ID A0A010ZVK1_9ACTN Unreviewed; 2683 AA.
AC A0A010ZVK1;
DT 11-JUN-2014, integrated into UniProtKB/TrEMBL.
DT 11-JUN-2014, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE SubName: Full=Amino acid adenylation enzyme/thioester reductase family protein {ECO:0000313|EMBL:EXG82719.1};
GN ORFNames=CryarDRAFT_3919 {ECO:0000313|EMBL:EXG82719.1};
OS Cryptosporangium arvum DSM 44712.
OC Bacteria; Actinomycetota; Actinomycetes; Cryptosporangiales;
OC Cryptosporangiaceae; Cryptosporangium.
OX NCBI_TaxID=927661 {ECO:0000313|EMBL:EXG82719.1, ECO:0000313|Proteomes:UP000021053};
RN [1] {ECO:0000313|EMBL:EXG82719.1, ECO:0000313|Proteomes:UP000021053}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44712 {ECO:0000313|EMBL:EXG82719.1,
RC ECO:0000313|Proteomes:UP000021053};
RG DOE Joint Genome Institute;
RA Eisen J., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K.,
RA Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A.,
RA Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.;
RL Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EXG82719.1}.
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DR EMBL; JFBT01000001; EXG82719.1; -; Genomic_DNA.
DR PATRIC; fig|927661.3.peg.3888; -.
DR HOGENOM; CLU_227422_0_0_11; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000021053; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd19531; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 3.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 3.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 3.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 6.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000021053}.
FT DOMAIN 1015..1090
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2055..2130
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2584..2659
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2683 AA; 286696 MW; 2C41E625421AE293 CRC64;
MASPVADRVF TLDPRRRSAL AALLGARTGP GAIPRQPRDG RTFPCTPAQV RLWLADQLDT
GAVAVPNATA GLRLHGPLRV EALRSALAEV AGRHESMRTR YGVSAGVPHQ IVAATAPAPF
DVVDLTGSPA DARSAAASAV TAEAAAERFD LATGPLFRLT LCRLSDQDHV LLFAGHHIAF
DEQSVDIVLR ELAAGYAAPA GGDPGGELDY VDYACWVAGQ EVPAAADEYW RERLAPPLPD
LDLPFLTPAR RRSAAAVPGP AEPGAAAGTE SVRVRLAAGR LDRLRAVTGN QTPFVTLLAV
LDVLLARYTG SADVTVGTVS AGRARTELEP LVGCFLNPLV LRTDLAGAAT FTEVVHRVRA
TVAEAFAREV PFDLLAGRTP RRPGIHPLFQ AALHVHRHRA DEGAWPGLTT EVWHHEVGAD
ALDLTVEATP LPDGTTDLTF RTPRGAAEPG AIDRFAEAFR TLVDAVGEAP DAPLADAGRA
