10A6.
DR   HPA; ENSG00000145283; Tissue enhanced (adipose tissue, breast, skin).
DR   MIM; 613366; gene.
DR   neXtProt; NX_Q3KNW5; -.
DR   OpenTargets; ENSG00000145283; -.
DR   PharmGKB; PA142670910; -.
DR   eggNOG; KOG2718; Eukaryota.
DR   eggNOG; COG0385; LUCA.
DR   GeneTree; ENSGT00950000182808; -.
DR   HOGENOM; CLU_034788_7_5_1; -.
DR   InParanoid; Q3KNW5; -.
DR   KO; K14346; -.
DR   OMA; MEIGIHN; -.
DR   OrthoDB; 1148347at2759; -.
DR   PhylomeDB; Q3KNW5; -.
DR   TreeFam; TF315811; -.
DR   Reactome; R-HSA-425366; Transport of bile salts and organic acids, metal ions and amine compounds.
DR   BioGRID-ORCS; 345274; 1 hit in 780 CRISPR screens.
DR   GenomeRNAi; 345274; -.
DR   Pharos; Q3KNW5; Tdark.
DR   PRO; PR:Q3KNW5; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q3KNW5; protein.
DR   Bgee; ENSG00000145283; Expressed in ectocervix and 69 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0008508; F:bile acid:sodium symporter activity; IBA:GO_Central.
DR   GO; GO:0043250; F:sodium-dependent organic anion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0015721; P:bile acid and bile salt transport; IBA:GO_Central.
DR   GO; GO:0043251; P:sodium-dependent organic anion transport; IEA:Ensembl.
DR   GO; GO:0055085; P:transmembrane transport; TAS:Reactome.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR   InterPro; IPR004710; Bilac:Na_transpt.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR030203; SLC10A6.
DR   PANTHER; PTHR10361; PTHR10361; 1.
DR   PANTHER; PTHR10361:SF55; PTHR10361:SF55; 1.
DR   Pfam; PF01758; SBF; 1.
DR   TIGRFAMs; TIGR00841; bass; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein; Ion transport; Membrane; Polymorphism; Reference proteome;
KW   Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..377
FT                   /note="Solute carrier family 10 member 6"
FT                   /id="PRO_0000309215"
FT   TOPO_DOM        1..29
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        30..50
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        51..67
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        89..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..159
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..195
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..216
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..226
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        248..266
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..290
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        312..377
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        4
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        157
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VARIANT         6
FT                   /note="S -> F (in dbSNP:rs17694522)"
FT                   /id="VAR_036904"
FT   VARIANT         114
FT                   /note="I -> V (in dbSNP:rs13106574)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_036905"
SQ   SEQUENCE   377 AA;  41259 MW;  A68B0F034B5BE83F CRC64;
     MRANCSSSSA CPANSSEEEL PVGLEVHGNL ELVFTVVSTV MMGLLMFSLG CSVEIRKLWS
     HIRRPWGIAV GLLCQFGLMP FTAYLLAISF SLKPVQAIAV LIMGCCPGGT ISNIFTFWVD
     GDMDLSISMT TCSTVAALGM MPLCIYLYTW SWSLQQNLTI PYQNIGITLV CLTIPVAFGV
     YVNYRWPKQS KIILKIGAVV GGVLLLVVAV AGVVLAKGSW NSDITLLTIS FIFPLIGHVT
     GFLLALFTHQ SWQRCRTISL ETGAQNIQMC ITMLQLSFTA EHLVQMLSFP LAYGLFQLID
     GFLIVAAYQT YKRRLKNKHG KKNSGCTEVC HTRKSTSSRE TNAFLEVNEE GAITPGPPGP
     MDCHRALEPV GHITSCE
//
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