ID A0A010QPK0_9PEZI Unreviewed; 1276 AA.
AC A0A010QPK0;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Patched sphingolipid transporter {ECO:0000313|EMBL:EXF82047.1};
GN ORFNames=CFIO01_00561 {ECO:0000313|EMBL:EXF82047.1};
OS Colletotrichum fioriniae PJ7.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Glomerellaceae; Colletotrichum;
OC Colletotrichum acutatum species complex.
OX NCBI_TaxID=1445577 {ECO:0000313|EMBL:EXF82047.1, ECO:0000313|Proteomes:UP000020467};
RN [1] {ECO:0000313|EMBL:EXF82047.1, ECO:0000313|Proteomes:UP000020467}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PJ7 {ECO:0000313|EMBL:EXF82047.1,
RC ECO:0000313|Proteomes:UP000020467};
RA Baroncelli R., Thon M.R.;
RT "The genome sequence of Colletotrichum fioriniae PJ7.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXF82047.1}.
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DR EMBL; JARH01000341; EXF82047.1; -; Genomic_DNA.
DR RefSeq; XP_007594232.1; XM_007594170.1.
DR AlphaFoldDB; A0A010QPK0; -.
DR STRING; 1445577.A0A010QPK0; -.
DR KEGG; cfj:CFIO01_00561; -.
DR eggNOG; KOG1933; Eukaryota.
DR HOGENOM; CLU_002359_0_1_1; -.
DR OrthoDB; 2786103at2759; -.
DR Proteomes; UP000020467; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0015918; P:sterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000020467};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1276
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5001456049"
FT TRANSMEM 267..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..611
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 739..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 828..845
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1069..1095
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1102..1125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1131..1153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1174..1203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1215..1238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 590..764
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1276 AA; 139862 MW; 7016B4D45B5D8212 CRC64;
MTLLKLLGAG GLLLASLSSS VAAEPFTPKH EAGRCAMRGH CGSKSFFGKQ LPCPDNGLAT
DPDEDLRKQI VDLCGAKWNS GPVCCDAEQV KSLASELGTP NQIVSSCPAC KDNFFNLFCT
FTCSPDQSLF LNITKTQEKN KKTMVTELDQ LISKEYGTGF FDSCKEVKFG PSNSRAIDFI
GGGAKNYSQL LKFLGDEKVI GSPFQINFPT EYTEPGMAPR DMTPKKCNDE DPNYRCACVD
CPAVCPELPA VSKPGECHIG LLPCLSFAAI FTYSVLLFAA IAAVVGHVVW RRRAKRESER
LRLLQDASPS DDEDEGDLVQ NGAMFDRPQR YYKINTWCDA AFSKLGHAAA RYQGITIGVT
LIVVVILSAG WVRFDLEKDP ARLWVSPTSP AAQEKAFFDE QFGPFYRAEK VFLVNDQHSS
GPAPVLSYDT LIWWMGVEKS VKQLKGPKFG ATLNDICLKP TGTSCVVQSV ATYFGDEPSL
VGKNDWEDQL RQCAKSPVEC RPDFGLPLEP NMILGGYDDD PAAAHAMTVT WVVQNAAEGS
PAVERAMDWE VALRDRLLEV QQEASDRGLR LSFSTEISLE QELNKSTNTD AKIVVISYII
MFLYASLALG STTLSFRDMI RNPAVALVQS KFSLGVVGIL IVLMSISASI GLFSWFGLKA
TLIIAEVIPF IVLAVGVDNI FLIVHEFERV NVSHPDEMVE ERIAKALGRM GPSILLSAMT
EVVAFALGTF VGMPAVRNFA AYAAGAVFIN AILQITLFIS VLAMNQIRVE DHRADCIPCL
QVKAARVHLS GGNGNANARF YEVPEESWLQ QFIRRTYAPA ILAKQAKAII IAVFLGLFAA
GIALIPEVQL GLDQRVAIPD GSYLIPYFND LYKYMETGPP VYFVTREFNA TARKNQREIC
ARFTTCDQFS LSNILEGERK RPDVSYISSP AASWIDDFFL WLNPDLGDSC CVENGKACFA
DRNPPWNITL SGMPQDGEFV HYLEKFLKAP TNDDCPLGGQ ASYGNAVVVD SEKDTISASH
FRTMHTPLRS QDDFINAMSA ARRIASDITK STGVEVFPYS LFYIFFDQYA SIVSLTGALL
GSAVAIIFVI ASVLLGSLMT ALVVTVTVCM TVVDIIGAMA VFGVSLNAVS LVNLIICVGI
GVEFCAHIAR AFMFPSRTVM ERAKNRFRGR DARAWTALVN VGASVFSGIT VTKLLGVFVL
AFTRSKIFEI YYFRVWLSLV VFAGTHALIF LPVALSLFGG EGYVDPESEG GIEEDLASRR
YRALVPDEET DSDDDY
//