PRADREVLRR WNTTSRPVPS STVAALIAER VTRTPDAVAV VGAGLTWTYA DLGREVSALA
ARLTAAGCRR GTLVAVCLER SPWLVVATLA VWRAGGAYVP IDPEYPPDRQ ALVLSDSHAA
LVVTRRAQDT HLPPTPAPII HVDEPRPAPV VEVPDGPEPD DLAYVLYTSG STGRPKGVAV
EHRALGNLIA DFGHRLAAGP ADRWLAVTSL AFDIAALELY LPLVTGARLV VADEASARDG
RALGDLIRRE GVTHVQTTPS RWRLLLAGGF GRTDPSTVDR AASVGPGSAR AVTALVGGEA
LPPGLARDLR ARTGRLLNVY GPTETTVWSC AWEVPADVDE VVIGTPLANT RIQLRDPDGH
LVPVGAPGEL WIGGLGVARG YLDRPGLTAD RFRPDPDGPP GARLYRTGDL ARWRGDGQLV
FLGRTDDQVK LNGHRVELGE IENRLGGVEG VAAAAVAVTG DVAGERALVA YVVPVPGASW
DPGLVRAALA RALPDAMVPR RYVALEQLPL TPNGKLDRAA LPAPDLTPET AGYRPPGTPS
EHVVAAVFAE VLGHDRVGAD DDFLALGGHS LLAMTIAALL SEHFGREVGV ASVFTWPVVA
DLARELDRTH ADRTRATMAR RPIEPRPTGS GPAPLSLGQQ PLWFLHQLDP ADASYNMPLV
YRCAGPIDPD ALDRALTRVV ARHEALRTRF GLVDGEPALL VDPPADVTAE RVDLSAAPDP
VLAAHERVAG WTNAPFDLER DRPIRAGLIR LGPDDHVWCL VVHHIGGDGQ SLALLVEEIR
HAYDGAPRPD FPVRYSDFAA WERAVVRDGE DDAFAYWRDR LAGVPVLDLP TDRPRPPLPS
TRGAFVRHRL PIELTEAVER LAVARRSTLF VVLLAAYQAV LSRLSGQTDF CVGTSASARV
RPEIVPLIGM FTDTLALRAD LSGDPTFADL LSRTRHTVLG AFGHPRIPFE RLAAAWHLPR
DASFHPFFQT MLIVHTEDAA GVDVVPGVRA EPFDDGVTQA KFDLMAECWR DPDGLDVALN
YRTDLFDAAT MTGLAERLEA LLRAAVAAPD RPLSGVELVS SAERSRLLAL GRGASADDDP
ADVVALVAER VRLDPDAVAI VDGDEQLTYA QLAGRARALA ARLRALGVGP EVPVAVALPR
SAELIVALLG VLEAGGAYVP IDVGYPPARI EFLLRDSGAT VLVTDSPHDH FPPVDHLVLP
GDVLPGDVHP GRAEPTSAGP GAPAYVIYTS GSTGTPKGVV VSRGALAARV EWMRRRYALG
PADQVVQFAS VSFDTHVEEV WPALTAGARL VLLPPGQDLP ELLDHTPVTV LDLPTPYFHE
LVPTLDRLHL PDSLRLLILG ADQVRSDALA TWRHRVGDRV EVLNTYGPTE ATVIATAATL
GGHDTDGRPP IGRPIDRTRL YVLDEHLTPA GSGELWIAGA GLARGYLGRP GLTADRFRPD
PFGPAGTRMY RTGDRVRWRA DGQLEFLGRL DDQVKIRGYR VELGEVETAL AAQPGVRQAV
VVPRTDAAGH RTLAGYLVGD ADPADVRAGL AARLPAYLVP THLTAVDEIP LTGNGKVDRR
ALPAPDPRQD TGYLAPRTPT EELVAQVWAA VLGLDAVGMH DDFFALGGHS LLATGAVARL
CTVVDCDLTV RTLFGAPTVA GLAAAIDRLR TRPGTADRPV VARPAGAGPA PLSLGQERLW
FLHQLDPDDA SYSIHLAYRL RGPVDPARLE HALGVVVDRH DVLRTRFPEI DGEPVQDVGP
ATGVTLLRAG AAGPEEARTR VAEWVNTPFD LETGPPIRAG LVRISDDDHV LAVVLHHIAG
DGRSAGLLAA ELRRAYDGAE LPALPVQYAD FATWQRARTA GEELGYWTEQ LAGVPPLELP
TDRPRPPVPS SAGDFLVHDL PEPVVRAVRR LAAESSATPF VVLLAAYQVL LGRLTGSPDL
CVGTPIEHRP RVEVADLIGF FVNTLALRAD LSGAPSFREL VARTRDTAFA AYARQDVPFD
RILGALDLPR DVGRTPLLET MFTLHTEDAA GTDVLPGVDA EFFDAEFRQV KYDLSLDAWR
MPDGLRLVFG YRTDLFSRDT VGGWAEQFAA LLGTLLSDPD GLVSGAERTR RAVRVPRGPV
PYVAPRTAAE ELVADVWAEL LGLDRVGLYA DFFASGGHSL LAMKMLARLR AATGTRIPLR
AVFAHPVLER FAAAVEEALL ADLADLSDDE AAALLAAEEE PTP
//
